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Protein
Submitted name:

BM-40

Gene

SPARC

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • anterior Malpighian tubule development Source: FlyBase
  • basement membrane assembly Source: FlyBase
  • cell adhesion Source: FlyBase
  • extracellular matrix constituent secretion Source: FlyBase
  • larval fat body development Source: FlyBase
  • larval feeding behavior Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • mesoderm development Source: FlyBase
  • signal transduction Source: InterPro
  • trachea development Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-3000497. Scavenging by Class H Receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
BM-40Imported
Submitted name:
MIP10412p1Imported
Submitted name:
Secreted protein, acidic, cysteine-rich, isoform AImported
Submitted name:
Secreted protein, acidic, cysteine-rich, isoform BImported
Gene namesi
Name:SPARCImported
Synonyms:BM-40-SPARCImported, BM-40-SPARC-RAImported, BM-40/SPARCImported
ORF Names:CG6378Imported, Dmel_CG6378Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0026562. SPARC.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: FlyBase
  • extracellular space Source: InterPro
  • proteinaceous extracellular matrix Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 304284Sequence analysisPRO_5007697269Add
BLAST

Expressioni

Gene expression databases

BgeeiFBgn0026562.

Interactioni

Protein-protein interaction databases

MINTiMINT-306801.
STRINGi7227.FBpp0084464.

Structurei

3D structure databases

SMRiO97365. Positions 85-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 280112SPARC_Ca_bdgInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 6828Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4004. Eukaryota.
ENOG41101WW. LUCA.
GeneTreeiENSGT00510000046787.
OMAiKDFPRRM.
OrthoDBiEOG091G0FR6.
PhylomeDBiO97365.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR001999. Osteonectin_CS.
IPR019577. SPARC/Testican_Ca-bd-dom.
[Graphical view]
PfamiPF10591. SPARC_Ca_bdg. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS00613. OSTEONECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLWLLLGL GLLAVSHVQA STEFSEDLLD EDLDLSDIDE NEEEFLRLLE
60 70 80 90 100
EKNKIKDIER ENEIATKLAE VQHNLLNPVV EVDLCETMSC GAGRICQMHD
110 120 130 140 150
EKPKCVCIPE CPEEVDTRRL VCTNTNETWP SDCSVYQQRC WCDSGEPGCT
160 170 180 190 200
NPDNAHMHID YYGACHEPRS CEGEDLKDFP RRMRDWLFNV MRDLAERDEL
210 220 230 240 250
TEHYMQMELE AETNNSRRWS NAAVWKWCDL DGDTDRSVSR HELFPIRAPL
260 270 280 290 300
VSLEHCIAPF LESCDSNKDH RITLVEWGAC LELDPEDLKE RCDDVQRAQP

HLLG
Length:304
Mass (Da):35,182
Last modified:May 1, 1999 - v1
Checksum:iD4ED66EBFAAF3778
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56632.2.
BT128781 mRNA. Translation: AEK87153.1.
AE014297 Genomic DNA. Translation: AGB96378.1.
AJ133736 mRNA. Translation: CAB39319.1.
RefSeqiNP_001262998.1. NM_001276069.1.
NP_651509.2. NM_143252.4.
UniGeneiDm.1347.

Genome annotation databases

EnsemblMetazoaiFBtr0085094; FBpp0084464; FBgn0026562.
FBtr0334309; FBpp0306424; FBgn0026562.
GeneIDi43230.
KEGGidme:Dmel_CG6378.
UCSCiCG6378-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56632.2.
BT128781 mRNA. Translation: AEK87153.1.
AE014297 Genomic DNA. Translation: AGB96378.1.
AJ133736 mRNA. Translation: CAB39319.1.
RefSeqiNP_001262998.1. NM_001276069.1.
NP_651509.2. NM_143252.4.
UniGeneiDm.1347.

3D structure databases

SMRiO97365. Positions 85-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-306801.
STRINGi7227.FBpp0084464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085094; FBpp0084464; FBgn0026562.
FBtr0334309; FBpp0306424; FBgn0026562.
GeneIDi43230.
KEGGidme:Dmel_CG6378.
UCSCiCG6378-RA. d. melanogaster.

Organism-specific databases

CTDi6678.
FlyBaseiFBgn0026562. SPARC.

Phylogenomic databases

eggNOGiKOG4004. Eukaryota.
ENOG41101WW. LUCA.
GeneTreeiENSGT00510000046787.
OMAiKDFPRRM.
OrthoDBiEOG091G0FR6.
PhylomeDBiO97365.

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-3000497. Scavenging by Class H Receptors.

Miscellaneous databases

ChiTaRSiBM-40-SPARC. fly.
GenomeRNAii43230.

Gene expression databases

BgeeiFBgn0026562.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR001999. Osteonectin_CS.
IPR019577. SPARC/Testican_Ca-bd-dom.
[Graphical view]
PfamiPF10591. SPARC_Ca_bdg. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS00613. OSTEONECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO97365_DROME
AccessioniPrimary (citable) accession number: O97365
Secondary accession number(s): Q9VBB0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.