O97252 (O97252_PLAF7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit RuleBase RU003567

Gene names

ORF Names:

PFC0310c EMBL CAB39018.1

Organism

Plasmodium falciparum (isolate 3D7)

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase S14 family. RuleBase RU003567

Ontologies

Keywords
Molecular function	Hydrolase Protease EMBL CAB39018.1
Technical term	3D-structure PDB 2F6I Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O97252 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3DE959328D14CE87	FASTA	370	43,321
	10 20 30 40 50 60 MIYLFLFLFL ILLKNKKIQT KKSIKNSNIL TFIPLSKKNE IVKENIGKLL TYNLQYDQGY 70 80 90 100 110 120 TNYNKKVRKI NVHNSSSEFA NNINLDIEKQ NNERAILKKE DLNFQIKNDC ISKDNINKKK 130 140 150 160 170 180 IKNMHNKDQG MIQHTNTNDN IDYTNSNYNN YLNYDVKKKK NKKRKYSKVQ QQIITNNDDI 190 200 210 220 230 240 KDMKKDVKLF FFKKRIIYLT DEINKKTADE LISQLLYLDN INHNDIKIYI NSPGGSINEG 250 260 270 280 290 300 LAILDIFNYI KSDIQTISFG LVASMASVIL ASGKKGKRKS LPNCRIMIHQ PLGNAFGHPQ 310 320 330 340 350 360 DIEIQTKEIL YLKKLLYHYL SSFTNQTVET IEKDSDRDYY MNALEAKQYG IIDEVIETKL 370 PHPYFNKVEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed: 12368864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[2]	"Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13." Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z. , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G. Nature 419:527-531(2002) [PubMed: 12368867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[3]	"The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum." Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M., Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R., Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K. , Jassal B., Kyes S., McLean J., Moule S., Mungall K.L., Murphy L., Oliver K., Quail M.A., Rajandream M.A., Rutter S., Skelton J., Squares R., Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C., Barrell B.G. Nature 400:532-538(1999) [PubMed: 10448855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[4]	"Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms." Vedadi M., Lew J., Artz J., Amani M., Zhao Y., Dong A., Wasney G.A., Gao M., Hills T., Brokx S., Qiu W., Sharma S., Diassiti A., Alam Z., Melone M., Mulichak A., Wernimont A., Bray J. , Loppnau P., Plotnikova O., Newberry K., Sundararajan E., Houston S., Walker J., Tempel W., Bochkarev A., Kozieradzki I., Edwards A., Arrowsmith C., Roos D., Kain K., Hui R. Mol. Biochem. Parasitol. 151:100-110(2007) [PubMed: 17125854] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 179-370.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL844502 Genomic DNA. Translation: CAB39018.1.

RefSeq

XP_001351149.1. XM_001351113.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2F6I	X-ray	2.45	A/B/C/D/E/F/G	179-370	[»]

ProteinModelPortal

O97252.

SMR

O97252. Positions 179-365.

ModBase

Search...

Protein family/group databases

MEROPS

S14.011.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

PFC0310c:mRNA; PFC0310c:pep; PFC0310c.

GeneID

814391.

KEGG

pfa:PFC0310c.

NMPDR

fig|36329.1.peg.70.

Organism-specific databases

EuPathDB

EupathDB:PFC0310c.

Phylogenomic databases

GeneTree

EPrGT00050000003218.

HOGENOM

HBG558421.

ProtClustDB

CLSZ2500462.

Family and domain databases

HAMAP

MF_00444. ClpP.
[Tree]

InterPro

IPR023562. Pept_S14/S49.
IPR001907. Pept_S14_ClpP.
IPR018215. Pept_S14_ClpP_AS.
[Graphical view]

KO

K01358.

PANTHER

PTHR10381. Pept_S14_ClpP. 1 hit.

Pfam

PF00574. CLP_protease. 1 hit.
[Graphical view]

PRINTS

PR00127. CLPPROTEASEP.

PROSITE

PS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O97252_PLAF7

Accession

Primary (citable) accession number: O97252

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)