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O97492

- CATA_CANFA

UniProt

O97492 - CATA_CANFA

Protein

Catalase

Gene

CAT

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

    Cofactori

    Heme group.By similarity
    NADP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751PROSITE-ProRule annotation
    Active sitei148 – 1481PROSITE-ProRule annotation
    Metal bindingi358 – 3581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. catalase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW
    2. positive regulation of cell division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Mitogen, Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Protein family/group databases

    PeroxiBasei5319. CfaKat01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catalase (EC:1.11.1.6)
    Gene namesi
    Name:CAT
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 18

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    Pathology & Biotechi

    Involvement in diseasei

    Defects in CAT are the cause of acatalasia; also known as acatalasemia. This disease is characterized by absence of catalase activity.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 527526CatalasePRO_0000084899Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei13 – 131N6-succinyllysineBy similarity
    Modified residuei221 – 2211N6-succinyllysineBy similarity
    Modified residuei233 – 2331N6-acetyllysineBy similarity
    Modified residuei434 – 4341PhosphoserineBy similarity
    Modified residuei449 – 4491N6-acetyllysine; alternateBy similarity
    Modified residuei449 – 4491N6-succinyllysine; alternateBy similarity
    Modified residuei480 – 4801N6-acetyllysine; alternateBy similarity
    Modified residuei480 – 4801N6-succinyllysine; alternateBy similarity
    Modified residuei499 – 4991N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiO97492.
    PRIDEiO97492.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000010324.

    Structurei

    3D structure databases

    ProteinModelPortaliO97492.
    SMRiO97492. Positions 4-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.Curated

    Phylogenomic databases

    eggNOGiCOG0753.
    GeneTreeiENSGT00390000018100.
    HOGENOMiHOG000087852.
    HOVERGENiHBG003986.
    InParanoidiO97492.
    KOiK03781.
    OMAiNASQFIQ.
    OrthoDBiEOG7V7660.
    TreeFamiTF300540.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O97492-1 [UniParc]FASTAAdd to Basket

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    MADSRDPASD QMKLWKEQRA AQKPDVLTTG GGNPIGDKLN VMTAGPRGPL    50
    LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF 100
    EHIGKRTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT 150
    PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF 200
    SDRGIPDGHR HMNGYGSHTF KLVNAAGEAV YCKFHYKTDQ GIKNLSVEDA 250
    ARLSHEDPDY GLRDLFNAIA TGNYPSWTFY IQVMTFSQAE TFPFNPFDLT 300
    KIWPHQDYPL IPVGKLVLNR NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM 350
    LQGRLFAYPD THRHRLGPNY LQIPVNCPFR ARVANYQRDG PMCMLDNQGG 400
    APNYYPNSFS APEQQRCVLE HSSQCSPDVQ RFNSANEDNV TQVRTFYLKV 450
    LGEEERKRLC ENIAGHLKDA QLFIQKKAVK NFSDVHPDYG ARIQALLDKY 500
    NAEKPKNAIH TFMQHGSHLA AREKANL 527
    Length:527
    Mass (Da):59,797
    Last modified:January 23, 2007 - v3
    Checksum:iCC0BC7F88FE2C2AC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti327 – 3271A → T in acatalasemia; heat-labile. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012918 mRNA. Translation: BAA36420.1.
    AB038231 mRNA. Translation: BAB20764.1.
    RefSeqiNP_001002984.1. NM_001002984.1.
    UniGeneiCfa.188.

    Genome annotation databases

    EnsembliENSCAFT00000011146; ENSCAFP00000010324; ENSCAFG00000006941.
    GeneIDi403474.
    KEGGicfa:403474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012918 mRNA. Translation: BAA36420.1 .
    AB038231 mRNA. Translation: BAB20764.1 .
    RefSeqi NP_001002984.1. NM_001002984.1.
    UniGenei Cfa.188.

    3D structure databases

    ProteinModelPortali O97492.
    SMRi O97492. Positions 4-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000010324.

    Protein family/group databases

    PeroxiBasei 5319. CfaKat01.

    Proteomic databases

    PaxDbi O97492.
    PRIDEi O97492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000011146 ; ENSCAFP00000010324 ; ENSCAFG00000006941 .
    GeneIDi 403474.
    KEGGi cfa:403474.

    Organism-specific databases

    CTDi 847.

    Phylogenomic databases

    eggNOGi COG0753.
    GeneTreei ENSGT00390000018100.
    HOGENOMi HOG000087852.
    HOVERGENi HBG003986.
    InParanoidi O97492.
    KOi K03781.
    OMAi NASQFIQ.
    OrthoDBi EOG7V7660.
    TreeFami TF300540.

    Miscellaneous databases

    NextBioi 20816990.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequences of dog catalase."
      Nakamura K., Watanabe M., Ikeda T.
      DNA Seq. 9:347-352(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.
    2. "cDNA cloning of mutant catalase in acatalasemic beagle dog: single nucleotide substitution leading to thermal-instability and enhanced proteolysis of mutant enzyme."
      Nakamura K., Watanabe M., Takanaka K., Sasaki Y., Ikeda T.
      Int. J. Biochem. Cell Biol. 32:1183-1193(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ACATALASEMIA THR-327.
      Strain: Beagle.

    Entry informationi

    Entry nameiCATA_CANFA
    AccessioniPrimary (citable) accession number: O97492
    Secondary accession number(s): Q9GKY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3