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Protein

Melanocortin receptor 4

Gene

MC4R

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP) (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 4
Short name:
MC4-R
Gene namesi
Name:MC4R
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6926Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini70 – 8112CytoplasmicSequence analysisAdd
BLAST
Transmembranei82 – 10625Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini107 – 12317ExtracellularSequence analysisAdd
BLAST
Transmembranei124 – 14522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini146 – 16520CytoplasmicSequence analysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini187 – 1915ExtracellularSequence analysis
Transmembranei192 – 21524Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 24833CytoplasmicSequence analysisAdd
BLAST
Transmembranei249 – 27123Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini272 – 2809ExtracellularSequence analysis
Transmembranei281 – 30424Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini305 – 33228CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Melanocortin receptor 4PRO_0000069725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi84 – 84InterchainPROSITE-ProRule annotation
Lipidationi318 – 3181S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO97504.

Interactioni

Subunit structurei

Interacts with ATRNL1 (By similarity). Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005275.

Structurei

3D structure databases

ProteinModelPortaliO97504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiO97504.
KOiK04202.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000155. Mcort_rcpt_4.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01062. MELNOCORTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTHHHGMH TSLHFWNRST YGLHSNASEP LGKGYSEGGC YEQLFVSPEV
60 70 80 90 100
FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE
110 120 130 140 150
TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT
160 170 180 190 200
IFYALQYHNI MTVKRVGIII SCIWAVCTVS GVLFIIYSDS SAVIICLITV
210 220 230 240 250
FFTMLALMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGAN MKGAITLTIL
260 270 280 290 300
IGVFVVCWAP FFLHLIFYIS CPQNPYCVCF MSHFNLYLIL IMCNSIIDPL
310 320 330
IYALRSQELR KTFKEIICCY PLGGLCDLSS RY
Length:332
Mass (Da):36,947
Last modified:May 1, 1999 - v1
Checksum:i5CD1CD67008BFC81
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti298 – 2981D → N Associated with less backfat thickness, slower growth rate and lower feed intake. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021664 mRNA. Translation: BAA36170.1.
DQ388767 mRNA. Translation: ABD28176.1.
AF087937 Genomic DNA. Translation: AAF31753.1.
AF227727 mRNA. Translation: AAF34778.1.
RefSeqiNP_999338.1. NM_214173.1.
UniGeneiSsc.16081.

Genome annotation databases

GeneIDi397359.
KEGGissc:397359.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021664 mRNA. Translation: BAA36170.1.
DQ388767 mRNA. Translation: ABD28176.1.
AF087937 Genomic DNA. Translation: AAF31753.1.
AF227727 mRNA. Translation: AAF34778.1.
RefSeqiNP_999338.1. NM_214173.1.
UniGeneiSsc.16081.

3D structure databases

ProteinModelPortaliO97504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005275.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO97504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397359.
KEGGissc:397359.

Organism-specific databases

CTDi4160.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiO97504.
KOiK04202.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000155. Mcort_rcpt_4.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01062. MELNOCORTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Ito Y., Minezawa M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Large white X Duroc.
    Tissue: Kidney.
  2. "The comparative analysis on MC4R gene of wild boar, domestic pig and their crossbred."
    Yang X.Q., Yu H., Liu D.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits."
    Kim K.S., Larsen N., Short T., Plastow G., Rothschild M.F.
    Mamm. Genome 11:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-320, VARIANT ASN-298.
  4. Matteri R.L., Dyer C.J.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-142.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiMC4R_PIG
AccessioniPrimary (citable) accession number: O97504
Secondary accession number(s): Q2EF33, Q9N141, Q9N274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.