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O97592

- DMD_CANFA

UniProt

O97592 - DMD_CANFA

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Protein
Dystrophin
Gene
DMD
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3302 – 334948ZZ-type
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrophin
Gene namesi
Name:DMD
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Cell membranesarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity
Note: In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-SubCell
  4. postsynaptic membrane Source: UniProtKB-SubCell
  5. sarcolemma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 36803680Dystrophin
PRO_0000076074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3478 – 34781Phosphoserine By similarity
Modified residuei3607 – 36071Phosphoserine By similarity
Modified residuei3608 – 36081Phosphoserine By similarity
Modified residuei3612 – 36121Phosphoserine By similarity
Modified residuei3618 – 36181Phosphoserine By similarity
Modified residuei3619 – 36191Phosphoserine By similarity
Modified residuei3661 – 36611Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO97592.

Interactioni

Subunit structurei

Interacts with SYNM. Interacts with the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells By similarity.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020300.

Structurei

3D structure databases

ProteinModelPortaliO97592.
SMRiO97592. Positions 9-246, 3042-3301.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 237237Actin-binding
Add
BLAST
Domaini15 – 119105CH 1
Add
BLAST
Domaini134 – 237104CH 2
Add
BLAST
Repeati340 – 448109Spectrin 1
Add
BLAST
Repeati449 – 557109Spectrin 2
Add
BLAST
Repeati560 – 668109Spectrin 3
Add
BLAST
Repeati720 – 829110Spectrin 4
Add
BLAST
Repeati831 – 935105Spectrin 5
Add
BLAST
Repeati944 – 1047104Spectrin 6
Add
BLAST
Repeati1050 – 1156107Spectrin 7
Add
BLAST
Repeati1159 – 1265107Spectrin 8
Add
BLAST
Repeati1268 – 1369102Spectrin 9
Add
BLAST
Repeati1370 – 146596Spectrin 10
Add
BLAST
Repeati1470 – 1570101Spectrin 11
Add
BLAST
Repeati1573 – 1678106Spectrin 12
Add
BLAST
Repeati1681 – 1780100Spectrin 13
Add
BLAST
Repeati1781 – 187696Spectrin 14
Add
BLAST
Repeati1879 – 1981103Spectrin 15
Add
BLAST
Repeati1994 – 2103110Spectrin 16
Add
BLAST
Repeati2106 – 2210105Spectrin 17
Add
BLAST
Repeati2213 – 2320108Spectrin 18
Add
BLAST
Repeati2321 – 241898Spectrin 19
Add
BLAST
Repeati2470 – 2572103Spectrin 20
Add
BLAST
Repeati2575 – 2681107Spectrin 21
Add
BLAST
Repeati2684 – 2797114Spectrin 22
Add
BLAST
Repeati2803 – 2925123Spectrin 23
Add
BLAST
Repeati2930 – 3035106Spectrin 24
Add
BLAST
Domaini3050 – 308334WW
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 7210ANK2- and ANK-3 binding By similarity
Regioni1418 – 1915498Interaction with SYNM By similarity
Add
BLAST
Regioni3053 – 3403351Interaction with SYNM By similarity
Add
BLAST
Regioni3461 – 351353Binds to SNTB1 By similarity
Add
BLAST

Sequence similaritiesi

Contains 24 spectrin repeats.
Contains 1 WW domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5069.
HOVERGENiHBG005495.
KOiK10366.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 16 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTiSM00033. CH. 2 hits.
SM00150. SPEC. 22 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97592-1 [UniParc]FASTAAdd to Basket

