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O97596 (S20A1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sodium-dependent phosphate transporter 1
Alternative name(s):
Feline leukemia virus subtype-B receptor
Phosphate transporter 1
Short name=PiT-1
Solute carrier family 20 member 1
Gene names
Name:Slc20a1
Synonyms:Pit1
OrganismFelis catus (Cat) (Felis silvestris catus) [Complete proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers susceptibility to feline leukemia virus subgroup B (FeLV-B).

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Ectopic expression of feline SLC20A1 in guinea pig cells which are not permissive to Feline leukemia virus subgroup B (FeLV-B) confers susceptibility to FeLV-B infection.

Sequence similarities

Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681Sodium-dependent phosphate transporter 1
PRO_0000080770

Regions

Topological domain1 – 2424Cytoplasmic Potential
Transmembrane25 – 4521Helical; Potential
Topological domain46 – 6520Extracellular Potential
Transmembrane66 – 8621Helical; Potential
Topological domain87 – 10519Cytoplasmic Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 16135Extracellular Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 20624Cytoplasmic Potential
Transmembrane207 – 22721Helical; Potential
Topological domain228 – 2336Extracellular Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 514260Cytoplasmic Potential
Transmembrane515 – 53521Helical; Potential
Topological domain536 – 56126Extracellular Potential
Transmembrane562 – 58221Helical; Potential
Topological domain583 – 60321Cytoplasmic Potential
Transmembrane604 – 62421Helical; Potential
Topological domain625 – 65329Extracellular Potential
Transmembrane654 – 67421Helical; Potential
Topological domain675 – 6817Cytoplasmic Potential
Region554 – 5629A By similarity

Amino acid modifications

Modified residue2681Phosphoserine By similarity
Modified residue2691Phosphoserine By similarity
Modified residue2731Phosphoserine By similarity

Experimental info

Sequence conflict1271L → F in AAS00090. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O97596 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 243238766D6A984B

FASTA68174,020
        10         20         30         40         50         60 
MAFTGATLTT STIAATAASG PLMDYLWMLI LGFIIAFVLA FSVGANDVAN SFGTAVGSGV 

        70         80         90        100        110        120 
VTLKQACILA SIFETVGSVL LGAKVSETIR KGLIDVEMYN TTQQLLMAGS VSAMFGSAVW 

       130        140        150        160        170        180 
QLVASFLKLP ISGTHCIVGA TIGFSLVAKG QEGVKWSELI KIVMSWFISP LLSGIMSGIL 

       190        200        210        220        230        240 
FFLVRAFILR KTDPVPNGLR ALPVFYACTV GINLFSIMYT GAPLLGFDKL PLWGTILISV 

       250        260        270        280        290        300 
GCAVFCALIV WFFVCPRMKR KIEREIKSSP SESPLMEKKN SLKEDHEETK LSVSDIETRS 

       310        320        330        340        350        360 
PVSEVGSATV PLRAVVEERT VSFKLGDLEE APERERLPSV DLKEETSIDS AMNGAVQLPN 

       370        380        390        400        410        420 
GNLVQFNQAV SNQMNSSGHY QYHTVHKDSG LYKELLHKLH LAKVGDCMGD SGDKPLRRNN 

       430        440        450        460        470        480 
SYTSYTMAIC GMPLDSFRAK EGEQKGEEME KLTWPNAESK KRIRMDSYTS YCNAVSDIHS 

       490        500        510        520        530        540 
ASEMDMSVKA EMGLGDRKGS SSSLEEWYDQ DKPEVSLLFQ FLQILTACFG SFAHGGNDVS 

       550        560        570        580        590        600 
NAIGPLVALY LVYDTGDVSS KVATPIWLLL YGGVGICIGL WVWGRRVIQT MGKDLTPITP 

       610        620        630        640        650        660 
SSGFSIELAS ALTVVIASNI GLPISTTHCK VGSVVSVGWL RSKKAVDWRL FRNIFMAWFV 

       670        680 
TVPISGVISA AIMAVFKYVI L

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References

[1]"Retrovirus receptor PiT-1 of the Felis catus."
Rudra-Ganguly N., Ghosh A.K., Roy-Burman P.
Biochim. Biophys. Acta 1443:407-413(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphoma.
[2]"Feline homolog of gibbon ape leukemia virus receptor (GALV1) is a receptor for feline leukemia virus (subtype-B)."
Lochrie M.A.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Occipital cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF074085 mRNA. Translation: AAD08995.1.
AY514486 mRNA. Translation: AAS00090.1.
RefSeqNP_001009840.1. NM_001009840.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000008095; ENSFCAP00000007501; ENSFCAG00000008093.
GeneID493789.
KEGGfca:493789.

Organism-specific databases

CTD6574.

Phylogenomic databases

GeneTreeENSGT00390000014879.
HOVERGENHBG053358.
KOK14640.

Family and domain databases

InterProIPR001204. Phos_transporter.
[Graphical view]
PANTHERPTHR11101. PTHR11101. 1 hit.
PfamPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameS20A1_FELCA
AccessionPrimary (citable) accession number: O97596
Secondary accession number(s): Q6R4N7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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