Reviewed, UniProtKB/Swiss-Prot O97178 (ESMA_DROME)

Names and origin

Protein names

Recommended name:
    Enhancer of split malpha protein
      Short name=E(spl)malpha

Gene names

Name:	malpha
ORF Names:	CG8337

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Part of the Notch signaling pathway.
Developmental stage	Mesectodermal expression appears shortly before the onset of gastrulation. Later it is detected in the neuro-ectoderm as well as in the mesoderm in a highly dynamic pattern in many stages of embryogenesis. In imaginal disks, expressed as following: in the eye disk, within and posterior to the morphogenetic furrow; in the wing pouch, in the presumptive intervein regions and wing margin; in the leg disk, general expression.
Sequence similarities	Belongs to the M4-like protein family.

Ontologies

Keywords
Biological process	Notch signaling pathway
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Notch signaling pathway Ref.2 Inferred from mutant phenotype. Source: FlyBase cell fate specification Ref.2 Inferred from mutant phenotype. Source: FlyBase sensory organ development Ref.2 Inferred from mutant phenotype. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Enhancer of split malpha protein		PRO_0000087061
Regions
	Compositional bias	5 – 8	4	Poly-Val

Sequences

	Sequence		Length	Mass (Da)
	O97178-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B277BCC25CD82F59	FASTA	138	15,876
	10 20 30 40 50 60 MCQQVVVVAN TNNKMKTSYS IKQVLKTLFK KQQKQQQKPQ GSLESLESVD NLRNAQVEEA 70 80 90 100 110 120 YYAEIDENAA NEKLAQLAHS QEFEIVEEQE DEEDVYVPVR FARTTAGTFF WTTNLQPVAS 130 VEPAMCYSMQ FQDRWAQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes." Wurmbach E., Wech I., Preiss A. Mech. Dev. 80:171-180(1999) [PubMed: 10072784] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Embryo.
[2]	"Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes." Lai E.C., Bodner R., Kavaler J., Freschi G., Posakony J.W. Development 127:291-306(2000) [PubMed: 10603347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Embryo.
[3]	"Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila." Macdonald S.J., Long A.D. Mol. Biol. Evol. 22:607-619(2005) [PubMed: 15537803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[6]	Stapleton M., Booth B., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
[7]	"A low-cost open-source SNP genotyping platform for association mapping applications." Macdonald S.J., Pastinen T., Genissel A., Cornforth T.W., Long A.D. Genome Biol. 6:RESEARCH105.1-RESEARCH105.11(2005) [PubMed: 16356268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-138. Strain: Nv2001_m0470, Nv2001_m0471, Nv2001_m0472, Nv2001_m0473, Nv2001_m0474, Nv2001_m0475, Nv2001_m0476, Nv2001_m0477, Nv2001_m0478, Nv2001_m0479, Nv2001_m0480, Nv2001_m0481, Nv2001_m0482, Nv2001_m0483, Nv2001_m0484, Nv2001_m0485, Nv2001_m0486, Nv2001_m0488, Nv2001_m0489, Nv2001_m0490, Nv2001_m0491, Nv2001_m0492, Nv2001_m0493, Nv2001_m0494, Nv2001_m0495, Nv2001_m0496, Nv2001_m0498, Nv2001_m0499, Nv2001_m0500, Nv2001_m0501, Nv2001_m0502, Nv2001_m0503, Nv2001_m0504, Nv2001_m0506, Nv2001_m0507, Nv2001_m0508, Nv2001_m0509, Nv2001_m0510, Nv2001_m0511, Nv2001_m0512, Nv2001_m0513, Nv2001_m0514, Nv2001_m0515, Nv2001_m0516, Nv2001_m0517, Nv2001_m0518, Nv2001_m0519, Nv2001_m0520, Nv2001_m0521, Nv2001