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Protein

Major royal jelly protein 5

Gene

MRJP5

Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in honeybee nutrition. It is found in the royal jelly which is the food of the queen honey bee larva. The royal jelly determines the development of the young larvae and is responsible for the high reproductive ability of the honeybee queen.

Names & Taxonomyi

Protein namesi
Recommended name:
Major royal jelly protein 5
Short name:
MRJP-5
Alternative name(s):
Bee-milk protein
Gene namesi
Name:MRJP5
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 598581Major royal jelly protein 5PRO_0000031047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO97432.
PRIDEiO97432.

Expressioni

Tissue specificityi

Hypopharyngeal glands of nurse honey bees.

Developmental stagei

Produced by the cephalic glandular system of the nurse honey bee.

Structurei

3D structure databases

ProteinModelPortaliO97432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major royal jelly protein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KG2T. Eukaryota.
ENOG4110SQU. LUCA.
InParanoidiO97432.
PhylomeDBiO97432.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR017996. Royal_jelly/Protein_yellow.
[Graphical view]
PANTHERiPTHR10009. PTHR10009. 1 hit.
PfamiPF03022. MRJP. 2 hits.
[Graphical view]
PRINTSiPR01366. ROYALJELLY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTWLLLVVC LGIACQGITS VTVRENSPRK LANSMNVIHE WKYLDYDFGS
60 70 80 90 100
DERRQAAMQS GEYDHTKNYP FDVDQWRGMT FVTVPRYKGV PSSLNVISEK
110 120 130 140 150
IGNGGRLLQP YPDWSWANYK DCSGIVSAYK IAIDKFDRLW ILDSGIINNT
160 170 180 190 200
QPMCSPKLHV FDLNTSHQLK QVVMPHDIAV NASTGNGGLV SLVVQAMDPV
210 220 230 240 250
NTIVYMADDK GDALIVYQNS DESFHRLTSN TFDYDPKYIK MMDAGESFTA
260 270 280 290 300
QDGIFGMALS PMTNNLYYSP LSSRSLYYVN TKPFMKSEYG ANNVQYQGVQ
310 320 330 340 350
DIFNTESIAK IMSKNGVLFF GLMNNSAIGC WNEHQPLQRE NMDMVAQNEE
360 370 380 390 400
TLQTVVAMKM MHLPQSNKMN RMHRMNRVNR VNRMDRMDRI DRMDRMDRMD
410 420 430 440 450
TMDTMDRIDR MDRMDRIDRI DRMHTMDTMD TMDRTDKMSS MDRMDRMDRV
460 470 480 490 500
DRMDTMDRTD KMSSMDRMDR MDRVDTMDTM DTMDRMDRMD RMDRMDRMDR
510 520 530 540 550
MDTMDRTDKM SRIDRMDKID RMDRMDRTNR MDRMNRMNRQ MNEYMMALSM
560 570 580 590
KLQKFINNDY NFNEVNFRIL GANVNDLIMN TRCANSDNQN NNQNKHNN
Length:598
Mass (Da):70,236
Last modified:May 1, 1999 - v1
Checksum:i2C603C77E7ACDF63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004842 mRNA. Translation: AAD01205.1.
RefSeqiNP_001011599.1. NM_001011599.1.
UniGeneiAme.1691.

Genome annotation databases

GeneIDi406116.
KEGGiame:406116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004842 mRNA. Translation: AAD01205.1.
RefSeqiNP_001011599.1. NM_001011599.1.
UniGeneiAme.1691.

3D structure databases

ProteinModelPortaliO97432.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO97432.
PRIDEiO97432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406116.
KEGGiame:406116.

Organism-specific databases

CTDi406116.

Phylogenomic databases

eggNOGiENOG410KG2T. Eukaryota.
ENOG4110SQU. LUCA.
InParanoidiO97432.
PhylomeDBiO97432.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR017996. Royal_jelly/Protein_yellow.
[Graphical view]
PANTHERiPTHR10009. PTHR10009. 1 hit.
PfamiPF03022. MRJP. 2 hits.
[Graphical view]
PRINTSiPR01366. ROYALJELLY.
ProtoNetiSearch...

Publicationsi

  1. "The family of major royal jelly proteins and its evolution."
    Albert S., Bhattacharya D., Klaudiny J., Schmitzova J., Simuth J.
    J. Mol. Evol. 49:290-297(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Head.

Entry informationi

Entry nameiMRJP5_APIME
AccessioniPrimary (citable) accession number: O97432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.