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Protein

Mite allergen Eur m 3

Gene

EURM3

Organism
Euroglyphus maynei (Mayne's house dust mite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Charge relay systemBy similarity1
Active sitei114Charge relay systemBy similarity1
Sitei208Required for specificity1
Active sitei214Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.234.

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Eur m 3 (EC:3.4.21.-)
Alternative name(s):
Allergen: Eur m 3
Gene namesi
Name:EURM3
OrganismiEuroglyphus maynei (Mayne's house dust mite)
Taxonomic identifieri6958 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaePyroglyphinaeEuroglyphus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3276. Eur m 3.0101.
343. Eur m 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002814919 – 29By similarityAdd BLAST11
ChainiPRO_000002815030 – 261Mite allergen Eur m 3Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 70PROSITE-ProRule annotation
Disulfide bondi181 ↔ 198PROSITE-ProRule annotation
Disulfide bondi210 ↔ 236PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliO97370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 260Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O97370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVICNAIIVL LLAFNTLANP ILPSSPNATI VGGQKAKAGE CPYQISLQSS
60 70 80 90 100
SHFCGGTILD EYWILTAAHC VNGQTASKLS IRYNSLKHAS GGEKLSVAQI
110 120 130 140 150
YQHEKYDSWT IDNDIALIKL QSPMTLDQKN AKSVQLPSQG SDVKVGDKVR
160 170 180 190 200
VSGWGYLKEG SYSLPSDMYR VDIDIVAREQ CNKLYEEAGA TITDNMICGG
210 220 230 240 250
NVADGGVDSC QGDSGGPVVD VASNQIVGIV SWGYGCARKG YPGVYTRVGS
260
FIDWIDSKRS Q
Length:261
Mass (Da):28,038
Last modified:May 1, 1999 - v1
Checksum:i6B53BFE63B3850BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047615 mRNA. Translation: AAD10712.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047615 mRNA. Translation: AAD10712.1.

3D structure databases

ProteinModelPortaliO97370.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3276. Eur m 3.0101.
343. Eur m 3.
MEROPSiS01.234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEURM3_EURMA
AccessioniPrimary (citable) accession number: O97370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.