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O97592 (DMD_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dystrophin
Gene names
Name:DMD
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length3680 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission By similarity.

Subunit structure

Interacts with SYNM. Interacts with the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells By similarity.

Subcellular location

Cell membranesarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Note: In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 By similarity.

Sequence similarities

Contains 1 actin-binding domain.

Contains 2 CH (calponin-homology) domains.

Contains 24 spectrin repeats.

Contains 1 WW domain.

Contains 1 ZZ-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 36803680Dystrophin
PRO_0000076074

Regions

Domain1 – 237237Actin-binding
Domain15 – 119105CH 1
Domain134 – 237104CH 2
Repeat340 – 448109Spectrin 1
Repeat449 – 557109Spectrin 2
Repeat560 – 668109Spectrin 3
Repeat720 – 829110Spectrin 4
Repeat831 – 935105Spectrin 5
Repeat944 – 1047104Spectrin 6
Repeat1050 – 1156107Spectrin 7
Repeat1159 – 1265107Spectrin 8
Repeat1268 – 1369102Spectrin 9
Repeat1370 – 146596Spectrin 10
Repeat1470 – 1570101Spectrin 11
Repeat1573 – 1678106Spectrin 12
Repeat1681 – 1780100Spectrin 13
Repeat1781 – 187696Spectrin 14
Repeat1879 – 1981103Spectrin 15
Repeat1994 – 2103110Spectrin 16
Repeat2106 – 2210105Spectrin 17
Repeat2213 – 2320108Spectrin 18
Repeat2321 – 241898Spectrin 19
Repeat2470 – 2572103Spectrin 20
Repeat2575 – 2681107Spectrin 21
Repeat2684 – 2797114Spectrin 22
Repeat2803 – 2925123Spectrin 23
Repeat2930 – 3035106Spectrin 24
Domain3050 – 308334WW
Zinc finger3302 – 334948ZZ-type
Region63 – 7210ANK2- and ANK-3 binding By similarity
Region1418 – 1915498Interaction with SYNM By similarity
Region3053 – 3403351Interaction with SYNM By similarity
Region3461 – 351353Binds to SNTB1 By similarity

Amino acid modifications

Modified residue34781Phosphoserine By similarity
Modified residue36071Phosphoserine By similarity
Modified residue36081Phosphoserine By similarity
Modified residue36121Phosphoserine By similarity
Modified residue36181Phosphoserine By similarity
Modified residue36191Phosphoserine By similarity
Modified residue36611Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O97592 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 539F1C9D72377872

FASTA3,680425,653
        10         20         30         40         50         60 
MLWWEEVEDC YEREDVQKKT FTKWVNAQFS KFGKQHIENL FSDLQDGRRL LDLLEGLTGQ 

        70         80         90        100        110        120 
KLPKEKGSTR VHALNNVNKA LRVLQKNNVD LVNIGSTDIV DGNHKLTLGL IWNIILHWQV 

       130        140        150        160        170        180 
KNVMKNIMAG LQQTNSEKIL LSWVRQSTRN YPQVNVINFT TSWSDGLALN ALIHSHRPDL 

       190        200        210        220        230        240 
FDWNSVVCQQ SATQRLEHAF NIAKYQLGIE KLLDPEDVAT TYPDKKSILM YITSLFQVLP 

       250        260        270        280        290        300 
QQVSIEAIQE VEMLPRPSQV TREEHFQIHH QMHYSQQITV SLAQGYERAP SFPKPRFKSY 

       310        320        330        340        350        360 
AYTQAAYVTT SDPTRSPLPS QHLETPEDKS FGRSLTETEA NLDSYQTALE EVLSWLLSAE 

       370        380        390        400        410        420 
DALQAQGEIS NDVEEVKEQF HTHEGYMMDL TSHQGRVGNV LQLGSQLIGT GKLSEDEETE 

