Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial uncoupling protein 2

Gene

UCP2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-SSC-167826 The fatty acid cycling model
R-SSC-167827 The proton buffering model

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
Gene namesi
Name:UCP2
Synonyms:SLC25A8
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial matrixSequence analysis10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 77Mitochondrial intermembraneSequence analysisAdd BLAST45
Transmembranei78 – 100Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini101 – 119Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini137 – 180Mitochondrial intermembraneSequence analysisAdd BLAST44
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial intermembraneSequence analysisAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial matrixSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906661 – 309Mitochondrial uncoupling protein 2Add BLAST309

Proteomic databases

PaxDbiO97562
PeptideAtlasiO97562
PRIDEiO97562

Expressioni

Gene expression databases

BgeeiENSSSCG00000014833
GenevisibleiO97562 SS

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015752

Structurei

3D structure databases

ProteinModelPortaliO97562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 106Solcar 1Add BLAST96
Repeati114 – 203Solcar 2Add BLAST90
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 298Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiO97562
KOiK15103
OMAiSEHAGIG
OrthoDBiEOG091G0BQ7
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

O97562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFKATEVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGERRGP
60 70 80 90 100
VQAAASAQYR GVLGTILTMV RNEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKHFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYRSTV DAYKTIAREE GLRGLWKGTS PNVARNAIVN CAELVTYDLI
210 220 230 240 250
KDTLLKADLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSAPGQY
260 270 280 290 300
SSAGHCALTM LQKEGPRAFY KGFTPSFLRL GSWNVVMFVT YEQLKRALMA

ARASREAPF
Length:309
Mass (Da):33,259
Last modified:May 1, 1999 - v1
Checksum:i7A67D59946DA21BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036757 mRNA Translation: AAD05201.1
AY739703 Genomic DNA Translation: AAU94639.1
DQ530365 mRNA Translation: ABF74757.1
DQ530367 mRNA Translation: ABF74759.1
RefSeqiNP_999454.1, NM_214289.1
XP_005667155.1, XM_005667098.2
UniGeneiSsc.16350

Genome annotation databases

GeneIDi397549
KEGGissc:397549

Similar proteinsi

Entry informationi

Entry nameiUCP2_PIG
AccessioniPrimary (citable) accession number: O97562
Secondary accession number(s): Q19B01, Q5XQS5, Q9GK29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health