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Protein

Heat shock protein 68

Gene

Hsp68

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: FlyBase
  • protein folding Source: FlyBase
  • response to starvation Source: FlyBase

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 68
Gene namesi
Name:Hsp68
ORF Names:CG5436
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001230. Hsp68.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783281 – 635Heat shock protein 68Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO97125.
PRIDEiO97125.

PTM databases

iPTMnetiO97125.

Expressioni

Gene expression databases

BgeeiFBgn0001230.
GenevisibleiO97125. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi67786. 17 interactors.
DIPiDIP-19523N.
MINTiMINT-854915.
STRINGi7227.FBpp0083974.

Structurei

3D structure databases

ProteinModelPortaliO97125.
SMRiO97125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
InParanoidiO97125.
KOiK03283.
OMAiAEEDERH.
OrthoDBiEOG091G03SF.
PhylomeDBiO97125.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O97125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIGIDLGT TYSCVGVFQY GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
AAKNQVAMNP KNSVFDAKRL IGRRFDDSKI QEDIKHWPFK VINDNGKPKI
110 120 130 140 150
SVEFKGANKC FSPEEISSMV LTKMKETAEA YLGTTVKDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGA IAGINVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVNHFA EEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEASL EIDALYEGHD FYSKVSRARF
310 320 330 340 350
EELCGDLFRN TLEPVEKALK DAKMDKSQIH DIVLVGGSTR IPKVQNLLQN
360 370 380 390 400
FFGGKTLNLS INPDEAVAYG AAIQAAILSG DKSSEIKDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNSRIPC KQSKTFTTYA DNQPAVTIQV FEGERALTKD
460 470 480 490 500
NNVLGTFDLT GVPPAPRGVP KIDVTFDLDA NGILNVTAKE QGTGNAKNIT
510 520 530 540 550
IKNDKGRLSQ ADIDRMLSEA EKYAEEDERH RQRIAARNQL ETYLFGVKEA
560 570 580 590 600
AENGGDRISA ADKSSIVERC SEAMKWLDSN TTAEKEEYEY KLKELEQFCS
610 620 630
PIMTKMHKGG GDGQQAPNFG QQAGGYKGPT VEEVD
Length:635
Mass (Da):69,744
Last modified:May 1, 1999 - v1
Checksum:iB3A429D415BA8035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096275 Genomic DNA. Translation: AAD16140.1.
AE014297 Genomic DNA. Translation: AAF56230.1.
AY094878 mRNA. Translation: AAM11231.1.
RefSeqiNP_524474.1. NM_079750.4.
UniGeneiDm.23337.

Genome annotation databases

EnsemblMetazoaiFBtr0084589; FBpp0083974; FBgn0001230.
GeneIDi42852.
KEGGidme:Dmel_CG5436.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHSP68_DROME
AccessioniPrimary (citable) accession number: O97125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families