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O97192

- TPM_HELAS

UniProt

O97192 - TPM_HELAS

Protein

Tropomyosin

Gene
N/A
Organism
Helix aspersa (Brown garden snail) (Cornu aspersum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin
    Alternative name(s):
    Allergen: Hel as 1
    OrganismiHelix aspersa (Brown garden snail) (Cornu aspersum)
    Taxonomic identifieri6535 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataEupulmonataStylommatophoraSigmurethraHelicoideaHelicidaeHelix

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3309. Hel as 1.0101.
    378. Hel as 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284TropomyosinPRO_0000205667Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO97192.
    SMRiO97192. Positions 1-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284By similarityAdd
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    Sequence similaritiesi

    Belongs to the tropomyosin family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.

    Sequencei

    Sequence statusi: Complete.

    O97192-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAIKKKMLA MKMEKENALD RAEQVEQKLR DCECNKNKVE EDLNNLQKKF    50
    AILENDFDSI NEQLLDANTK LEASEKKNAE IESETAGLQR RIQLLEEDLE 100
    RSEERLQSAT EKLEEASKAA DESERGRKVL ESRSLADDER LDGLEAQLKE 150
    AKYIAEDAER KFDEAARKLA ITEVDLERAE ARLEAAEAKI LELEEELKVV 200
    GNNMKSLEIS EQEASQREDS YEETIRDLTQ RLKDAENRAS EAERTVSKLQ 250
    KEVDRLEDEL LAEKERYKAT SDELDSTFAE LAGY 284
    Length:284
    Mass (Da):32,637
    Last modified:May 1, 1999 - v1
    Checksum:i01B87021E0F32D4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14855 mRNA. Translation: CAB38044.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14855 mRNA. Translation: CAB38044.1 .

    3D structure databases

    ProteinModelPortali O97192.
    SMRi O97192. Positions 1-282.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3309. Hel as 1.0101.
    378. Hel as 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, isolation, and IgE-binding properties of Helix aspersa (brown garden snail) tropomyosin."
      Asturias J.A., Eraso E., Arilla M.C., Gomez-Bayon N., Inacio F., Martinez A.
      Int. Arch. Allergy Immunol. 128:90-96(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTPM_HELAS
    AccessioniPrimary (citable) accession number: O97192
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3