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O97192

- TPM_HELAS

UniProt

O97192 - TPM_HELAS

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Protein
Tropomyosin
Gene
N/A
Organism
Helix aspersa (Brown garden snail) (Cornu aspersum)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Allergen: Hel as 1
OrganismiHelix aspersa (Brown garden snail) (Cornu aspersum)
Taxonomic identifieri6535 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataEupulmonataStylommatophoraSigmurethraHelicoideaHelicidaeHelix

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3309. Hel as 1.0101.
378. Hel as 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Tropomyosin
PRO_0000205667Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliO97192.
SMRiO97192. Positions 1-282.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284 By similarity
Add
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.

Sequencei

Sequence statusi: Complete.

O97192-1 [UniParc]FASTAAdd to Basket

« Hide

MDAIKKKMLA MKMEKENALD RAEQVEQKLR DCECNKNKVE EDLNNLQKKF    50
AILENDFDSI NEQLLDANTK LEASEKKNAE IESETAGLQR RIQLLEEDLE 100
RSEERLQSAT EKLEEASKAA DESERGRKVL ESRSLADDER LDGLEAQLKE 150
AKYIAEDAER KFDEAARKLA ITEVDLERAE ARLEAAEAKI LELEEELKVV 200
GNNMKSLEIS EQEASQREDS YEETIRDLTQ RLKDAENRAS EAERTVSKLQ 250
KEVDRLEDEL LAEKERYKAT SDELDSTFAE LAGY 284
Length:284
Mass (Da):32,637
Last modified:May 1, 1999 - v1
Checksum:i01B87021E0F32D4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14855 mRNA. Translation: CAB38044.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14855 mRNA. Translation: CAB38044.1 .

3D structure databases

ProteinModelPortali O97192.
SMRi O97192. Positions 1-282.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3309. Hel as 1.0101.
378. Hel as 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000533. Tropomyosin.
[Graphical view ]
Pfami PF00261. Tropomyosin. 1 hit.
[Graphical view ]
PRINTSi PR00194. TROPOMYOSIN.
ProtoNeti Search...

Publicationsi

  1. "Cloning, isolation, and IgE-binding properties of Helix aspersa (brown garden snail) tropomyosin."
    Asturias J.A., Eraso E., Arilla M.C., Gomez-Bayon N., Inacio F., Martinez A.
    Int. Arch. Allergy Immunol. 128:90-96(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTPM_HELAS
AccessioniPrimary (citable) accession number: O97192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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