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Protein

Mitochondrial uncoupling protein 2

Gene

UCP2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-SSC-167826. The fatty acid cycling model.
R-SSC-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
Gene namesi
Name:UCP2
Synonyms:SLC25A8
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial matrixSequence analysis10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 77Mitochondrial intermembraneSequence analysisAdd BLAST45
Transmembranei78 – 100Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini101 – 119Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini137 – 180Mitochondrial intermembraneSequence analysisAdd BLAST44
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial intermembraneSequence analysisAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial matrixSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906661 – 309Mitochondrial uncoupling protein 2Add BLAST309

Proteomic databases

PaxDbiO97562.
PeptideAtlasiO97562.
PRIDEiO97562.

Expressioni

Gene expression databases

BgeeiENSSSCG00000014833.
GenevisibleiO97562. SS.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015752.

Structurei

3D structure databases

ProteinModelPortaliO97562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 106Solcar 1Add BLAST96
Repeati114 – 203Solcar 2Add BLAST90
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 298Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiO97562.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFKATEVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGERRGP
60 70 80 90 100
VQAAASAQYR GVLGTILTMV RNEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKHFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYRSTV DAYKTIAREE GLRGLWKGTS PNVARNAIVN CAELVTYDLI
210 220 230 240 250
KDTLLKADLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSAPGQY
260 270 280 290 300
SSAGHCALTM LQKEGPRAFY KGFTPSFLRL GSWNVVMFVT YEQLKRALMA

ARASREAPF
Length:309
Mass (Da):33,259
Last modified:May 1, 1999 - v1
Checksum:i7A67D59946DA21BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036757 mRNA. Translation: AAD05201.1.
AY739703 Genomic DNA. Translation: AAU94639.1.
DQ530365 mRNA. Translation: ABF74757.1.
DQ530367 mRNA. Translation: ABF74759.1.
RefSeqiNP_999454.1. NM_214289.1.
XP_005667155.1. XM_005667098.2.
UniGeneiSsc.16350.

Genome annotation databases

EnsembliENSSSCT00000016185; ENSSSCP00000015752; ENSSSCG00000014833.
GeneIDi397549.
KEGGissc:397549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036757 mRNA. Translation: AAD05201.1.
AY739703 Genomic DNA. Translation: AAU94639.1.
DQ530365 mRNA. Translation: ABF74757.1.
DQ530367 mRNA. Translation: ABF74759.1.
RefSeqiNP_999454.1. NM_214289.1.
XP_005667155.1. XM_005667098.2.
UniGeneiSsc.16350.

3D structure databases

ProteinModelPortaliO97562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015752.

Proteomic databases

PaxDbiO97562.
PeptideAtlasiO97562.
PRIDEiO97562.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000016185; ENSSSCP00000015752; ENSSSCG00000014833.
GeneIDi397549.
KEGGissc:397549.

Organism-specific databases

CTDi7351.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiO97562.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiR-SSC-167826. The fatty acid cycling model.
R-SSC-167827. The proton buffering model.

Gene expression databases

BgeeiENSSSCG00000014833.
GenevisibleiO97562. SS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCP2_PIG
AccessioniPrimary (citable) accession number: O97562
Secondary accession number(s): Q19B01, Q5XQS5, Q9GK29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.