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MLWWEEVEDC YEREDVQKKT FTKWVNAQFS KFGKQHIENL FSDLQDGRRL     50
LDLLEGLTGQ KLPKEKGSTR VHALNNVNKA LRVLQKNNVD LVNIGSTDIV 100
DGNHKLTLGL IWNIILHWQV KNVMKNIMAG LQQTNSEKIL LSWVRQSTRN 150
YPQVNVINFT TSWSDGLALN ALIHSHRPDL FDWNSVVCQQ SATQRLEHAF 200
NIAKYQLGIE KLLDPEDVAT TYPDKKSILM YITSLFQVLP QQVSIEAIQE 250
VEMLPRPSQV TREEHFQIHH QMHYSQQITV SLAQGYERAP SFPKPRFKSY 300
AYTQAAYVTT SDPTRSPLPS QHLETPEDKS FGRSLTETEA NLDSYQTALE 350
EVLSWLLSAE DALQAQGEIS NDVEEVKEQF HTHEGYMMDL TSHQGRVGNV 400
LQLGSQLIGT GKLSEDEETE VQEQMNLLNS RWECLRVASM EKQSNLHKVL 450
MDLQNQQLKE LNDWLTKTEE RTRKMEKEPL GPDIEDLKRQ VQQHKVLQED 500
LEQEQVRVNS LTHMVVVVDE SSGDHATAAL EEQLKVLGDR WANICRWTED 550
RWVLLQDILL KWQRFTEEQC LFSAWLSEKE DAVNKIHTTG FKDQSEVLSN 600
LQKLAVLKTD LEKKKQTMDK LCSLNQDLLS ALKNTVVAHK MEAWLDNFAQ 650
RWDNLVQKLE KSSAQISQAV TTTQPSLTQT TVMETVTMVT TREHILVKHA 700
QEELPPPPPQ KKRQIIVDSE IRKRLDVDIT ELHSWITRSE AVLQSPEFAI 750
YRKEGNFSDL KEKVNAIERE KAEKFRKLQD ASRSAQALVE QMVNEGVNAD 800
SIKQASEQLN SRWIEFCQLL SERLNWLEYQ NNIITFYNQL QQLEQMTTTA 850
ENWLKTQPTT TSEPTAIKSQ LKICKDEINR LSALQPQIER LKIQSIALKE 900
KGQGPMFLDA DFVAFTNHFN QVFADVQARE KELQTIFDSL PPMRYQETMS 950
TILTWIQQSE TKLSIPQVTV TEYDIMEQRL GELQALQSSL QEQQNGLNYL 1000
STTVKEMSKK APLSDISRKY QSEFEEIEGR WKKLSSQLVE HCQKLEEQMA 1050
KLRKIQNHIK TLKKWITEVD VFLKEEWPAL GDSEILKRQL KQCRLLVNDI 1100
QTIQPSLNSV NEGAQKMKNE AEPEFAGRLE TELRELNTQW DYMCRQVYAR 1150
KEALKGGLDK TVSLQKDLSE MHEWMTQAEE EYLERDFEYK TPDELQTAVE 1200
EMKRAKEEAQ QKEAKVKLLT ESVNSVIAQA PPAAQEALKK ELDTLTTNYQ 1250
WLCTRLNGKC KTLEEVWACW HELLSYLEKA NKWLSEVEVK LKTTENISGG 1300
AEEIAEVLDS LENLMQHSED NPNQIRILAQ TLTDGGVMDE LINEELETFN 1350
SRWRELHEEA VRRQKLLEQS IQSAQEIEKS LHLIQESLSS IDKQLAAYIA 1400
DKVDAAQMPQ EAQKIQSDLT SHEISLEEMK KHNQGKETAQ RVLSQIDVAQ 1450
KKLQDVSMKF RLFQKPANFE QRLQESKMIL DEVKMHLPAL ETKSVEQEVV 1500
QSQLNHCVNL YKSLSEVKSE VEMVIKTGRQ IVQKKQTENP KELDERVTAL 1550
KLHYNELGAK VTERKQQLEK CLKLSRKMRK EMNALTEWLA ATDMELTKRS 1600
AVEGMPSNLD SEVAWGKATQ KEIEKQKVHL KSVTEVGEAL KTVLGKKEML 1650
VEDKLSLLNS NWIAVTSRAE EWLNLLLEYQ KHMETFDQNV DYITNWIIQA 1700
DALLDESEKK KPQQKEDILK RLKAEMNDIR PKVDSTRDQA ANLMANRGDH 1750
CRKVVEPKIS ELNHRFAAIS HRIKTGKASI PLKELEQFNS DIQKLLEPLE 1800
AEIQQGVNLK EEDFNKDMSE DNEGTVKELL QRGDNLQQRI TDERKREEIK 1850
IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LLKCLDDIEK 1900
KLASLPEPRD ERKIKEIDRE LQKKKEELNA VRRQAEGLSE DGAAMAVEPT 1950
QIQLSKRWRE IESKFAQFRR LNFAQIHTVH EESVVAMTED MPLEISYVPS 2000
TYLTEITHVS QALSEVEELL NAPDLCAQDF EDLFKQEESL KNIKDSLQQI 2050
SGRIDIIHNK KTAALHSATP AERAKLQEAL SRLDFQWERV NNMYKDRQGR 2100
FDRSVEKWRR FHYDMKILNQ WLTEAEQFLK KTQIPENWEH AKYKWYLKEL 2150
QDGIGQRQSV VRVLNATGEE IIQQSSKTDA SILQEKLGSL NLRWQEVCKQ 2200
LAERKKRLEE QKNILSEFQR DVNEFVLWLE EADNVANIPL EPGNEQQLKE 2250
KLEQVKLLAE ELPLRQGILK QLNETGGTVL VSAPLSPEEQ DKLENKLKQT 2300
NLQWIKVSRN LPEKQEEIEA HVKDLGQLEE QLNHLLLWLS PIRNQLEIYN 2350
QPNQTGPFDI KEIEVAVQAK QPDVEGILSK GQHLYKEKPA TQPAKRKLED 2400
LSSDWKVVTQ LLQELRAKQP GPAPGLTTVR APPSQTVTLV TQPAVTKETA 2450
ISKLEMPSSL LLEVPALADF NRAWTELTDW LSLLDRVIKS QRVMVGDLED 2500
INEMIIKQKA TLQDLEQRRP QLEELITAAQ NLKNKTSNQE ARTIITDRIE 2550
RIQSQWDEVQ EHLQNRRLQL TEMLKDSTQW LEAKEEAEQV LGQARAKLES 2600
WKEAPYTVDA IQKKITETKQ LAKDLRQWQI NVDVANDLAL KLLRDYSADD 2650
TRKVHMITEN INASWASIHK RLSEREAALE ETHRLLQQFP LDLEKFLAWL 2700
TEAETTANVL QDATHKERLL EDSKGVRELM KQWQDLQGEI EAHTDIYHNL 2750
DENGQKVLRS LEGSDDAALL QRRLDNMNFK WSELRKKSLN IRSHLEASSD 2800
QWKRLHLSLQ ELLVWLQLKD DELSRQAPIG GDFPAVQKQN DVHRAFKREL 2850
KTKEPVIMST LETVRIFLTE QPLEGLEKLY QEPRELPPEE RAQNVTRLLR 2900
KQAEEVNTQW EKLNVHSADW QRKIDEALER LQELQEATDE LDLKLRQAEV 2950
IKGSWQPVGD LLIDSLQDHL EKVKALRGEI TPLKENVSYV NDLARQLTTL 3000
GIQLSPYNLN TLEDLNTRWK LLQVAIEDRI RQLHEAHRDF GPASQHFLST 3050
SVQGPWERAI SPNKVPYYIN HETQTTCWDH PKMTELYQSL ADLNNVRFSA 3100
YRTAMKLRRL QKALCLDLLS LSAACDALDQ HNLKQNDQPM DILQVINCLT 3150
TIYDRLEQEH NNLVNVPLCV DMCLNWLLNV YDTGRTGRIR VLSFKTGIIS 3200
LCKAHLEDKY RYLFKQVASS TGFCDQRRLG LLLHDSIQIP RQLGEVASFG 3250
GSNIEPSVRS CFQFANNKPE IEAALFLDWM RLEPQSMVWL PVLHRVAAAE 3300
TAKHQAKCNI CKECPIIGFR YRSLKHFNYD ICQSCFFSGR VAKGHKMHYP 3350
MVEYCTPTTS GEDVRDFAKV LKNKFRTKRY FAKHPRMGYL PVQTVLEGDN 3400
METPVTLINF WPVDSAPASS PQLSHDDTHS RIEHYASRLK KMENSNGSYL 3450
NDSISPNESI DDEHLLIQHY WRSLNQESPL SQPRSPAQIL ISLESEERGE 3500
LERILADLEG RNRNLQAEYD RLKQQHEHKG LSPLPSPPEM MPTSPQSPRD 3550
AELIAEAKLL RQHKGRLEAR MQILEDHNKQ LESQLHRLRQ LLEQPQAEAK 3600
VNGTTVSSPS TSLQRSDSSQ PMLLRVVGSQ TSESMGEEDL LSPPQDTSTG 3650
LEEVMEQLNH SFPSSRGRNT PGKPMREDTM 3680
Length:3,680
Mass (Da):425,653
Last modified:May 1, 1999 - v1
Checksum:i539F1C9D72377872
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070485 mRNA. Translation: AAC83646.1.
RefSeqiNP_001003343.1. NM_001003343.1.
UniGeneiCfa.3738.

