O97192 (TPM_HELAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin Alternative name(s): Allergen=Hel as 1
Organism	Helix aspersa (Brown garden snail)
Taxonomic identifier	6535 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Panpulmonata › Eupulmonata › Stylommatophora › Sigmurethra › Helicoidea › Helicidae › Helix

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subunit structure	Homodimer By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Disease	Allergen
Domain	Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin		PRO_0000205667
Regions
	Coiled coil	1 – 284	284	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O97192 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 01B87021E0F32D4D	FASTA	284	32,637
	10 20 30 40 50 60 MDAIKKKMLA MKMEKENALD RAEQVEQKLR DCECNKNKVE EDLNNLQKKF AILENDFDSI 70 80 90 100 110 120 NEQLLDANTK LEASEKKNAE IESETAGLQR RIQLLEEDLE RSEERLQSAT EKLEEASKAA 130 140 150 160 170 180 DESERGRKVL ESRSLADDER LDGLEAQLKE AKYIAEDAER KFDEAARKLA ITEVDLERAE 190 200 210 220 230 240 ARLEAAEAKI LELEEELKVV GNNMKSLEIS EQEASQREDS YEETIRDLTQ RLKDAENRAS 250 260 270 280 EAERTVSKLQ KEVDRLEDEL LAEKERYKAT SDELDSTFAE LAGY

References

[1]	"Cloning, isolation, and IgE-binding properties of Helix aspersa (brown garden snail) tropomyosin." Asturias J.A., Eraso E., Arilla M.C., Gomez-Bayon N., Inacio F., Martinez A. Int. Arch. Allergy Immunol. 128:90-96(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14855 mRNA. Translation: CAB38044.1.
3D structure databases
ProteinModelPortal	O97192.
SMR	O97192. Positions 1-282.
ModBase	Search...
Protein family/group databases
Allergome	3309. Hel as 1.0101. 378. Hel as 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_HELAS

Accession

Primary (citable) accession number: O97192

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	May 1, 1999
Last modified:	October 3, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)