Reviewed,
UniProtKB/Swiss-Prot O97524 (BGLR_FELCA)
Last modified
June 16, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Beta-glucuronidase EC=3.2.1.31 | ||
| Gene names |
| ||
| Organism | Felis silvestris catus (Cat) | ||
| Taxonomic identifier | 9685 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Protein attributes
| Sequence length | 651 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays an important role in the degradation of dermatan and keratan sulfates. |
| Catalytic activity | A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol. |
| Enzyme regulation | Inhibited by L-aspartic acid By similarity. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | |
| Involvement in disease | Defects in GUSB are the cause of mucopolysaccharidosis type VII (MPS VII), an inherited disease reported in humans, mice, cats, and dogs. Ref.1 |
| Sequence similarities | Belongs to the glycosyl hydrolase 2 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Disease | Disease mutation |
| Domain | Signal |
| Molecular function | Glycosidase Hydrolase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | beta-glucuronidase activity Inferred from electronic annotation. Source: EC cation bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | By similarity | ||||||
| Chain | 23 – 651 | 629 | Beta-glucuronidase | PRO_0000012160 | |||||
Sites | |||||||||
| Active site | 450 | 1 | Proton donor By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 172 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 419 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 630 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 351 | 1 | E → K in MPS VII. Ref.1 | ||||||
Sequences
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References
| [1] | "Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII." Fyfe J.C., Kurzhals R.L., Lassaline M.E., Henthorn P.S., Alur P.R., Wang P., Wolfe J.H., Giger U., Haskins M.E., Patterson D.F., Sun H., Jain S., Yuhki N. Genomics 58:121-128(1999) [PubMed: 10366443] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MPS VII LYS-351. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| AF012423 mRNA. Translation: AAD01498.1. AF012424 mRNA. Translation: AAD01499.1. | |
| RefSeq | NP_001009310.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BHG based on UniProtKB P08236. |
| SMR | O97524. Positions 22-631. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GH2. Glycoside Hydrolase Family 2. |
Genome annotation databases | |
| GeneID | 493879. |
Phylogenomic databases | |
| HOVERGEN | O97524. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.31. 273949. |
Family and domain databases | |
| InterPro | IPR006101. Glyco_hydro_2. IPR013812. Glyco_hydro_2/20_Ig-like. IPR006104. Glyco_hydro_2_carb-bd. IPR006102. Glyco_hydro_2_Ig-like. IPR006103. Glyco_hydro_2_TIM. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view] |
| Gene3D | G3DSA:2.60.40.320. Glyco_hydro_2/20_Ig-like. 1 hit. G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit. |
| Pfam | PF00703. Glyco_hydro_2. 1 hit. PF02836. Glyco_hydro_2_C. 1 hit. PF02837. Glyco_hydro_2_N. 1 hit. [Graphical view] |
| PRINTS | PR00132. GLHYDRLASE2. |
| PROSITE | PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit. PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BGLR_FELCA | ||||||||
| Accession | Primary (citable) accession number: O97524 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


