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O97125 (HSP68_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock protein 68
Gene names
Name:Hsp68
ORF Names:CG5436
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   LigandATP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdetermination of adult lifespan

Inferred from mutant phenotype. Source: FlyBase

response to methotrexate

Inferred from expression pattern. Source: FlyBase

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmicrotubule associated complex

Inferred from direct assay. Source: FlyBase

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Heat shock protein 68
PRO_0000078328

Amino acid modifications

Modified residue1271Phosphothreonine Ref.5

Sequences

Sequence LengthMass (Da)Tools
O97125 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B3A429D415BA8035

FASTA63569,744
        10         20         30         40         50         60 
MPAIGIDLGT TYSCVGVFQY GKVEIIANDQ GNRTTPSYVA FTDSERLIGD AAKNQVAMNP 

        70         80         90        100        110        120 
KNSVFDAKRL IGRRFDDSKI QEDIKHWPFK VINDNGKPKI SVEFKGANKC FSPEEISSMV 

       130        140        150        160        170        180 
LTKMKETAEA YLGTTVKDAV ITVPAYFNDS QRQATKDAGA IAGINVLRII NEPTAAALAY 

       190        200        210        220        230        240 
GLDKNLKGER NVLIFDLGGG TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVNHFA 

       250        260        270        280        290        300 
EEFKRKYKKD LRSNPRALRR LRTAAERAKR TLSSSTEASL EIDALYEGHD FYSKVSRARF 

       310        320        330        340        350        360 
EELCGDLFRN TLEPVEKALK DAKMDKSQIH DIVLVGGSTR IPKVQNLLQN FFGGKTLNLS 

       370        380        390        400        410        420 
INPDEAVAYG AAIQAAILSG DKSSEIKDVL LVDVAPLSLG IETAGGVMTK LIERNSRIPC 

       430        440        450        460        470        480 
KQSKTFTTYA DNQPAVTIQV FEGERALTKD NNVLGTFDLT GVPPAPRGVP KIDVTFDLDA 

       490        500        510        520        530        540 
NGILNVTAKE QGTGNAKNIT IKNDKGRLSQ ADIDRMLSEA EKYAEEDERH RQRIAARNQL 

       550        560        570        580        590        600 
ETYLFGVKEA AENGGDRISA ADKSSIVERC SEAMKWLDSN TTAEKEEYEY KLKELEQFCS 

       610        620        630 
PIMTKMHKGG GDGQQAPNFG QQAGGYKGPT VEEVD

« Hide

References

« Hide 'large scale' references
[1]"The heat shock gene hsp68 of D. melanogaster."
McColl G., McKechnie S.W.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-127, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF096275 Genomic DNA. Translation: AAD16140.1.
AE014297 Genomic DNA. Translation: AAF56230.1.
AY094878 mRNA. Translation: AAM11231.1.
RefSeqNP_524474.1. NM_079750.3.
UniGeneDm.23337.

3D structure databases

ProteinModelPortalO97125.
SMRO97125. Positions 1-613.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-19523N.
MINTMINT-854915.
STRINGO97125.

Proteomic databases

PRIDEO97125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0084589; FBpp0083974; FBgn0001230.
GeneID42852.
KEGGdme:Dmel_CG5436.
NMPDRfig|7227.3.peg.14358.

Organism-specific databases

CTD42852.
FlyBaseFBgn0001230. Hsp68.

Phylogenomic databases

eggNOGmeNOG23846.
GeneTreeEMGT00050000004323.
InParanoidO97125.
OMANGGDRIS.
OrthoDBEOG48SF85.
PhylomeDBO97125.

Gene expression databases

BgeeO97125.
GermOnlineCG5436. Drosophila melanogaster.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR001023. Hsp70.
IPR013126. Hsp_70.
[Graphical view]
KOK03283.
PANTHERPTHR19375. Hsp70. 1 hit.
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio830925.

Entry information

Entry nameHSP68_DROME
AccessionPrimary (citable) accession number: O97125
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents