O97157 (ADAS_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Alkyldihydroxyacetonephosphate synthase Short name=Alkyl-DHAP synthase EC=2.5.1.26 Alternative name(s): Alkylglycerone-phosphate synthase
Organism	Trypanosoma brucei brucei
Taxonomic identifier	5702 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	613 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.
Cofactor	FAD By similarity.
Pathway	Glycerolipid metabolism; ether lipid biosynthesis.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the FAD-binding oxidoreductase/transferase type 4 family. Contains 1 FAD-binding PCMH-type domain.

Ontologies

Keywords
Biological process	Lipid synthesis
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Transferase
Gene Ontology (GO)
Biological process	lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylmuramate dehydrogenase activity Inferred from electronic annotation. Source: InterPro alkylglycerone-phosphate synthase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 613	613	Alkyldihydroxyacetonephosphate synthase		PRO_0000128180
Regions
	Domain	126 – 307	182	FAD-binding PCMH-type
	Motif	611 – 613	3	Microbody targeting signal Potential
Sites
	Active site	498	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O97157 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 27BA9FBF2EB94E3A	FASTA	613	69,068
	10 20 30 40 50 60 MDKRMITDAF EEIKWNGWGD TGVCIKYDEA RQLPIHTNGK PMKHLLKFMK DDVLKVKGEF 70 80 90 100 110 120 KIKPTPGLTK EEAIKRLPPP VVKQPFVDEL RQVLSKDQIR LDAYARLTHI FGKNYRDLWR 130 140 150 160 170 180 VRRGMIDRPP DAVILPNNHD DCVKIMELAQ KHNVVVVPFG GGTNVTGGVE PNPFETRRMV 190 200 210 220 230 240 ISIDMRRMGR MLHIDTESGT AVFEVGVLGP DIDEQLSRYG FMMGHDPDSY AYSTLGGWIA 250 260 270 280 290 300 ARGSGAMSNK YGDIENMILA MRVVTPVGVV ETPLTSRPCG VDLNAMFVGS EGAFGLVTEA 310 320 330 340 350 360 VVKIERLPEV KRYEGWLFPS FEVAFTAFHT CTRKGIHPCT MRLYDEDDTR LSFAASTDSG 370 380 390 400 410 420 LVSTFFSKCF KKYIATVKGW NLSKISLVVV GFEGTKAQTN CQRSELVGVF QAFGATCLGT 430 440 450 460 470 480 KPGNTWQEKK YDLPYLRDFA LAHNFWADVF ETSVLYTDAI HCWRAVKKSF AEVMAENGKN 490 500 510 520 530 540 AWIGCHTAHQ YRFGCCLYFT FIGGQADEND LKIFLQVKKR AMEVMLQHRG NLTHHHGIGY 550 560 570 580 590 600 EHVPWMKRYN GEGGLDAIMK FKKALDPKNI CNPGKLLPSP PSEKETPKAT QARQNREMMF 610 DKMGIPGALQ AHL

References

[1]	"Molecular characterization of Trypanosoma brucei alkyl-dihydroxyacetonephosphate synthase." Zomer A.M.W., Michels P.A.M., Opperdoes F.R. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF119091 Genomic DNA. Translation: AAD19697.1.
3D structure databases
ProteinModelPortal	O97157.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR016164. FAD-linked_Oxase-like_C. IPR016168. FAD-linked_Oxase_FAD-bd_sub2. IPR004113. FAD-linked_oxidase_C. IPR006094. Oxid_FAD_bind_N. IPR016171. Vanillyl_alc_oxidase_C-sub2. [Graphical view]
Gene3D	G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.30.465.20. FAD-linked_oxidase_FAD-bd_sub2. 1 hit. G3DSA:1.10.45.10. Vanillyl_alc_oxidase_C-sub2. 1 hit.
Pfam	PF02913. FAD-oxidase_C. 1 hit. PF01565. FAD_binding_4. 1 hit. [Graphical view]
SUPFAM	SSF55103. FAD-binding_2. 1 hit. SSF56176. FAD-binding_2. 1 hit.
PROSITE	PS51387. FAD_PCMH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADAS_TRYBB

Accession

Primary (citable) accession number: O97157

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	October 19, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)