       430        440        450        460        470        480 
VQEQMNLLNS RWECLRVASM EKQSNLHKVL MDLQNQQLKE LNDWLTKTEE RTRKMEKEPL 

       490        500        510        520        530        540 
GPDIEDLKRQ VQQHKVLQED LEQEQVRVNS LTHMVVVVDE SSGDHATAAL EEQLKVLGDR 

       550        560        570        580        590        600 
WANICRWTED RWVLLQDILL KWQRFTEEQC LFSAWLSEKE DAVNKIHTTG FKDQSEVLSN 

       610        620        630        640        650        660 
LQKLAVLKTD LEKKKQTMDK LCSLNQDLLS ALKNTVVAHK MEAWLDNFAQ RWDNLVQKLE 

       670        680        690        700        710        720 
KSSAQISQAV TTTQPSLTQT TVMETVTMVT TREHILVKHA QEELPPPPPQ KKRQIIVDSE 

       730        740        750        760        770        780 
IRKRLDVDIT ELHSWITRSE AVLQSPEFAI YRKEGNFSDL KEKVNAIERE KAEKFRKLQD 

       790        800        810        820        830        840 
ASRSAQALVE QMVNEGVNAD SIKQASEQLN SRWIEFCQLL SERLNWLEYQ NNIITFYNQL 

       850        860        870        880        890        900 
QQLEQMTTTA ENWLKTQPTT TSEPTAIKSQ LKICKDEINR LSALQPQIER LKIQSIALKE 

       910        920        930        940        950        960 
KGQGPMFLDA DFVAFTNHFN QVFADVQARE KELQTIFDSL PPMRYQETMS TILTWIQQSE 

       970        980        990       1000       1010       1020 
TKLSIPQVTV TEYDIMEQRL GELQALQSSL QEQQNGLNYL STTVKEMSKK APLSDISRKY 

      1030       1040       1050       1060       1070       1080 
QSEFEEIEGR WKKLSSQLVE HCQKLEEQMA KLRKIQNHIK TLKKWITEVD VFLKEEWPAL 

      1090       1100       1110       1120       1130       1140 
GDSEILKRQL KQCRLLVNDI QTIQPSLNSV NEGAQKMKNE AEPEFAGRLE TELRELNTQW 

      1150       1160       1170       1180       1190       1200 
DYMCRQVYAR KEALKGGLDK TVSLQKDLSE MHEWMTQAEE EYLERDFEYK TPDELQTAVE 

      1210       1220       1230       1240       1250       1260 
EMKRAKEEAQ QKEAKVKLLT ESVNSVIAQA PPAAQEALKK ELDTLTTNYQ WLCTRLNGKC 

      1270       1280       1290       1300       1310       1320 
KTLEEVWACW HELLSYLEKA NKWLSEVEVK LKTTENISGG AEEIAEVLDS LENLMQHSED 

      1330       1340       1350       1360       1370       1380 
NPNQIRILAQ TLTDGGVMDE LINEELETFN SRWRELHEEA VRRQKLLEQS IQSAQEIEKS 

      1390       1400       1410       1420       1430       1440 
LHLIQESLSS IDKQLAAYIA DKVDAAQMPQ EAQKIQSDLT SHEISLEEMK KHNQGKETAQ 

      1450       1460       1470       1480       1490       1500 
RVLSQIDVAQ KKLQDVSMKF RLFQKPANFE QRLQESKMIL DEVKMHLPAL ETKSVEQEVV 

      1510       1520       1530       1540       1550       1560 
QSQLNHCVNL YKSLSEVKSE VEMVIKTGRQ IVQKKQTENP KELDERVTAL KLHYNELGAK 

      1570       1580       1590       1600       1610       1620 
VTERKQQLEK CLKLSRKMRK EMNALTEWLA ATDMELTKRS AVEGMPSNLD SEVAWGKATQ 

