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O97397

- CATLL_PHACE

UniProt

O97397 - CATLL_PHACE

Protein

Cathepsin L-like proteinase

Gene
N/A
Organism
Phaedon cochleariae (Mustard beetle)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei134 – 1341By similarity
    Active sitei270 – 2701By similarity
    Active sitei290 – 2901By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Digestion

    Protein family/group databases

    MEROPSiC01.143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin L-like proteinase (EC:3.4.22.-)
    OrganismiPhaedon cochleariae (Mustard beetle)
    Taxonomic identifieri80249 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaChrysomeloideaChrysomelidaeChrysomelinaeChrysomeliniPhaedon

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 324Cathepsin L-like proteinasePRO_0000223700
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – ?Activation peptideSequence AnalysisPRO_0000223699

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi131 ↔ 174By similarity
    Disulfide bondi165 ↔ 206By similarity
    Disulfide bondi263 ↔ 312By similarity

    Keywords - PTMi

    Disulfide bond, Zymogen

    Expressioni

    Tissue specificityi

    Expressed in larval carcasses and gut, and adult gut.1 Publication

    Developmental stagei

    Larvae and adult, but not eggs.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliO97397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O97397-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLIIALAAL IVVINAASDQ ELWADFKKTH ARTYKSLREE KLRFNIFQDT    50
    LRQIAEHNVK YENGESTYYL AINKFSDITD EEFRDMLMKN EASRPNLEGL 100
    EVADLTVGAA PESIDWRSKG VVLPVRNQGE CGSCWALSTA AAIESQSAIK 150
    SGSKVPLSPQ QLVDCSTSYG NHGCNGGFAV NGFEYVKDNG LESDADYPYS 200
    GKEDKCKAND KSRSVVELTG YKKVTASETS LKEAVGTIGP ISAVVFGKPM 250
    KSYGGGIFDD SSCLGDNLHH GVNVVGYGIE NGQKYWIIKN TWGADWGESG 300
    YIRLIRDTDH SCGVEKMASY PILA 324
    Length:324
    Mass (Da):35,468
    Last modified:May 1, 1999 - v1
    Checksum:i5E0F191D2C84067F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17903 mRNA. Translation: CAA76927.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17903 mRNA. Translation: CAA76927.1 .

    3D structure databases

    ProteinModelPortali O97397.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C01.143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNAs encoding a range of digestive enzymes from a phytophagous beetle, Phaedon cochleariae."
      Girard C., Jouanin L.
      Insect Biochem. Mol. Biol. 29:1129-1142(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Larval gut.

    Entry informationi

    Entry nameiCATLL_PHACE
    AccessioniPrimary (citable) accession number: O97397
    Secondary accession number(s): P81520
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3