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O97578

- CATC_CANFA

UniProt

O97578 - CATC_CANFA

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Protein

Dipeptidyl peptidase 1

Gene

CTSC

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

Binds 1 chloride ion per heavy chain.By similarity

pH dependencei

Optimum pH is 6.5. Active over a broad pH range.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei231 – 2311By similarity
Binding sitei275 – 2751ChlorideBy similarity
Binding sitei277 – 2771Chloride; via amide nitrogenBy similarity
Binding sitei319 – 3191ChlorideBy similarity
Active sitei377 – 3771By similarity
Active sitei399 – 3991By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Chloride

Protein family/group databases

MEROPSiC01.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 1 (EC:3.4.14.1)
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name:
DPP-I
Short name:
DPPI
Dipeptidyl transferase
Cleaved into the following 6 chains:
Alternative name(s):
Dipeptidyl peptidase I exclusion domain chain
Alternative name(s):
Dipeptidyl peptidase I heavy chain 1
Alternative name(s):
Dipeptidyl peptidase I heavy chain 2
Alternative name(s):
Dipeptidyl peptidase I heavy chain 3
Alternative name(s):
Dipeptidyl peptidase I heavy chain 4
Alternative name(s):
Dipeptidyl peptidase I light chain
Gene namesi
Name:CTSC
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109109Dipeptidyl peptidase 1 exclusion domain chainBy similarityPRO_0000026331Add
BLAST
Propeptidei110 – 19990By similarityPRO_0000026332Add
BLAST
Chaini200 – 366167Dipeptidyl peptidase 1 heavy chain 1PRO_0000026333Add
BLAST
Chaini201 – 366166Dipeptidyl peptidase 1 heavy chain 2PRO_0000026334Add
BLAST
Chaini203 – 366164Dipeptidyl peptidase 1 heavy chain 3PRO_0000026335Add
BLAST
Chaini204 – 366163Dipeptidyl peptidase 1 heavy chain 4PRO_0000026336Add
BLAST
Chaini367 – 43569Dipeptidyl peptidase 1 light chainPRO_0000026337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)By similarity
Disulfide bondi6 ↔ 93By similarity
Glycosylationi28 – 281N-linked (GlcNAc...)By similarity
Disulfide bondi29 ↔ 111By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)By similarity
Disulfide bondi228 ↔ 271By similarity
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi264 ↔ 304By similarity
Disulfide bondi294 ↔ 309By similarity

Post-translational modificationi

The N-terminus of the heavy chain is heterogeneously processed to produce four different chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO97578.
PRIDEiO97578.

Interactioni

Subunit structurei

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000006531.

Structurei

3D structure databases

ProteinModelPortaliO97578.
SMRiO97578. Positions 1-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG4870.
HOGENOMiHOG000068022.
HOVERGENiHBG005248.
InParanoidiO97578.
KOiK01275.

Family and domain databases

Gene3Di2.40.128.80. 1 hit.
InterProiIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMiSSF75001. SSF75001. 1 hit.
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97578-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DTPANCTHPE LLGTWVFQVG PAGSRSVNCS VMGPPEKKVV VHLEKLDTAY
60 70 80 90 100
DNFGNTGHFT IIYNQGFEIV LNDYKWFAFF KYKEEGHKVT SYCNETMTGW
110 120 130 140 150
VHDVLGRNWA CFTGTKMGTT SEKAKVNTKH IERLQENNSN RLYKYNYEFV
160 170 180 190 200
KAINTIQKSW TATRYIEYET LTLRDMMTRV GGRKIPRPKP TPLTAEIHEE
210 220 230 240 250
ISRLPTSWDW RNVRGTNFVS PVRNQASCGS CYAFASTAML EARIRILTNN
260 270 280 290 300
TQTPILSPQE IVSCSQYAQG CEGGFPYLIA GKYAQDFGLV EEACFPYAGS
310 320 330 340 350
DSPCKPNDCF RYYSSEYYYV GGFYGACNEA LMKLELVRHG PMAVAFEVYD
360 370 380 390 400
DFFHYQKGIY YHTGLRDPFN PFELTNHAVL LVGYGTDSAS GMDYWIVKNS
410 420 430
WGSRWGEDGY FRIRRGTDEC AIESIAVAAT PIPKL
Length:435
Mass (Da):49,412
Last modified:May 1, 1999 - v1
Checksum:iA80BC7C68CAB0727
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060171 mRNA. Translation: AAD02704.1.
RefSeqiNP_001182763.1. NM_001195834.1.
UniGeneiCfa.28653.

Genome annotation databases

GeneIDi403458.
KEGGicfa:403458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060171 mRNA. Translation: AAD02704.1 .
RefSeqi NP_001182763.1. NM_001195834.1.
UniGenei Cfa.28653.

3D structure databases

ProteinModelPortali O97578.
SMRi O97578. Positions 1-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000006531.

Protein family/group databases

MEROPSi C01.070.

Proteomic databases

PaxDbi O97578.
PRIDEi O97578.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403458.
KEGGi cfa:403458.

Organism-specific databases

CTDi 1075.

Phylogenomic databases

eggNOGi COG4870.
HOGENOMi HOG000068022.
HOVERGENi HBG005248.
InParanoidi O97578.
KOi K01275.

Miscellaneous databases

NextBioi 20816976.

Family and domain databases

Gene3Di 2.40.128.80. 1 hit.
InterProi IPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00645. Pept_C1. 1 hit.
[Graphical view ]
SUPFAMi SSF75001. SSF75001. 1 hit.
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I."
    Wolters P.J., Raymond W.W., Blount J.L., Caughey G.H.
    J. Biol. Chem. 273:15514-15520(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-8 AND 199-208.
    Tissue: Mast cell.

Entry informationi

Entry nameiCATC_CANFA
AccessioniPrimary (citable) accession number: O97578
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3