      1630       1640       1650       1660       1670       1680 
KEIEKQKVHL KSVTEVGEAL KTVLGKKEML VEDKLSLLNS NWIAVTSRAE EWLNLLLEYQ 

      1690       1700       1710       1720       1730       1740 
KHMETFDQNV DYITNWIIQA DALLDESEKK KPQQKEDILK RLKAEMNDIR PKVDSTRDQA 

      1750       1760       1770       1780       1790       1800 
ANLMANRGDH CRKVVEPKIS ELNHRFAAIS HRIKTGKASI PLKELEQFNS DIQKLLEPLE 

      1810       1820       1830       1840       1850       1860 
AEIQQGVNLK EEDFNKDMSE DNEGTVKELL QRGDNLQQRI TDERKREEIK IKQQLLQTKH 

      1870       1880       1890       1900       1910       1920 
NALKDLRSQR RKKALEISHQ WYQYKRQADD LLKCLDDIEK KLASLPEPRD ERKIKEIDRE 

      1930       1940       1950       1960       1970       1980 
LQKKKEELNA VRRQAEGLSE DGAAMAVEPT QIQLSKRWRE IESKFAQFRR LNFAQIHTVH 

      1990       2000       2010       2020       2030       2040 
EESVVAMTED MPLEISYVPS TYLTEITHVS QALSEVEELL NAPDLCAQDF EDLFKQEESL 

      2050       2060       2070       2080       2090       2100 
KNIKDSLQQI SGRIDIIHNK KTAALHSATP AERAKLQEAL SRLDFQWERV NNMYKDRQGR 

      2110       2120       2130       2140       2150       2160 
FDRSVEKWRR FHYDMKILNQ WLTEAEQFLK KTQIPENWEH AKYKWYLKEL QDGIGQRQSV 

      2170       2180       2190       2200       2210       2220 
VRVLNATGEE IIQQSSKTDA SILQEKLGSL NLRWQEVCKQ LAERKKRLEE QKNILSEFQR 

      2230       2240       2250       2260       2270       2280 
DVNEFVLWLE EADNVANIPL EPGNEQQLKE KLEQVKLLAE ELPLRQGILK QLNETGGTVL 

      2290       2300       2310       2320       2330       2340 
VSAPLSPEEQ DKLENKLKQT NLQWIKVSRN LPEKQEEIEA HVKDLGQLEE QLNHLLLWLS 

      2350       2360       2370       2380       2390       2400 
PIRNQLEIYN QPNQTGPFDI KEIEVAVQAK QPDVEGILSK GQHLYKEKPA TQPAKRKLED 

      2410       2420       2430       2440       2450       2460 
LSSDWKVVTQ LLQELRAKQP GPAPGLTTVR APPSQTVTLV TQPAVTKETA ISKLEMPSSL 

      2470       2480       2490       2500       2510       2520 
LLEVPALADF NRAWTELTDW LSLLDRVIKS QRVMVGDLED INEMIIKQKA TLQDLEQRRP 

      2530       2540       2550       2560       2570       2580 
QLEELITAAQ NLKNKTSNQE ARTIITDRIE RIQSQWDEVQ EHLQNRRLQL TEMLKDSTQW 

      2590       2600       2610       2620       2630       2640 
LEAKEEAEQV LGQARAKLES WKEAPYTVDA IQKKITETKQ LAKDLRQWQI NVDVANDLAL 

      2650       2660       2670       2680       2690       2700 
KLLRDYSADD TRKVHMITEN INASWASIHK RLSEREAALE ETHRLLQQFP LDLEKFLAWL 

      2710       2720       2730       2740       2750       2760 
TEAETTANVL QDATHKERLL EDSKGVRELM KQWQDLQGEI EAHTDIYHNL DENGQKVLRS 

      2770       2780       2790       2800       2810       2820 
LEGSDDAALL QRRLDNMNFK WSELRKKSLN IRSHLEASSD QWKRLHLSLQ ELLVWLQLKD 

