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O97596

- S20A1_FELCA

UniProt

O97596 - S20A1_FELCA

Protein

Sodium-dependent phosphate transporter 1

Gene

Slc20a1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers susceptibility to feline leukemia virus subgroup B (FeLV-B).

    GO - Molecular functioni

    1. inorganic phosphate transmembrane transporter activity Source: InterPro
    2. signal transducer activity Source: Ensembl
    3. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. phosphate ion transport Source: UniProtKB-KW
    2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Phosphate transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transporter 1
    Alternative name(s):
    Feline leukemia virus subtype-B receptor
    Phosphate transporter 1
    Short name:
    PiT-1
    Solute carrier family 20 member 1
    Gene namesi
    Name:Slc20a1
    Synonyms:Pit1
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome A3

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 681681Sodium-dependent phosphate transporter 1PRO_0000080770Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691PhosphoserineBy similarity
    Modified residuei273 – 2731PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 6520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini87 – 10519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini127 – 16135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini228 – 2336ExtracellularSequence Analysis
    Topological domaini255 – 514260CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini536 – 56126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini583 – 60321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini625 – 65329ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini675 – 6817CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei515 – 53521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei562 – 58221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei604 – 62421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei654 – 67421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni554 – 5629ABy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00390000014879.
    HOVERGENiHBG053358.
    KOiK14640.
    OMAiSSLEEWC.

    Family and domain databases

    InterProiIPR001204. Phos_transporter.
    [Graphical view]
    PANTHERiPTHR11101. PTHR11101. 1 hit.
    PfamiPF01384. PHO4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O97596-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFTGATLTT STIAATAASG PLMDYLWMLI LGFIIAFVLA FSVGANDVAN    50
    SFGTAVGSGV VTLKQACILA SIFETVGSVL LGAKVSETIR KGLIDVEMYN 100
    TTQQLLMAGS VSAMFGSAVW QLVASFLKLP ISGTHCIVGA TIGFSLVAKG 150
    QEGVKWSELI KIVMSWFISP LLSGIMSGIL FFLVRAFILR KTDPVPNGLR 200
    ALPVFYACTV GINLFSIMYT GAPLLGFDKL PLWGTILISV GCAVFCALIV 250
    WFFVCPRMKR KIEREIKSSP SESPLMEKKN SLKEDHEETK LSVSDIETRS 300
    PVSEVGSATV PLRAVVEERT VSFKLGDLEE APERERLPSV DLKEETSIDS 350
    AMNGAVQLPN GNLVQFNQAV SNQMNSSGHY QYHTVHKDSG LYKELLHKLH 400
    LAKVGDCMGD SGDKPLRRNN SYTSYTMAIC GMPLDSFRAK EGEQKGEEME 450
    KLTWPNAESK KRIRMDSYTS YCNAVSDIHS ASEMDMSVKA EMGLGDRKGS 500
    SSSLEEWYDQ DKPEVSLLFQ FLQILTACFG SFAHGGNDVS NAIGPLVALY 550
    LVYDTGDVSS KVATPIWLLL YGGVGICIGL WVWGRRVIQT MGKDLTPITP 600
    SSGFSIELAS ALTVVIASNI GLPISTTHCK VGSVVSVGWL RSKKAVDWRL 650
    FRNIFMAWFV TVPISGVISA AIMAVFKYVI L 681
    Length:681
    Mass (Da):74,020
    Last modified:December 20, 2005 - v2
    Checksum:i243238766D6A984B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1271L → F in AAS00090. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074085 mRNA. Translation: AAD08995.1.
    AY514486 mRNA. Translation: AAS00090.1.
    RefSeqiNP_001009840.1. NM_001009840.1.

    Genome annotation databases

    EnsembliENSFCAT00000008095; ENSFCAP00000007501; ENSFCAG00000008093.
    GeneIDi493789.
    KEGGifca:493789.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074085 mRNA. Translation: AAD08995.1 .
    AY514486 mRNA. Translation: AAS00090.1 .
    RefSeqi NP_001009840.1. NM_001009840.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000008095 ; ENSFCAP00000007501 ; ENSFCAG00000008093 .
    GeneIDi 493789.
    KEGGi fca:493789.

    Organism-specific databases

    CTDi 6574.

    Phylogenomic databases

    GeneTreei ENSGT00390000014879.
    HOVERGENi HBG053358.
    KOi K14640.
    OMAi SSLEEWC.

    Family and domain databases

    InterProi IPR001204. Phos_transporter.
    [Graphical view ]
    PANTHERi PTHR11101. PTHR11101. 1 hit.
    Pfami PF01384. PHO4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lymphoma.
    2. "Feline homolog of gibbon ape leukemia virus receptor (GALV1) is a receptor for feline leukemia virus (subtype-B)."
      Lochrie M.A.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Occipital cortex.

    Entry informationi

    Entry nameiS20A1_FELCA
    AccessioniPrimary (citable) accession number: O97596
    Secondary accession number(s): Q6R4N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Ectopic expression of feline SLC20A1 in guinea pig cells which are not permissive to Feline leukemia virus subgroup B (FeLV-B) confers susceptibility to FeLV-B infection.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3