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Protein
Submitted name:

BM-40

Gene

SPARC

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • anterior Malpighian tubule development Source: FlyBase
  • basement membrane assembly Source: FlyBase
  • cell adhesion Source: FlyBase
  • extracellular matrix constituent secretion Source: FlyBase
  • larval fat body development Source: FlyBase
  • larval feeding behavior Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • mesoderm development Source: FlyBase
  • signal transduction Source: InterPro
  • trachea development Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-3000178. ECM proteoglycans.
R-DME-3000497. Scavenging by Class H Receptors.
R-DME-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-DME-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Submitted name:
BM-40Imported
Submitted name:
MIP10412p1Imported
Submitted name:
Secreted protein, acidic, cysteine-rich, isoform AImported
Submitted name:
Secreted protein, acidic, cysteine-rich, isoform BImported
Gene namesi
Name:SPARCImported
Synonyms:BM-40-SPARCImported, BM-40-SPARC-RAImported, BM-40/SPARCImported
ORF Names:CG6378Imported, Dmel_CG6378Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0026562. SPARC.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: InterPro
  • proteinaceous extracellular matrix Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501068019721 – 304Sequence analysisAdd BLAST284

Expressioni

Gene expression databases

BgeeiFBgn0026562.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-306801.
STRINGi7227.FBpp0084464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 280SPARC_Ca_bdgInterPro annotationAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 68Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4004. Eukaryota.
ENOG41101WW. LUCA.
GeneTreeiENSGT00510000046787.
OMAiKDFPRRM.
OrthoDBiEOG091G0FR6.

Family and domain databases

CDDicd00252. SPARC_EC. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR001999. Osteonectin_CS.
IPR019577. SPARC/Testican_Ca-bd-dom.
PfamiView protein in Pfam
PF10591. SPARC_Ca_bdg. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS00613. OSTEONECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O97365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLWLLLGL GLLAVSHVQA STEFSEDLLD EDLDLSDIDE NEEEFLRLLE
60 70 80 90 100
EKNKIKDIER ENEIATKLAE VQHNLLNPVV EVDLCETMSC GAGRICQMHD
110 120 130 140 150
EKPKCVCIPE CPEEVDTRRL VCTNTNETWP SDCSVYQQRC WCDSGEPGCT
160 170 180 190 200
NPDNAHMHID YYGACHEPRS CEGEDLKDFP RRMRDWLFNV MRDLAERDEL
210 220 230 240 250
TEHYMQMELE AETNNSRRWS NAAVWKWCDL DGDTDRSVSR HELFPIRAPL
260 270 280 290 300
VSLEHCIAPF LESCDSNKDH RITLVEWGAC LELDPEDLKE RCDDVQRAQP

HLLG
Length:304
Mass (Da):35,182
Last modified:May 1, 1999 - v1
Checksum:iD4ED66EBFAAF3778
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56632.2.
BT128781 mRNA. Translation: AEK87153.1.
AE014297 Genomic DNA. Translation: AGB96378.1.
AJ133736 mRNA. Translation: CAB39319.1.
RefSeqiNP_001262998.1. NM_001276069.1.
NP_651509.2. NM_143252.4.
UniGeneiDm.1347.

Genome annotation databases

EnsemblMetazoaiFBtr0085094; FBpp0084464; FBgn0026562.
FBtr0334309; FBpp0306424; FBgn0026562.
GeneIDi43230.
KEGGidme:Dmel_CG6378.
UCSCiCG6378-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiO97365_DROME
AccessioniPrimary (citable) accession number: O97365
Secondary accession number(s): Q9VBB0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported