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Protein

Neuromedin-K receptor

Gene

TACR3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-K receptor
Short name:
NKR
Alternative name(s):
NK-3 receptor
Short name:
NK-3R
Neurokinin B receptor
Tachykinin receptor 3
Gene namesi
Name:TACR3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686ExtracellularSequence analysisAdd
BLAST
Transmembranei87 – 10923Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini110 – 11910CytoplasmicSequence analysis
Transmembranei120 – 14122Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini142 – 16120ExtracellularSequence analysisAdd
BLAST
Transmembranei162 – 18322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini184 – 20320CytoplasmicSequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini225 – 24723ExtracellularSequence analysisAdd
BLAST
Transmembranei248 – 27225Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini273 – 30129CytoplasmicSequence analysisAdd
BLAST
Transmembranei302 – 32322Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini324 – 33613ExtracellularSequence analysisAdd
BLAST
Transmembranei337 – 36125Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini362 – 467106CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Neuromedin-K receptorPRO_0000069901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi160 ↔ 235PROSITE-ProRule annotation
Lipidationi376 – 3761S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiO97512.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008258.

Structurei

3D structure databases

ProteinModelPortaliO97512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiO97512.
KOiK04224.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR001013. NK3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01026. NEUROKININ3R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSFAAAETW TDAAGGAGAD GRNLSAALAA GAAAEALGTE WLQLLVQAGN
60 70 80 90 100
LSSSLPSSVP GLPTTSPAPS QPRANLTNQF VQPSWRIALW SLAYGVVVAV
110 120 130 140 150
AVFGNLIVIW IILAHKRMRT VTNYFLVNLA FSDASMAAFN TLVNFIYALH
160 170 180 190 200
SEWYFGANYC RFQNFFPITA VFASIYSMTA IAVDRYMAII DPLKPRLSAT
210 220 230 240 250
ATKIVIGSIW ILAFLLALPQ CLYSKTKVMP GRTLCYVQWP EGPKQHFIYH
260 270 280 290 300
IIVIILVYCF PLLIMGITYT IVGITLWGGE IPGDTCDKYH EQLKAKRKVV
310 320 330 340 350
KMMIIVVVTF AICWLPYHIY FILTAIYQQL NRWKYIQQVY LASFWLAMSS
360 370 380 390 400
TMYNPIIYCC LNKRFRAGFK RAFRWCPFIQ VSSYDELELK TTRFHPTRQS
410 420 430 440 450
SLYTVTRMES MTVVFDPSDA DNTRSSRKKR ATPGDPNFNG CSRRNSKSAS
460
TTSSFISSPY TSMEEYS
Length:467
Mass (Da):52,450
Last modified:November 1, 1999 - v2
Checksum:i4FE21F2F86549BAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133908 mRNA. Translation: AAD01408.2.
RefSeqiNP_001075524.1. NM_001082055.1.
UniGeneiOcu.2357.

Genome annotation databases

GeneIDi100008721.
KEGGiocu:100008721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133908 mRNA. Translation: AAD01408.2.
RefSeqiNP_001075524.1. NM_001082055.1.
UniGeneiOcu.2357.

3D structure databases

ProteinModelPortaliO97512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008258.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiO97512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008721.
KEGGiocu:100008721.

Organism-specific databases

CTDi6870.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiO97512.
KOiK04224.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR001013. NK3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01026. NEUROKININ3R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNK3R_RABIT
AccessioniPrimary (citable) accession number: O97512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.