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Protein

Metalloproteinase inhibitor 3

Gene

TIMP3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Protein family/group databases

MEROPSiI35.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloproteinase inhibitor 3
Alternative name(s):
Tissue inhibitor of metalloproteinases 3
Short name:
TIMP-3
Gene namesi
Name:TIMP3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›151›151Metalloproteinase inhibitor 3PRO_0000220985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1 ↔ 108PROSITE-ProRule annotation
Disulfide bondi115 ↔ 120PROSITE-ProRule annotation
Disulfide bondi128 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with EFEMP1.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007183.

Structurei

3D structure databases

ProteinModelPortaliO97590.
SMRiO97590. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 108›108NTRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Involved in metalloproteinase-bindingBy similarity
Regioni71 – 15181Mediates interaction with EFEMP1By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 NTR domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4745. Eukaryota.
ENOG41103NU. LUCA.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.
InParanoidiO97590.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiIPR001134. Netrin_domain.
IPR001820. TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015612. TIMP3.
IPR027465. TIMP_C.
[Graphical view]
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF22. PTHR11844:SF22. 1 hit.
PfamiPF00965. TIMP. 1 hit.
[Graphical view]
SMARTiSM00206. NTR. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O97590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CNSDIVIRAK VVGKKLVKEG PFGTMVYTVK QMKMYRGFTK MPHVQYIHTE
60 70 80 90 100
ASESLCGLKL EVNKYQYLLT GRVYDGKVYT GLCNFVERWD QLTLSQRKGL
110 120 130 140 150
NYRYHLGCNC KIKSCYYLPC FVTSKNECLW TDMLSNFGYP GYQSKHYACI

R
Length:151
Mass (Da):17,595
Last modified:May 1, 1999 - v1
Checksum:iB5BAC65EFF0AC6EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei151 – 1511

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069714 mRNA. Translation: AAC95006.1.
UniGeneiOcu.2315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069714 mRNA. Translation: AAC95006.1.
UniGeneiOcu.2315.

3D structure databases

ProteinModelPortaliO97590.
SMRiO97590. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007183.

Protein family/group databases

MEROPSiI35.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4745. Eukaryota.
ENOG41103NU. LUCA.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.
InParanoidiO97590.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiIPR001134. Netrin_domain.
IPR001820. TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015612. TIMP3.
IPR027465. TIMP_C.
[Graphical view]
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF22. PTHR11844:SF22. 1 hit.
PfamiPF00965. TIMP. 1 hit.
[Graphical view]
SMARTiSM00206. NTR. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Temporal alterations in mRNA levels for proteinases and inhibitors and their potential regulators in the healing medial collateral ligament."
    Reno C., Boykiw R., Martinez M.L., Hart D.A.
    Biochem. Biophys. Res. Commun. 252:757-763(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.

Entry informationi

Entry nameiTIMP3_RABIT
AccessioniPrimary (citable) accession number: O97590
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.