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Protein

Sodium-dependent phosphate transporter 1

Gene

Slc20a1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers susceptibility to feline leukemia virus subgroup B (FeLV-B).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Phosphate transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 1
Alternative name(s):
Feline leukemia virus subtype-B receptor
Phosphate transporter 1
Short name:
PiT-1
Solute carrier family 20 member 1
Gene namesi
Name:Slc20a1
Synonyms:Pit1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome A3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 65ExtracellularSequence analysisAdd BLAST20
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 105CytoplasmicSequence analysisAdd BLAST19
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 161ExtracellularSequence analysisAdd BLAST35
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 206CytoplasmicSequence analysisAdd BLAST24
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 233ExtracellularSequence analysis6
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 514CytoplasmicSequence analysisAdd BLAST260
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 561ExtracellularSequence analysisAdd BLAST26
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Topological domaini583 – 603CytoplasmicSequence analysisAdd BLAST21
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 653ExtracellularSequence analysisAdd BLAST29
Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Topological domaini675 – 681CytoplasmicSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000807701 – 681Sodium-dependent phosphate transporter 1Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineBy similarity1
Modified residuei273PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000007501.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni554 – 562ABy similarity9

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOVERGENiHBG053358.
InParanoidiO97596.
KOiK14640.
OMAiWINLATW.
OrthoDBiEOG091G07J5.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 2 hits.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTGATLTT STIAATAASG PLMDYLWMLI LGFIIAFVLA FSVGANDVAN
60 70 80 90 100
SFGTAVGSGV VTLKQACILA SIFETVGSVL LGAKVSETIR KGLIDVEMYN
110 120 130 140 150
TTQQLLMAGS VSAMFGSAVW QLVASFLKLP ISGTHCIVGA TIGFSLVAKG
160 170 180 190 200
QEGVKWSELI KIVMSWFISP LLSGIMSGIL FFLVRAFILR KTDPVPNGLR
210 220 230 240 250
ALPVFYACTV GINLFSIMYT GAPLLGFDKL PLWGTILISV GCAVFCALIV
260 270 280 290 300
WFFVCPRMKR KIEREIKSSP SESPLMEKKN SLKEDHEETK LSVSDIETRS
310 320 330 340 350
PVSEVGSATV PLRAVVEERT VSFKLGDLEE APERERLPSV DLKEETSIDS
360 370 380 390 400
AMNGAVQLPN GNLVQFNQAV SNQMNSSGHY QYHTVHKDSG LYKELLHKLH
410 420 430 440 450
LAKVGDCMGD SGDKPLRRNN SYTSYTMAIC GMPLDSFRAK EGEQKGEEME
460 470 480 490 500
KLTWPNAESK KRIRMDSYTS YCNAVSDIHS ASEMDMSVKA EMGLGDRKGS
510 520 530 540 550
SSSLEEWYDQ DKPEVSLLFQ FLQILTACFG SFAHGGNDVS NAIGPLVALY
560 570 580 590 600
LVYDTGDVSS KVATPIWLLL YGGVGICIGL WVWGRRVIQT MGKDLTPITP
610 620 630 640 650
SSGFSIELAS ALTVVIASNI GLPISTTHCK VGSVVSVGWL RSKKAVDWRL
660 670 680
FRNIFMAWFV TVPISGVISA AIMAVFKYVI L
Length:681
Mass (Da):74,020
Last modified:December 20, 2005 - v2
Checksum:i243238766D6A984B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127L → F in AAS00090 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074085 mRNA. Translation: AAD08995.1.
AY514486 mRNA. Translation: AAS00090.1.
RefSeqiNP_001009840.1. NM_001009840.1.
XP_011279434.1. XM_011281132.1.

Genome annotation databases

EnsembliENSFCAT00000008095; ENSFCAP00000007501; ENSFCAG00000008093.
GeneIDi493789.
KEGGifca:493789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074085 mRNA. Translation: AAD08995.1.
AY514486 mRNA. Translation: AAS00090.1.
RefSeqiNP_001009840.1. NM_001009840.1.
XP_011279434.1. XM_011281132.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000007501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000008095; ENSFCAP00000007501; ENSFCAG00000008093.
GeneIDi493789.
KEGGifca:493789.

Organism-specific databases

CTDi6574.

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOVERGENiHBG053358.
InParanoidiO97596.
KOiK14640.
OMAiWINLATW.
OrthoDBiEOG091G07J5.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 2 hits.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS20A1_FELCA
AccessioniPrimary (citable) accession number: O97596
Secondary accession number(s): Q6R4N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ectopic expression of feline SLC20A1 in guinea pig cells which are not permissive to Feline leukemia virus subgroup B (FeLV-B) confers susceptibility to FeLV-B infection.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.