      2830       2840       2850       2860       2870       2880 
DELSRQAPIG GDFPAVQKQN DVHRAFKREL KTKEPVIMST LETVRIFLTE QPLEGLEKLY 

      2890       2900       2910       2920       2930       2940 
QEPRELPPEE RAQNVTRLLR KQAEEVNTQW EKLNVHSADW QRKIDEALER LQELQEATDE 

      2950       2960       2970       2980       2990       3000 
LDLKLRQAEV IKGSWQPVGD LLIDSLQDHL EKVKALRGEI TPLKENVSYV NDLARQLTTL 

      3010       3020       3030       3040       3050       3060 
GIQLSPYNLN TLEDLNTRWK LLQVAIEDRI RQLHEAHRDF GPASQHFLST SVQGPWERAI 

      3070       3080       3090       3100       3110       3120 
SPNKVPYYIN HETQTTCWDH PKMTELYQSL ADLNNVRFSA YRTAMKLRRL QKALCLDLLS 

      3130       3140       3150       3160       3170       3180 
LSAACDALDQ HNLKQNDQPM DILQVINCLT TIYDRLEQEH NNLVNVPLCV DMCLNWLLNV 

      3190       3200       3210       3220       3230       3240 
YDTGRTGRIR VLSFKTGIIS LCKAHLEDKY RYLFKQVASS TGFCDQRRLG LLLHDSIQIP 

      3250       3260       3270       3280       3290       3300 
RQLGEVASFG GSNIEPSVRS CFQFANNKPE IEAALFLDWM RLEPQSMVWL PVLHRVAAAE 

      3310       3320       3330       3340       3350       3360 
TAKHQAKCNI CKECPIIGFR YRSLKHFNYD ICQSCFFSGR VAKGHKMHYP MVEYCTPTTS 

      3370       3380       3390       3400       3410       3420 
GEDVRDFAKV LKNKFRTKRY FAKHPRMGYL PVQTVLEGDN METPVTLINF WPVDSAPASS 

      3430       3440       3450       3460       3470       3480 
PQLSHDDTHS RIEHYASRLK KMENSNGSYL NDSISPNESI DDEHLLIQHY WRSLNQESPL 

      3490       3500       3510       3520       3530       3540 
SQPRSPAQIL ISLESEERGE LERILADLEG RNRNLQAEYD RLKQQHEHKG LSPLPSPPEM 

      3550       3560       3570       3580       3590       3600 
MPTSPQSPRD AELIAEAKLL RQHKGRLEAR MQILEDHNKQ LESQLHRLRQ LLEQPQAEAK 

      3610       3620       3630       3640       3650       3660 
VNGTTVSSPS TSLQRSDSSQ PMLLRVVGSQ TSESMGEEDL LSPPQDTSTG LEEVMEQLNH 

      3670       3680 
SFPSSRGRNT PGKPMREDTM 

« Hide

References

[1]"Alternative dystrophin gene transcripts in golden retriever muscular dystrophy."
Schatzberg S.J., Anderson L.V., Wilton S.D., Kornegay J.N., Mann C.J., Solomon G.G., Sharp N.J.
Muscle Nerve 21:991-998(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
Strain: Golden retriever.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF070485 mRNA. Translation: AAC83646.1.
RefSeqNP_001003343.1. NM_001003343.1.
UniGeneCfa.3738.

3D structure databases

ProteinModelPortalO97592.
SMRO97592. Positions 9-246, 3042-3301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000020300.

Proteomic databases

PaxDbO97592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID606758.
KEGGcfa:606758.

Organism-specific databases

CTD1756.

Phylogenomic databases

eggNOGCOG5069.
HOVERGENHBG005495.
KOK10366.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 16 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFPIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTSM00033. CH. 2 hits.
SM00150. SPEC. 22 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20892530.

Entry information

Entry nameDMD_CANFA
AccessionPrimary (citable) accession number: O97592
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: October 16, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families