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O97177 (ESM2_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enhancer of split M2 protein
Short name=E(spl)m2
Gene names
Name:m2
ORF Names:CG6104
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the Notch signaling pathway. Ref.1

Developmental stage

Expressed at the time when separation of neural and epidermal precursors cells occurs. Detected in the neuro-ectoderm of stage 9 embryos. At stage 10/11, accumulates at high levels in the presumptive mesoderm, however, it disappears quickly with the onset of germ band retraction. In eye disk, expression occurs close to, as well as posterior to the morphogenetic furrow. In the wing disk, found in the proneural clusters areas, the dorso-ventral boundary and vein/intervein regions. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Enhancer of split M2 protein
PRO_0000087058

Regions

Compositional bias66 – 749Poly-Gln
Compositional bias152 – 1576Poly-Ser

Natural variations

Natural variant121S → T in strain: NVIII-41. Ref.2
Natural variant211Missing in strain: NVIII-m11.
Natural variant471G → C in strain: NVIII-9. Ref.2
Natural variant651T → TQQQQ in strain: NVIII-m11.
Natural variant150 – 1589Missing in strain: NVIII-42 and NVIII-18.
Natural variant150 – 1534Missing in strain: Madang_F12 and Madang_M22.
Natural variant2121Q → E in strain: NVIII-m13. Ref.2
Natural variant2131L → M in strain: NVIII-m11. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O97177 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 8DC97662E9B0BE13

FASTA21824,118
        10         20         30         40         50         60 
MYLDTKNLTA SSTSALTAAT ASNSKSTRRM RNVWKPLSRL LKVGGKGRTA QATLAHPNNV 

        70         80         90        100        110        120 
DLNNTQQQQQ QQQQELLIED DTKSTPEESI HKYGLELRQL PEEEQVSLTQ PPNTPTLISS 

       130        140        150        160        170        180 
VHVDKVSAQS CGNCQHGRNC QHRHHSSSNI NSSSSSSNMN SSSATQLPSN LWDLQLPLQY 

       190        200        210 
ISTDNGTFFW ANTQDRVDDD LLHALLCQSF SQLPGTLC

« Hide

References

« Hide 'large scale' references
[1]"The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes."
Wurmbach E., Wech I., Preiss A.
Mech. Dev. 80:171-180(1999) [PubMed: 10072784] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE.
Tissue: Embryo.
[2]"Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila."
Macdonald S.J., Long A.D.
Mol. Biol. Evol. 22:607-619(2005) [PubMed: 15537803] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-12; ALA-21 DEL; CYS-47; GLN-GLN-GLN-GLN-66 INS; 150-ILE--SER-153 DEL; 150-ILE--ASN-158 DEL; GLU-212 AND MET-213.
Strain: Madang_F12, Madang_F16, Madang_F18, Madang_F21, Madang_F24, Madang_F30, Madang_F4, Madang_F9, Madang_M10, Madang_M17, Madang_M22, Madang_M27, Madang_M3, Madang_M4, Madang_M9, NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ010168 Genomic DNA. Translation: CAB39174.1.
AY779906 Genomic DNA. Translation: AAV59054.1.
AY779907 Genomic DNA. Translation: AAV59066.1.
AY779908 Genomic DNA. Translation: AAV59078.1.
AY779909 Genomic DNA. Translation: AAV59090.1.
AY779910 Genomic DNA. Translation: AAV59102.1.
AY779911 Genomic DNA. Translation: AAV59114.1.
AY779912 Genomic DNA. Translation: AAV59126.1.
AY779913 Genomic DNA. Translation: AAV59138.1.
AY779914 Genomic DNA. Translation: AAV59150.1.
AY779915 Genomic DNA. Translation: AAV59162.1.
AY779916 Genomic DNA. Translation: AAV59174.1.
AY779917 Genomic DNA. Translation: AAV59186.1.
AY779918 Genomic DNA. Translation: AAV59198.1.
AY779919 Genomic DNA. Translation: AAV59210.1.
AY779920 Genomic DNA. Translation: AAV59222.1.
AY779921 Genomic DNA. Translation: AAV59234.1.
AY779933 Genomic DNA. Translation: AAV59030.1.
AY779934 Genomic DNA. Translation: AAV59031.1.
AY779935 Genomic DNA. Translation: AAV59032.1.
AY779936 Genomic DNA. Translation: AAV59033.1.
AY779937 Genomic DNA. Translation: AAV59034.1.
AY779938 Genomic DNA. Translation: AAV59035.1.
AY779939 Genomic DNA. Translation: AAV59036.1.
AY779940 Genomic DNA. Translation: AAV59037.1.
AY779941 Genomic DNA. Translation: AAV59038.1.
AY779942 Genomic DNA. Translation: AAV59039.1.
AY779943 Genomic DNA. Translation: AAV59040.1.
AY779944 Genomic DNA. Translation: AAV59041.1.
AY779945 Genomic DNA. Translation: AAV59042.1.
AY779946 Genomic DNA. Translation: AAV59043.1.
AY779947 Genomic DNA. Translation: AAV59044.1.
AE014297 Genomic DNA. Translation: AAF56549.1.
AY071096 mRNA. Translation: AAL48718.1.
RefSeqNP_524508.1. NM_079784.3.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO97177.

Proteomic databases

PRIDEO97177.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0084981; FBpp0084354; FBgn0002592.
GeneID43155.
KEGGdme:Dmel_CG6104.

Organism-specific databases

CTD43155.
FlyBaseFBgn0002592. m2.

Phylogenomic databases

GeneTreeEMGT00050000022924.
InParanoidO97177.
OMAFFWANTQ.
OrthoDBEOG40GB79.
PhylomeDBO97177.

Gene expression databases

ArrayExpressO97177.
BgeeO97177.
GermOnlineCG6104. Drosophila melanogaster.

Family and domain databases

ProtoNetSearch...

Other

NextBio832452.

Entry information

Entry nameESM2_DROME
AccessionPrimary (citable) accession number: O97177
Secondary accession number(s): Q5S3Y0 expand/collapse secondary AC list , Q5S3Y1, Q5S3Y3, Q5S456, Q5S480, Q5S4A4, Q5S4B6, Q5S4H6, Q5S4K0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents