Reviewed, UniProtKB/Swiss-Prot O97125 (HSP68_DROME)

Names and origin

Protein names

Recommended name:
    Heat shock protein 68

Gene names

Name:	Hsp68
ORF Names:	CG5436

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	determination of adult life span Inferred from mutant phenotype. Source: FlyBase response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	Heat shock protein 68		PRO_0000078328
Amino acid modifications
	Modified residue	127	1	Phosphothreonine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O97125-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B3A429D415BA8035	FASTA	635	69,744
	10 20 30 40 50 60 MPAIGIDLGT TYSCVGVFQY GKVEIIANDQ GNRTTPSYVA FTDSERLIGD AAKNQVAMNP 70 80 90 100 110 120 KNSVFDAKRL IGRRFDDSKI QEDIKHWPFK VINDNGKPKI SVEFKGANKC FSPEEISSMV 130 140 150 160 170 180 LTKMKETAEA YLGTTVKDAV ITVPAYFNDS QRQATKDAGA IAGINVLRII NEPTAAALAY 190 200 210 220 230 240 GLDKNLKGER NVLIFDLGGG TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVNHFA 250 260 270 280 290 300 EEFKRKYKKD LRSNPRALRR LRTAAERAKR TLSSSTEASL EIDALYEGHD FYSKVSRARF 310 320 330 340 350 360 EELCGDLFRN TLEPVEKALK DAKMDKSQIH DIVLVGGSTR IPKVQNLLQN FFGGKTLNLS 370 380 390 400 410 420 INPDEAVAYG AAIQAAILSG DKSSEIKDVL LVDVAPLSLG IETAGGVMTK LIERNSRIPC 430 440 450 460 470 480 KQSKTFTTYA DNQPAVTIQV FEGERALTKD NNVLGTFDLT GVPPAPRGVP KIDVTFDLDA 490 500 510 520 530 540 NGILNVTAKE QGTGNAKNIT IKNDKGRLSQ ADIDRMLSEA EKYAEEDERH RQRIAARNQL 550 560 570 580 590 600 ETYLFGVKEA AENGGDRISA ADKSSIVERC SEAMKWLDSN TTAEKEEYEY KLKELEQFCS 610 620 630 PIMTKMHKGG GDGQQAPNFG QQAGGYKGPT VEEVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The heat shock gene hsp68 of D. melanogaster." McColl G., McKechnie S.W. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-127, MASS SPECTROMETRY. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF096275 Genomic DNA. Translation: AAD16140.1. AE014297 Genomic DNA. Translation: AAF56230.1. AY094878 mRNA. Translation: AAM11231.1.
RefSeq	NP_524474.1.
UniGene	Dm.23337
3D structure databases
HSSP	HSSP built from PDB template 3HSC based on UniProtKB P19120.
SMR	O97125. Positions 2-552.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:19523N.
IntAct	O97125. 8 interactions.
Proteomic databases
PRIDE	O97125.
Genome annotation databases
Ensembl	FBgn0001230. Drosophila melanogaster. [Contig view]
GeneID	42852.
KEGG	dme:Dmel_CG5436.
NMPDR	fig|7227.3.peg.14358.
Organism-specific databases
FlyBase	FBgn0001230. Hsp68.
Phylogenomic databases
HOGENOM	O97125.
OMA	O97125. NGGDRIS.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-013103-MON.
Gene expression databases
ArrayExpress	O97125.
GermOnline	CG5436. Drosophila melanogaster.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
ProDom	PD000089. Hsp70. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	830925.

Entry information

Entry name

HSP68_DROME

Accession

Primary (citable) accession number: O97125

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project