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Protein

Metalloproteinase inhibitor 3

Gene

TIMP3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei2Involved in metalloproteinase-bindingBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Protein family/group databases

MEROPSiI35.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloproteinase inhibitor 3
Alternative name(s):
Tissue inhibitor of metalloproteinases 3
Short name:
TIMP-3
Gene namesi
Name:TIMP3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000220985‹1 – ›151Metalloproteinase inhibitor 3Add BLAST›151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 108PROSITE-ProRule annotation
Disulfide bondi115 ↔ 120PROSITE-ProRule annotation
Disulfide bondi128 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with EFEMP1.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007183.

Structurei

3D structure databases

ProteinModelPortaliO97590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 108NTRPROSITE-ProRule annotationAdd BLAST›108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Involved in metalloproteinase-bindingBy similarity2
Regioni71 – 151Mediates interaction with EFEMP1By similarityAdd BLAST81

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4745. Eukaryota.
ENOG41103NU. LUCA.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.
InParanoidiO97590.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiView protein in InterPro
IPR001134. Netrin_domain.
IPR001820. TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015612. TIMP3.
IPR027465. TIMP_C.
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF22. PTHR11844:SF22. 1 hit.
PfamiView protein in Pfam
PF00965. TIMP. 1 hit.
SMARTiView protein in SMART
SM00206. NTR. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiView protein in PROSITE
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Fragment.

O97590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CNSDIVIRAK VVGKKLVKEG PFGTMVYTVK QMKMYRGFTK MPHVQYIHTE
60 70 80 90 100
ASESLCGLKL EVNKYQYLLT GRVYDGKVYT GLCNFVERWD QLTLSQRKGL
110 120 130 140 150
NYRYHLGCNC KIKSCYYLPC FVTSKNECLW TDMLSNFGYP GYQSKHYACI

R
Length:151
Mass (Da):17,595
Last modified:May 1, 1999 - v1
Checksum:iB5BAC65EFF0AC6EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1511

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069714 mRNA. Translation: AAC95006.1.
UniGeneiOcu.2315.

Similar proteinsi

Entry informationi

Entry nameiTIMP3_RABIT
AccessioniPrimary (citable) accession number: O97590
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families