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Protein
Submitted name:

BM-40

Gene

SPARC

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • anterior Malpighian tubule development Source: FlyBase
  • basement membrane assembly Source: FlyBase
  • cell adhesion Source: FlyBase
  • extracellular matrix constituent secretion Source: FlyBase
  • larval fat body development Source: FlyBase
  • larval feeding behavior Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • mesoderm development Source: FlyBase
  • signal transduction Source: InterPro
  • trachea development Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-114608 Platelet degranulation
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Submitted name:
BM-40Imported
Submitted name:
MIP10412p1Imported
Submitted name:
Secreted protein, acidic, cysteine-rich, isoform AImported
Submitted name:
Secreted protein, acidic, cysteine-rich, isoform BImported
Gene namesi
Name:SPARCImported
Synonyms:anon-EST:Posey291Imported, BM-40Imported, BM-40 SparcImported, BM-40-SPARCImported, BM-40-SPARC-RAImported, BM-40/SPARCImported, BM40Imported, CT19876Imported, Dmel\CG6378Imported, dSPARCImported, dSparcImported, dsparcImported, SparcImported, sparcImported
ORF Names:CG6378Imported, Dmel_CG6378Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0026562 SPARC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501353025421 – 304Sequence analysisAdd BLAST284

Proteomic databases

PRIDEiO97365

Expressioni

Gene expression databases

BgeeiFBgn0026562
ExpressionAtlasiO97365 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiO97365, 4 interactors
STRINGi7227.FBpp0084464

Structurei

3D structure databases

SMRiO97365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 280SPARC_Ca_bdgInterPro annotationAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 68Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4004 Eukaryota
ENOG41101WW LUCA
GeneTreeiENSGT00510000046787
OMAiKDFPRRM
OrthoDBiEOG091G0FR6

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR001999 Osteonectin_CS
IPR037641 SPARC
IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERiPTHR13866 PTHR13866, 1 hit
PfamiView protein in Pfam
PF10591 SPARC_Ca_bdg, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS00613 OSTEONECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

O97365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLWLLLGL GLLAVSHVQA STEFSEDLLD EDLDLSDIDE NEEEFLRLLE
60 70 80 90 100
EKNKIKDIER ENEIATKLAE VQHNLLNPVV EVDLCETMSC GAGRICQMHD
110 120 130 140 150
EKPKCVCIPE CPEEVDTRRL VCTNTNETWP SDCSVYQQRC WCDSGEPGCT
160 170 180 190 200
NPDNAHMHID YYGACHEPRS CEGEDLKDFP RRMRDWLFNV MRDLAERDEL
210 220 230 240 250
TEHYMQMELE AETNNSRRWS NAAVWKWCDL DGDTDRSVSR HELFPIRAPL
260 270 280 290 300
VSLEHCIAPF LESCDSNKDH RITLVEWGAC LELDPEDLKE RCDDVQRAQP

HLLG
Length:304
Mass (Da):35,182
Last modified:May 1, 1999 - v1
Checksum:iD4ED66EBFAAF3778
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56632.2
BT128781 mRNA Translation: AEK87153.1
AE014297 Genomic DNA Translation: AGB96378.1
AJ133736 mRNA Translation: CAB39319.1
RefSeqiNP_001262998.1, NM_001276069.1
NP_651509.2, NM_143252.4
UniGeneiDm.1347

Genome annotation databases

EnsemblMetazoaiFBtr0085094; FBpp0084464; FBgn0026562
FBtr0334309; FBpp0306424; FBgn0026562
GeneIDi43230
KEGGidme:Dmel_CG6378
UCSCiCG6378-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiO97365_DROME
AccessioniPrimary (citable) accession number: O97365
Secondary accession number(s): Q9VBB0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health