O97428 (O97428_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ciboulot, isoform A EMBL AAF45919.1

Submitted name:
Ciboulot, isoform B EMBL AAF45920.1
Submitted name:
EG:EG0007.11 protein EMBL CAA21832.1
Submitted name:
RE50273p EMBL AAL90371.1

Gene names

Name:	cib EMBL AAL90371.1 FlyBase FBgn0026084
Synonyms:	EG:EG0007.11 EMBL CAA21832.1
ORF Names:	CG4944 FlyBase FBgn0026084, Dmel_CG4944 EMBL AAF45919.1

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 1SQK PDB 3U8X PDB 3SJH PDB 3U9Z PDB 3U9D Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from mutant phenotype PubMed 10623899PubMed 11030623. Source: FlyBase cytoskeleton organization Inferred from electronic annotation. Source: InterPro larval central nervous system remodeling Inferred from mutant phenotype PubMed 11030623. Source: FlyBase
Cellular_component	cytosol Inferred from direct assay PubMed 14668392. Source: FlyBase
Molecular_function	actin monomer binding Inferred from direct assay PubMed 11030623. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O97428 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 5D68BE289EC8CE2F	FASTA	129	14,410
	10 20 30 40 50 60 MAAPAPALKD LPKVAENLKS QLEGFNQDKL KNASTQEKII LPTAEDVAAE KTQQSIFEGI 70 80 90 100 110 120 TAFNQNNLKH TETNEKNPLP DKEAIEQEKE KNQFIAGIEN FDAKKLKHTE TNEKNVLPTK EVIEAEKQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing the distal X chromosome of Drosophila melanogaster." Ferraz C., Vidal S., Brun C., Bucheton A., Demaille J.G. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Benos P. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL90371.1.
[6]	"The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly." Hertzog M., van Heijenoort C., Didry D., Gaudier M., Coutant J., Gigant B., Didelot G., Preat T., Knossow M., Guittet E., Carlier M.F. Cell 117:611-623(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 10-34.
[7]	"How a single residue in individual ?-thymosin/WH2 domains controls their functions in actin assembly." Didry D., Cantrelle F.X., Husson C., Roblin P., Moorthy A.M., Perez J., Le Clainche C., Hertzog M., Guittet E., Carlier M.F., van Heijenoort C., Renault L. EMBO J. 31:1000-1013(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 8-29.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE014298 Genomic DNA. Translation: AAF45919.1.
AE014298 Genomic DNA. Translation: AAF45920.1.
AY089633 mRNA. Translation: AAL90371.1.
AL033125 Genomic DNA. Translation: CAA21832.1.

RefSeq

NP_001245516.1. NM_001258587.1.
NP_525065.1. NM_080326.4.
NP_726908.1. NM_167001.2.

UniGene

Dm.74.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1SQK	X-ray	2.50	B	10-34	[»]
3SJH	X-ray	1.75	B	8-29	[»]
3U8X	X-ray	2.00	B/D	8-29	[»]
3U9D	X-ray	2.50	B/D	8-24	[»]
3U9Z	X-ray	2.09	C	2-58	[»]

SMR

O97428. Positions 20-52, 56-91, 95-129.

ModBase

Search...

Protein-protein interaction databases

IntAct

O97428. 1 interaction.

MINT

MINT-925149.

STRING

7227.FBpp0070609.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0070639; FBpp0070607; FBgn0026084.
FBtr0070641; FBpp0070609; FBgn0026084.
FBtr0307206; FBpp0298035; FBgn0026084.

GeneID

31359.

KEGG

dme:Dmel_CG4944.

UCSC

CG4944-RA. d. melanogaster.

Organism-specific databases

CTD

31359.

FlyBase

FBgn0026084. cib.

Phylogenomic databases

eggNOG

NOG126035.

GeneTree

ENSGT00530000065074.

InParanoid

O97428.

OMA

KHTETNE.

OrthoDB

EOG4M907R.

Family and domain databases

Gene3D

1.20.5.520. 3 hits.

InterPro

IPR001152. Thymosin_b4.
[Graphical view]

Pfam

PF01290. Thymosin. 3 hits.
[Graphical view]

ProDom

PD005116. Thymosin_b4. 2 hits.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00152. THY. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ABHD14B. drosophila.

EvolutionaryTrace

O97428.

GenomeRNAi

31359.

NextBio

773235.

Entry information

Entry name

O97428_DROME

Accession

Primary (citable) accession number: O97428

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)