_m0522, Nv2001_m0523, Nv2001_m0524, Nv2001_m0526, Nv2001_m0527, Nv2001_m0528, Nv2001_m0530, Nv2001_m0531, Nv2001_m0532, Nv2001_m0533, Nv2001_m0534, Nv2001_m0535, Nv2001_m0536, Nv2001_m0537, Nv2001_m0538, Nv2001_m0539, Nv2001_m0540, Nv2001_m0541, Nv2001_m0542, Nv2001_m0543, Nv2001_m0544, Nv2001_m0545, Nv2001_m0546, Nv2001_m0547, Nv2001_m0549, Nv2001_m0550, Nv2001_m0551, Nv2001_m0552, Nv2001_m0553, Nv2001_m0554, Nv2001_m0555, Nv2001_m0556, Nv2001_m0557, Nv2001_m0558, Nv2001_m0559, Nv2001_m0560, Nv2001_m0561, Nv2001_m0562 and Nv2001_m0563.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ011140 Genomic DNA. Translation: CAB39164.1. AF115456 Genomic DNA. Translation: AAF12878.1. AY779906 Genomic DNA. Translation: AAV59052.1. AY779907 Genomic DNA. Translation: AAV59064.1. AY779908 Genomic DNA. Translation: AAV59076.1. AY779909 Genomic DNA. Translation: AAV59088.1. AY779910 Genomic DNA. Translation: AAV59100.1. AY779911 Genomic DNA. Translation: AAV59112.1. AY779912 Genomic DNA. Translation: AAV59124.1. AY779913 Genomic DNA. Translation: AAV59136.1. AY779914 Genomic DNA. Translation: AAV59148.1. AY779915 Genomic DNA. Translation: AAV59160.1. AY779916 Genomic DNA. Translation: AAV59172.1. AY779917 Genomic DNA. Translation: AAV59184.1. AY779918 Genomic DNA. Translation: AAV59196.1. AY779919 Genomic DNA. Translation: AAV59208.1. AY779920 Genomic DNA. Translation: AAV59220.1. AY779921 Genomic DNA. Translation: AAV59232.1. AE014297 Genomic DNA. Translation: AAF56547.1. BT030909 mRNA. Translation: ABV82291.1. BT030931 mRNA. Translation: ABV82313.1. BT030967 mRNA. Translation: ABV82349.1. AY905812 Genomic DNA. Translation: AAX60158.1. AY905813 Genomic DNA. Translation: AAX60159.1. AY905814 Genomic DNA. Translation: AAX60160.1. AY905815 Genomic DNA. Translation: AAX60161.1. AY905816 Genomic DNA. Translation: AAX60162.1. AY905817 Genomic DNA. Translation: AAX60163.1. AY905818 Genomic DNA. Translation: AAX60164.1. AY905819 Genomic DNA. Translation: AAX60165.1. AY905820 Genomic DNA. Translation: AAX60166.1. AY905821 Genomic DNA. Translation: AAX60167.1. AY905822 Genomic DNA. Translation: AAX60168.1. AY905823 Genomic DNA. Translation: AAX60169.1. AY905824 Genomic DNA. Translation: AAX60170.1. AY905825 Genomic DNA. Translation: AAX60171.1. AY905826 Genomic DNA. Translation: AAX60172.1. AY905827 Genomic DNA. Translation: AAX60173.1. AY905828 Genomic DNA. Translation: AAX60174.1. AY905829 Genomic DNA. Translation: AAX60175.1. AY905830 Genomic DNA. Translation: AAX60176.1. AY905831 Genomic DNA. Translation: AAX60177.1. AY905832 Genomic DNA. Translation: AAX60178.1. AY905833 Genomic DNA. Translation: AAX60179.1. AY905834 Genomic DNA. Translation: AAX60180.1. AY905835 Genomic DNA. Translation: AAX60181.1. AY905836 Genomic DNA. Translation: AAX60182.1. AY905837 Genomic DNA. Translation: AAX60183.1. AY905838 Genomic DNA. Translation: AAX60184.1. AY905839 Genomic DNA. Translation: AAX60185.1. AY905840 Genomic DNA. Translation: AAX60186.1. AY905841 Genomic DNA. Translation: AAX60187.1. AY905842 Genomic DNA. Translation: AAX60188.1. AY905843 Genomic DNA. Translation: AAX60189.1. AY905844 Genomic DNA. Translation: AAX60190.1. AY905845 Genomic DNA. Translation: AAX60191.1. AY905846 Genomic DNA. Translation: AAX60192.1. AY905847 Genomic DNA. Translation: AAX60193.1. AY905848 