Reviewed, UniProtKB/Swiss-Prot O97177 (ESM2_DROME)

Names and origin

Protein names

Recommended name:
    Enhancer of split M2 protein
      Short name=E(spl)m2

Gene names

Name:	m2
ORF Names:	CG6104

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function

Part of the Notch signaling pathway. Ref.1

Developmental stage

Expressed at the time when separation of neural and epidermal precursors cells occurs. Detected in the neuro-ectoderm of stage 9 embryos. At stage 10/11, accumulates at high levels in the presumptive mesoderm, however, it disappears quickly with the onset of germ band retraction. In eye disk, expression occurs close to, as well as posterior to the morphogenetic furrow. In the wing disk, found in the proneural clusters areas, the dorso-ventral boundary and vein/intervein regions. Ref.1

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Notch signaling pathway
Coding sequence diversity	Polymorphism
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Notch signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Enhancer of split M2 protein		PRO_0000087058
Regions
	Compositional bias	66 – 74	9	Poly-Gln
	Compositional bias	152 – 157	6	Poly-Ser
Natural variations
	Natural variant	186	1	G → D

Sequences

	Sequence		Length	Mass (Da)
	O97177-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 8DC97662E9B0BE13	FASTA	218	24,118
	10 20 30 40 50 60 MYLDTKNLTA SSTSALTAAT ASNSKSTRRM RNVWKPLSRL LKVGGKGRTA QATLAHPNNV 70 80 90 100 110 120 DLNNTQQQQQ QQQQELLIED DTKSTPEESI HKYGLELRQL PEEEQVSLTQ PPNTPTLISS 130 140 150 160 170 180 VHVDKVSAQS CGNCQHGRNC QHRHHSSSNI NSSSSSSNMN SSSATQLPSN LWDLQLPLQY 190 200 210 ISTDNGTFFW ANTQDRVDDD LLHALLCQSF SQLPGTLC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes." Wurmbach E., Wech I., Preiss A. Mech. Dev. 80:171-180(1999) [PubMed: 10072784] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ010168 Genomic DNA. Translation: CAB39174.1. AE014297 Genomic DNA. Translation: AAF56549.1. AY071096 mRNA. Translation: AAL48718.1.
RefSeq	NP_524508.1.
UniGene	Dm.2354
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O97177.
Genome annotation databases
Ensembl	FBgn0002592. Drosophila melanogaster. [Contig view]
GeneID	43155.
KEGG	dme:Dmel_CG6104.
Organism-specific databases
FlyBase	FBgn0002592. m2.
Phylogenomic databases
OMA	O97177. FFWANTQ.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-013500-MON.
Gene expression databases
ArrayExpress	O97177.
GermOnline	CG6104. Drosophila melanogaster.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	832452.

Entry information

Entry name

ESM2_DROME

Accession

Primary (citable) accession number: O97177

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project