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Protein

Sodium-dependent phosphate transporter 1

Gene

Slc20a1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers susceptibility to feline leukemia virus subgroup B (FeLV-B).

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. signal transducer activity Source: Ensembl
  3. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphate ion transport Source: UniProtKB-KW
  2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Phosphate transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 1
Alternative name(s):
Feline leukemia virus subtype-B receptor
Phosphate transporter 1
Short name:
PiT-1
Solute carrier family 20 member 1
Gene namesi
Name:Slc20a1
Synonyms:Pit1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712 Componenti: Chromosome A3

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Topological domaini46 – 6520ExtracellularSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Topological domaini87 – 10519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 16135ExtracellularSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 20624CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Topological domaini228 – 2336ExtracellularSequence Analysis
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 514260CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence AnalysisAdd
BLAST
Topological domaini536 – 56126ExtracellularSequence AnalysisAdd
BLAST
Transmembranei562 – 58221HelicalSequence AnalysisAdd
BLAST
Topological domaini583 – 60321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei604 – 62421HelicalSequence AnalysisAdd
BLAST
Topological domaini625 – 65329ExtracellularSequence AnalysisAdd
BLAST
Transmembranei654 – 67421HelicalSequence AnalysisAdd
BLAST
Topological domaini675 – 6817CytoplasmicSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681Sodium-dependent phosphate transporter 1PRO_0000080770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691PhosphoserineBy similarity
Modified residuei273 – 2731PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni554 – 5629ABy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000014879.
HOVERGENiHBG053358.
InParanoidiO97596.
KOiK14640.
OMAiWINLATW.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTGATLTT STIAATAASG PLMDYLWMLI LGFIIAFVLA FSVGANDVAN
60 70 80 90 100
SFGTAVGSGV VTLKQACILA SIFETVGSVL LGAKVSETIR KGLIDVEMYN
110 120 130 140 150
TTQQLLMAGS VSAMFGSAVW QLVASFLKLP ISGTHCIVGA TIGFSLVAKG
160 170 180 190 200
QEGVKWSELI KIVMSWFISP LLSGIMSGIL FFLVRAFILR KTDPVPNGLR
210 220 230 240 250
ALPVFYACTV GINLFSIMYT GAPLLGFDKL PLWGTILISV GCAVFCALIV
260 270 280 290 300
WFFVCPRMKR KIEREIKSSP SESPLMEKKN SLKEDHEETK LSVSDIETRS
310 320 330 340 350
PVSEVGSATV PLRAVVEERT VSFKLGDLEE APERERLPSV DLKEETSIDS
360 370 380 390 400
AMNGAVQLPN GNLVQFNQAV SNQMNSSGHY QYHTVHKDSG LYKELLHKLH
410 420 430 440 450
LAKVGDCMGD SGDKPLRRNN SYTSYTMAIC GMPLDSFRAK EGEQKGEEME
460 470 480 490 500
KLTWPNAESK KRIRMDSYTS YCNAVSDIHS ASEMDMSVKA EMGLGDRKGS
510 520 530 540 550
SSSLEEWYDQ DKPEVSLLFQ FLQILTACFG SFAHGGNDVS NAIGPLVALY
560 570 580 590 600
LVYDTGDVSS KVATPIWLLL YGGVGICIGL WVWGRRVIQT MGKDLTPITP
610 620 630 640 650
SSGFSIELAS ALTVVIASNI GLPISTTHCK VGSVVSVGWL RSKKAVDWRL
660 670 680
FRNIFMAWFV TVPISGVISA AIMAVFKYVI L
Length:681
Mass (Da):74,020
Last modified:December 20, 2005 - v2
Checksum:i243238766D6A984B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271L → F in AAS00090 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074085 mRNA. Translation: AAD08995.1.
AY514486 mRNA. Translation: AAS00090.1.
RefSeqiNP_001009840.1. NM_001009840.1.

Genome annotation databases

EnsembliENSFCAT00000008095; ENSFCAP00000007501; ENSFCAG00000008093.
GeneIDi493789.
KEGGifca:493789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074085 mRNA. Translation: AAD08995.1.
AY514486 mRNA. Translation: AAS00090.1.
RefSeqiNP_001009840.1. NM_001009840.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000008095; ENSFCAP00000007501; ENSFCAG00000008093.
GeneIDi493789.
KEGGifca:493789.

Organism-specific databases

CTDi6574.

Phylogenomic databases

GeneTreeiENSGT00390000014879.
HOVERGENiHBG053358.
InParanoidiO97596.
KOiK14640.
OMAiWINLATW.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoma.
  2. "Feline homolog of gibbon ape leukemia virus receptor (GALV1) is a receptor for feline leukemia virus (subtype-B)."
    Lochrie M.A.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Occipital cortex.

Entry informationi

Entry nameiS20A1_FELCA
AccessioniPrimary (citable) accession number: O97596
Secondary accession number(s): Q6R4N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 4, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ectopic expression of feline SLC20A1 in guinea pig cells which are not permissive to Feline leukemia virus subgroup B (FeLV-B) confers susceptibility to FeLV-B infection.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.