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O97397 (CATLL_PHACE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin L-like proteinase

EC=3.4.22.-
OrganismPhaedon cochleariae (Mustard beetle)
Taxonomic identifier80249 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaChrysomeloideaChrysomelidaeChrysomelinaeChrysomeliniPhaedon

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed in larval carcasses and gut, and adult gut. Ref.1

Developmental stage

Larvae and adult, but not eggs. Ref.1

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Biological processDigestion
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Zymogen
Gene Ontology (GO)
   Biological_processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – ?Activation peptide PotentialPRO_0000223699
Chain? – 324Cathepsin L-like proteinasePRO_0000223700

Sites

Active site1341 By similarity
Active site2701 By similarity
Active site2901 By similarity

Amino acid modifications

Disulfide bond131 ↔ 174 By similarity
Disulfide bond165 ↔ 206 By similarity
Disulfide bond263 ↔ 312 By similarity

Sequences

Sequence LengthMass (Da)Tools
O97397 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 5E0F191D2C84067F

FASTA32435,468
        10         20         30         40         50         60 
MKLIIALAAL IVVINAASDQ ELWADFKKTH ARTYKSLREE KLRFNIFQDT LRQIAEHNVK 

        70         80         90        100        110        120 
YENGESTYYL AINKFSDITD EEFRDMLMKN EASRPNLEGL EVADLTVGAA PESIDWRSKG 

       130        140        150        160        170        180 
VVLPVRNQGE CGSCWALSTA AAIESQSAIK SGSKVPLSPQ QLVDCSTSYG NHGCNGGFAV 

       190        200        210        220        230        240 
NGFEYVKDNG LESDADYPYS GKEDKCKAND KSRSVVELTG YKKVTASETS LKEAVGTIGP 

       250        260        270        280        290        300 
ISAVVFGKPM KSYGGGIFDD SSCLGDNLHH GVNVVGYGIE NGQKYWIIKN TWGADWGESG 

       310        320 
YIRLIRDTDH SCGVEKMASY PILA 

« Hide

References

[1]"Molecular cloning of cDNAs encoding a range of digestive enzymes from a phytophagous beetle, Phaedon cochleariae."
Girard C., Jouanin L.
Insect Biochem. Mol. Biol. 29:1129-1142(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Larval gut.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17903 mRNA. Translation: CAA76927.1.

3D structure databases

ProteinModelPortalO97397.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC01.143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATLL_PHACE
AccessionPrimary (citable) accession number: O97397
Secondary accession number(s): P81520
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries