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O97178 (ESMA_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enhancer of split malpha protein
Short name=E(spl)malpha
Gene names
Name:malpha
ORF Names:CG8337
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the Notch signaling pathway.

Developmental stage

Mesectodermal expression appears shortly before the onset of gastrulation. Later it is detected in the neuro-ectoderm as well as in the mesoderm in a highly dynamic pattern in many stages of embryogenesis. In imaginal disks, expressed as following: in the eye disk, within and posterior to the morphogenetic furrow; in the wing pouch, in the presumptive intervein regions and wing margin; in the leg disk, general expression.

Sequence similarities

Belongs to the M4-like protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Enhancer of split malpha protein
PRO_0000087061

Regions

Compositional bias5 – 84Poly-Val

Sequences

Sequence LengthMass (Da)Tools
O97178 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B277BCC25CD82F59

FASTA13815,876
        10         20         30         40         50         60 
MCQQVVVVAN TNNKMKTSYS IKQVLKTLFK KQQKQQQKPQ GSLESLESVD NLRNAQVEEA 

        70         80         90        100        110        120 
YYAEIDENAA NEKLAQLAHS QEFEIVEEQE DEEDVYVPVR FARTTAGTFF WTTNLQPVAS 

       130 
VEPAMCYSMQ FQDRWAQA

« Hide

References

« Hide 'large scale' references
[1]"The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes."
Wurmbach E., Wech I., Preiss A.
Mech. Dev. 80:171-180(1999) [PubMed: 10072784] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Embryo.
[2]"Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes."
Lai E.C., Bodner R., Kavaler J., Freschi G., Posakony J.W.
Development 127:291-306(2000) [PubMed: 10603347] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Embryo.
[3]"Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila."
Macdonald S.J., Long A.D.
Mol. Biol. Evol. 22:607-619(2005) [PubMed: 15537803] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
[4]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[5]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[6]Stapleton M., Booth B., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
[7]"A low-cost open-source SNP genotyping platform for association mapping applications."
Macdonald S.J., Pastinen T., Genissel A., Cornforth T.W., Long A.D.
Genome Biol. 6:R105.1-R105.11(2005) [PubMed: 16356268] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-138.
Strain: Nv2001_m0470, Nv2001_m0471, Nv2001_m0472, Nv2001_m0473, Nv2001_m0474, Nv2001_m0475, Nv2001_m0476, Nv2001_m0477, Nv2001_m0478, Nv2001_m0479, Nv2001_m0480, Nv2001_m0481, Nv2001_m0482, Nv2001_m0483, Nv2001_m0484, Nv2001_m0485, Nv2001_m0486, Nv2001_m0488, Nv2001_m0489, Nv2001_m0490, Nv2001_m0491, Nv2001_m0492, Nv2001_m0493, Nv2001_m0494, Nv2001_m0495, Nv2001_m0496, Nv2001_m0498, Nv2001_m0499, Nv2001_m0500, Nv2001_m0501, Nv2001_m0502, Nv2001_m0503, Nv2001_m0504, Nv2001_m0506, Nv2001_m0507, Nv2001_m0508, Nv2001_m0509, Nv2001_m0510, Nv2001_m0511, Nv2001_m0512, Nv2001_m0513, Nv2001_m0514, Nv2001_m0515, Nv2001_m0516, Nv2001_m0517, Nv2001_m0518, Nv2001_m0519, Nv2001_m0520, Nv2001_m0521, Nv2001_m0522, Nv2001_m0523, Nv2001_m0524, Nv2001_m0526, Nv2001_m0527, Nv2001_m0528, Nv2001_m0530, Nv2001_m0531, Nv2001_m0532, Nv2001_m0533, Nv2001_m0534, Nv2001_m0535, Nv2001_m0536, Nv2001_m0537, Nv2001_m0538, Nv2001_m0539, Nv2001_m0540, Nv2001_m0541, Nv2001_m0542, Nv2001_m0543, Nv2001_m0544, Nv2001_m0545, Nv2001_m0546, Nv2001_m0547, Nv2001_m0549, Nv2001_m0550, Nv2001_m0551, Nv2001_m0552, Nv2001_m0553, Nv2001_m0554, Nv2001_m0555, Nv2001_m0556, Nv2001_m0557, Nv2001_m0558, Nv2001_m0559, Nv2001_m0560, Nv2001_m0561, Nv2001_m0562 and Nv2001_m0563.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ011140 Genomic DNA. Translation: CAB39164.1.
AF115456 Genomic DNA. Translation: AAF12878.1.
AY779906 Genomic DNA. Translation: AAV59052.1.
AY779907 Genomic DNA. Translation: AAV59064.1.
AY779908 Genomic DNA. Translation: AAV59076.1.
AY779909 Genomic DNA. Translation: AAV59088.1.
AY779910 Genomic DNA. Translation: AAV59100.1.
AY779911 Genomic DNA. Translation: AAV59112.1.
AY779912 Genomic DNA. Translation: AAV59124.1.
AY779913 Genomic DNA. Translation: AAV59136.1.
AY779914 Genomic DNA. Translation: AAV59148.1.
AY779915 Genomic DNA. Translation: AAV59160.1.
AY779916 Genomic DNA. Translation: AAV59172.1.
AY779917 Genomic DNA. Translation: AAV59184.1.
AY779918 Genomic DNA. Translation: AAV59196.1.
AY779919 Genomic DNA. Translation: AAV59208.1.
AY779920 Genomic DNA. Translation: AAV59220.1.
AY779921 Genomic DNA. Translation: AAV59232.1.
AE014297 Genomic DNA. Translation: AAF56547.1.
BT030909 mRNA. Translation: ABV82291.1.
BT030931 mRNA. Translation: ABV82313.1.
BT030967 mRNA. Translation: ABV82349.1.
AY905812 Genomic DNA. Translation: AAX60158.1.
AY905813 Genomic DNA. Translation: AAX60159.1.
AY905814 Genomic DNA. Translation: AAX60160.1.
AY905815 Genomic DNA. Translation: AAX60161.1.
AY905816 Genomic DNA. Translation: AAX60162.1.
AY905817 Genomic DNA. Translation: AAX60163.1.
AY905818 Genomic DNA. Translation: AAX60164.1.
AY905819 Genomic DNA. Translation: AAX60165.1.
AY905820 Genomic DNA. Translation: AAX60166.1.
AY905821 Genomic DNA. Translation: AAX60167.1.
AY905822 Genomic DNA. Translation: AAX60168.1.
AY905823 Genomic DNA. Translation: AAX60169.1.
AY905824 Genomic DNA. Translation: AAX60170.1.
AY905825 Genomic DNA. Translation: AAX60171.1.
AY905826 Genomic DNA. Translation: AAX60172.1.
AY905827 Genomic DNA. Translation: AAX60173.1.
AY905828 Genomic DNA. Translation: AAX60174.1.
AY905829 Genomic DNA. Translation: AAX60175.1.
AY905830 Genomic DNA. Translation: AAX60176.1.
AY905831 Genomic DNA. Translation: AAX60177.1.
AY905832 Genomic DNA. Translation: AAX60178.1.
AY905833 Genomic DNA. Translation: AAX60179.1.
AY905834 Genomic DNA. Translation: AAX60180.1.
AY905835 Genomic DNA. Translation: AAX60181.1.
AY905836 Genomic DNA. Translation: AAX60182.1.
AY905837 Genomic DNA. Translation: AAX60183.1.
AY905838 Genomic DNA. Translation: AAX60184.1.
AY905839 Genomic DNA. Translation: AAX60185.1.
AY905840 Genomic DNA. Translation: AAX60186.1.
AY905841 Genomic DNA. Translation: AAX60187.1.
AY905842 Genomic DNA. Translation: AAX60188.1.
AY905843 Genomic DNA. Translation: AAX60189.1.
AY905844 Genomic DNA. Translation: AAX60190.1.
AY905845 Genomic DNA. Translation: AAX60191.1.
AY905846 Genomic DNA. Translation: AAX60192.1.
AY905847 Genomic DNA. Translation: AAX60193.1.
AY905848 Genomic DNA. Translation: AAX60194.1.
AY905849 Genomic DNA. Translation: AAX60195.1.
AY905850 Genomic DNA. Translation: AAX60196.1.
AY905851 Genomic DNA. Translation: AAX60197.1.
AY905852 Genomic DNA. Translation: AAX60198.1.
AY905853 Genomic DNA. Translation: AAX60199.1.
AY905854 Genomic DNA. Translation: AAX60200.1.
AY905855 Genomic DNA. Translation: AAX60201.1.
AY905856 Genomic DNA. Translation: AAX60202.1.
AY905857 Genomic DNA. Translation: AAX60203.1.
AY905858 Genomic DNA. Translation: AAX60204.1.
AY905859 Genomic DNA. Translation: AAX60205.1.
AY905860 Genomic DNA. Translation: AAX60206.1.
AY905861 Genomic DNA. Translation: AAX60207.1.
AY905862 Genomic DNA. Translation: AAX60208.1.
AY905863 Genomic DNA. Translation: AAX60209.1.
AY905864 Genomic DNA. Translation: AAX60210.1.
AY905865 Genomic DNA. Translation: AAX60211.1.
AY905866 Genomic DNA. Translation: AAX60212.1.
AY905867 Genomic DNA. Translation: AAX60213.1.
AY905868 Genomic DNA. Translation: AAX60214.1.
AY905869 Genomic DNA. Translation: AAX60215.1.
AY905870 Genomic DNA. Translation: AAX60216.1.
AY905871 Genomic DNA. Translation: AAX60217.1.
AY905872 Genomic DNA. Translation: AAX60218.1.
AY905873 Genomic DNA. Translation: AAX60219.1.
AY905874 Genomic DNA. Translation: AAX60220.1.
AY905875 Genomic DNA. Translation: AAX60221.1.
AY905876 Genomic DNA. Translation: AAX60222.1.
AY905877 Genomic DNA. Translation: AAX60223.1.
AY905878 Genomic DNA. Translation: AAX60224.1.
AY905879 Genomic DNA. Translation: AAX60225.1.
AY905880 Genomic DNA. Translation: AAX60226.1.
AY905881 Genomic DNA. Translation: AAX60227.1.
AY905882 Genomic DNA. Translation: AAX60228.1.
AY905883 Genomic DNA. Translation: AAX60229.1.
AY905884 Genomic DNA. Translation: AAX60230.1.
AY905885 Genomic DNA. Translation: AAX60231.1.
AY905886 Genomic DNA. Translation: AAX60232.1.
AY905887 Genomic DNA. Translation: AAX60233.1.
AY905888 Genomic DNA. Translation: AAX60234.1.
AY905889 Genomic DNA. Translation: AAX60235.1.
AY905890 Genomic DNA. Translation: AAX60236.1.
AY905891 Genomic DNA. Translation: AAX60237.1.
AY905892 Genomic DNA. Translation: AAX60238.1.
AY905893 Genomic DNA. Translation: AAX60239.1.
AY905894 Genomic DNA. Translation: AAX60240.1.
AY905895 Genomic DNA. Translation: AAX60241.1.
AY905896 Genomic DNA. Translation: AAX60242.1.
AY905897 Genomic DNA. Translation: AAX60243.1.
AY905898 Genomic DNA. Translation: AAX60244.1.
AY905899 Genomic DNA. Translation: AAX60245.1.
RefSeqNP_524506.1. NM_079782.3.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO97178.

Proteomic databases

PRIDEO97178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0084956; FBpp0084330; FBgn0002732.
GeneID43153.
KEGGdme:Dmel_CG8337.
NMPDRfig|7227.3.peg.14762.

Organism-specific databases

CTD43153.
FlyBaseFBgn0002732. malpha.

Phylogenomic databases

GeneTreeEMGT00050000018163.
InParanoidO97178.
OMAIDENAAN.
OrthoDBEOG408KRJ.
PhylomeDBO97178.

Gene expression databases

BgeeO97178.
GermOnlineCG8337. Drosophila melanogaster.

Family and domain databases

ProtoNetSearch...

Other

NextBio832442.

Entry information

Entry nameESMA_DROME
AccessionPrimary (citable) accession number: O97178
Secondary accession number(s): A8E6W7 expand/collapse secondary AC list , Q56MK8, Q56MK9, Q56ML2, Q56ML4, Q56MM3, Q56MM6, Q56MN5, Q56MP7, Q56MQ1, Q56MQ4, Q56MT0, Q5S4K2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents