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Protein

Melanotransferrin

Gene

MELTF

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron 1PROSITE-ProRule annotation
Metal bindingi107 – 1071Iron 1PROSITE-ProRule annotation
Binding sitei132 – 1321Carbonate 1PROSITE-ProRule annotation
Binding sitei136 – 1361Carbonate 1PROSITE-ProRule annotation
Binding sitei138 – 1381Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Binding sitei139 – 1391Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Metal bindingi210 – 2101Iron 1PROSITE-ProRule annotation
Metal bindingi279 – 2791Iron 1PROSITE-ProRule annotation
Metal bindingi451 – 4511Iron 2PROSITE-ProRule annotation
Metal bindingi625 – 6251Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding, Zinc

Protein family/group databases

MEROPSiS60.976.

Names & Taxonomyi

Protein namesi
Recommended name:
MelanotransferrinBy similarity
Alternative name(s):
Membrane-bound transferrin-like protein p97
CD_antigen: CD228
Gene namesi
Name:MELTFBy similarity
Synonyms:MFI2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 711692MelanotransferrinPRO_0000035743Add
BLAST
Propeptidei712 – 73625Removed in mature formSequence analysisPRO_0000035744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 63PROSITE-ProRule annotation
Disulfide bondi36 ↔ 54PROSITE-ProRule annotation
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi130 ↔ 216PROSITE-ProRule annotation
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi172 ↔ 189PROSITE-ProRule annotation
Disulfide bondi186 ↔ 199PROSITE-ProRule annotation
Disulfide bondi257 ↔ 271PROSITE-ProRule annotation
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence analysis
Lipidationi711 – 7111GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiO97490.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011582.

Structurei

3D structure databases

ProteinModelPortaliO97490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 357335Transferrin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini366 – 706341Transferrin-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiO97490.
KOiK06569.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 1 hit.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCRSAAMWI FLALRTALGS VEVRWCTASE PEQQKCEDMS QAFREAGLQP
60 70 80 90 100
ALLCVQGTSA DHCVQLIAAH EADAITLDGG AIYEAGKEHG LKPVVGEVYD
110 120 130 140 150
QEVGTSYYAV AVVKRSSNVT INTLRGVKSC HTGINRTVGW NVPVGYLVDS
160 170 180 190 200
GRLSVMGCDV LKAVSEYFGG SCVPGAGETR YSESLCRLCR GDTSGEGVCD
210 220 230 240 250
KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGRT LPSWGHMLMS
260 270 280 290 300
RDFELLCRDG SRASVTEWQH CHLARVPAHA VVVRADTDAG LIFRLLNEGQ
310 320 330 340 350
RLFSHEGSSF QMFSSEAYGQ KNLLFKDSTL ELVPIATQTY EAWLGPEYLH
360 370 380 390 400
AMKGLLCDPN RLPPYLRWCV LSTPEIQKCG DMAVAFSRQR LKPEIQCVSA
410 420 430 440 450
ESPQHCMEQI QAGHIDAVTL NGEDIHTAGK TYGLIPAAGE LYAADDRSNS
460 470 480 490 500
YFVVAVVKRD SAYAFTVDEL RGKRSCHPGF GSPAGWDVPV GALIHWGYIR
510 520 530 540 550
PRNCDVLTAV GQFFNASCVP VNNPKKYPSS LCALCVGDEQ GRNKCTGNSQ
560 570 580 590 600
ERYYGDSGAF RCLVEGAGDV AFVKHTTIFD NTNGHNPEPW AAHLRSQDYE
610 620 630 640 650
LLCPNGARAE AHQFAACNLA QIPSHAVMVR PDTNIFTVYG LLDKAQDLFG
660 670 680 690 700
DDHNKNGFKM FDSSSYHGRD LLFKDATVRA VPVGERTTYQ DWLGPDYVAA
710 720 730
LEGMQSQRCS GAAVGAPGAS LLPLLPLAVG LLLSSL
Length:736
Mass (Da):80,170
Last modified:May 1, 1999 - v1
Checksum:iF389D9F8A6AC90FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010995 mRNA. Translation: BAA33956.1.
RefSeqiNP_001075461.1. NM_001081992.1.
UniGeneiOcu.2304.

Genome annotation databases

GeneIDi100008603.
KEGGiocu:100008603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010995 mRNA. Translation: BAA33956.1.
RefSeqiNP_001075461.1. NM_001081992.1.
UniGeneiOcu.2304.

3D structure databases

ProteinModelPortaliO97490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011582.

Protein family/group databases

MEROPSiS60.976.

Proteomic databases

PRIDEiO97490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008603.
KEGGiocu:100008603.

Organism-specific databases

CTDi30060.

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiO97490.
KOiK06569.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 1 hit.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of membrane-bound transferrin-like protein p97 on the cell surface of chondrocyte."
    Kawamoto T., Pan H., Yan W., Ishida H., Usui E., Oda R., Nakamasu K., Noshiro M., Kawashima-Ohya Y., Fujii M., Shintani H., Okada Y., Kato Y.
    Eur. J. Biochem. 256:503-509(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTRFM_RABIT
AccessioniPrimary (citable) accession number: O97490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.