Genomic DNA. Translation: AAX60194.1. AY905849 Genomic DNA. Translation: AAX60195.1. AY905850 Genomic DNA. Translation: AAX60196.1. AY905851 Genomic DNA. Translation: AAX60197.1. AY905852 Genomic DNA. Translation: AAX60198.1. AY905853 Genomic DNA. Translation: AAX60199.1. AY905854 Genomic DNA. Translation: AAX60200.1. AY905855 Genomic DNA. Translation: AAX60201.1. AY905856 Genomic DNA. Translation: AAX60202.1. AY905857 Genomic DNA. Translation: AAX60203.1. AY905858 Genomic DNA. Translation: AAX60204.1. AY905859 Genomic DNA. Translation: AAX60205.1. AY905860 Genomic DNA. Translation: AAX60206.1. AY905861 Genomic DNA. Translation: AAX60207.1. AY905862 Genomic DNA. Translation: AAX60208.1. AY905863 Genomic DNA. Translation: AAX60209.1. AY905864 Genomic DNA. Translation: AAX60210.1. AY905865 Genomic DNA. Translation: AAX60211.1. AY905866 Genomic DNA. Translation: AAX60212.1. AY905867 Genomic DNA. Translation: AAX60213.1. AY905868 Genomic DNA. Translation: AAX60214.1. AY905869 Genomic DNA. Translation: AAX60215.1. AY905870 Genomic DNA. Translation: AAX60216.1. AY905871 Genomic DNA. Translation: AAX60217.1. AY905872 Genomic DNA. Translation: AAX60218.1. AY905873 Genomic DNA. Translation: AAX60219.1. AY905874 Genomic DNA. Translation: AAX60220.1. AY905875 Genomic DNA. Translation: AAX60221.1. AY905876 Genomic DNA. Translation: AAX60222.1. AY905877 Genomic DNA. Translation: AAX60223.1. AY905878 Genomic DNA. Translation: AAX60224.1. AY905879 Genomic DNA. Translation: AAX60225.1. AY905880 Genomic DNA. Translation: AAX60226.1. AY905881 Genomic DNA. Translation: AAX60227.1. AY905882 Genomic DNA. Translation: AAX60228.1. AY905883 Genomic DNA. Translation: AAX60229.1. AY905884 Genomic DNA. Translation: AAX60230.1. AY905885 Genomic DNA. Translation: AAX60231.1. AY905886 Genomic DNA. Translation: AAX60232.1. AY905887 Genomic DNA. Translation: AAX60233.1. AY905888 Genomic DNA. Translation: AAX60234.1. AY905889 Genomic DNA. Translation: AAX60235.1. AY905890 Genomic DNA. Translation: AAX60236.1. AY905891 Genomic DNA. Translation: AAX60237.1. AY905892 Genomic DNA. Translation: AAX60238.1. AY905893 Genomic DNA. Translation: AAX60239.1. AY905894 Genomic DNA. Translation: AAX60240.1. AY905895 Genomic DNA. Translation: AAX60241.1. AY905896 Genomic DNA. Translation: AAX60242.1. AY905897 Genomic DNA. Translation: AAX60243.1. AY905898 Genomic DNA. Translation: AAX60244.1. AY905899 Genomic DNA. Translation: AAX60245.1.
RefSeq	NP_524506.1.
UniGene	Dm.24098
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O97178.
Genome annotation databases
Ensembl	FBgn0002732. Drosophila melanogaster. [Contig view]
GeneID	43153.
KEGG	dme:Dmel_CG8337.
NMPDR	fig|7227.3.peg.14762.
Organism-specific databases
FlyBase	FBgn0002732. malpha.
Phylogenomic databases
HOGENOM	O97178.
OMA	O97178. IDENAAN.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-013498-MON.
Gene expression databases
ArrayExpress	O97178.
GermOnline	CG8337. Drosophila melanogaster.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	832442.

Entry information

Entry name

ESMA_DROME

Accession

Primary (citable) accession number: O97178
Secondary accession number(s): A8E6W7 , Q56MK8, Q56MK9, Q56ML2, Q56ML4, Q56MM3, Q56MM6, Q56MN5, Q56MP7, Q56MQ1, Q56MQ4, Q56MT0, Q5S4K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project