Genome annotation databases

GeneIDi606758.
KEGGicfa:606758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070485 mRNA. Translation: AAC83646.1 .
RefSeqi NP_001003343.1. NM_001003343.1.
UniGenei Cfa.3738.

3D structure databases

ProteinModelPortali O97592.
SMRi O97592. Positions 9-246, 3042-3301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000020300.

Proteomic databases

PaxDbi O97592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 606758.
KEGGi cfa:606758.

Organism-specific databases

CTDi 1756.

Phylogenomic databases

eggNOGi COG5069.
HOVERGENi HBG005495.
KOi K10366.

Miscellaneous databases

NextBioi 20892530.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR016344. Dystrophin/utrophin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF00307. CH. 2 hits.
PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 16 hits.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF002341. Dystrophin/utrophin. 1 hit.
SMARTi SM00033. CH. 2 hits.
SM00150. SPEC. 22 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Alternative dystrophin gene transcripts in golden retriever muscular dystrophy."
    Schatzberg S.J., Anderson L.V., Wilton S.D., Kornegay J.N., Mann C.J., Solomon G.G., Sharp N.J.
    Muscle Nerve 21:991-998(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    Strain: Golden retriever.

Entry informationi

Entry nameiDMD_CANFA
AccessioniPrimary (citable) accession number: O97592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: October 16, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi