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Protein
Submitted name:

LD29223p

Gene

par-6

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • apical protein localization Source: FlyBase
  • asymmetric neuroblast division Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • branching involved in open tracheal system development Source: FlyBase
  • cell adhesion Source: FlyBase
  • epithelium development Source: FlyBase
  • establishment of neuroblast polarity Source: FlyBase
  • establishment or maintenance of epithelial cell apical/basal polarity Source: FlyBase
  • establishment or maintenance of neuroblast polarity Source: FlyBase
  • establishment or maintenance of polarity of embryonic epithelium Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • morphogenesis of a polarized epithelium Source: FlyBase
  • negative regulation of protein kinase activity Source: FlyBase
  • oocyte axis specification Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase
  • positive regulation of lamellipodium assembly Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • synapse assembly Source: FlyBase
  • terminal branching, open tracheal system Source: FlyBase
  • zonula adherens assembly Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-DME-4608870. Asymmetric localization of PCP proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
LD29223pImported
Submitted name:
PAR-6Imported
Submitted name:
Par-6, isoform AImported
Submitted name:
Par-6, isoform BImported
Gene namesi
Name:par-6Imported
ORF Names:CG5884Imported, Dmel_CG5884Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0026192. par-6.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: FlyBase
  • apical plasma membrane Source: FlyBase
  • cell cortex Source: FlyBase
  • muscle cell postsynaptic density Source: FlyBase
  • subapical complex Source: FlyBase
  • terminal bouton Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-17759N.
MINTiMINT-156165.
STRINGi7227.FBpp0074229.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RY4NMR-A130-255[»]
1RZXX-ray2.10A156-253[»]
1X8SX-ray2.50A156-255[»]
2LC6NMR-A130-255[»]
2LC7NMR-A156-255[»]
5I7ZX-ray1.80A158-253[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 10183PB1InterPro annotationAdd
BLAST
Domaini160 – 25394PDZ (DHR)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains PB1 domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
KOiK06093.
OMAiIEDSGEP.
OrthoDBiEOG73JKWB.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNKINTTS ATAASDTNLI EVKSKFDAEF RRWSFKRNEA EQSFDKFASL
60 70 80 90 100
IEQLHKLTNI QFLILYIDPR DNDLLPINND DNFGRALKTA RPLLRVIVQR
110 120 130 140 150
KDDLNEYSGF GTMKPRNLIG SILMGHTPVK TKAPSISIPH DFRQVSAIID
160 170 180 190 200
VDIVPETHRR VRLLKHGSDK PLGFYIRDGT SVRVTASGLE KQPGIFISRL
210 220 230 240 250
VPGGLAESTG LLAVNDEVIE VNGIEVAGKT LDQVTDMMVA NSSNLIITVK
260 270 280 290 300
PANQRTLTST HRGSFSRNSQ LSSGSHHTNN TNTSDEIEHD DQDDIVDLTG
310 320 330 340 350
VTLDESPTST SAGNHNHQPP LSSSPSSHHQ QAASNASTIM ASDVKDGVLH

L
Length:351
Mass (Da):38,520
Last modified:May 1, 1999 - v1
Checksum:i3097047D5348C84C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070969 mRNA. Translation: AAD15927.1.
AE014298 Genomic DNA. Translation: AAF48757.1.
AY061369 mRNA. Translation: AAL28917.1.
AE014298 Genomic DNA. Translation: AAN09592.1.
RefSeqiNP_573238.1. NM_133010.5.
NP_728094.1. NM_167575.2.
UniGeneiDm.3245.

Genome annotation databases

EnsemblMetazoaiFBtr0074455; FBpp0074229; FBgn0026192.
FBtr0074456; FBpp0074230; FBgn0026192.
GeneIDi32752.
KEGGidme:Dmel_CG5884.
UCSCiCG5884-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070969 mRNA. Translation: AAD15927.1.
AE014298 Genomic DNA. Translation: AAF48757.1.
AY061369 mRNA. Translation: AAL28917.1.
AE014298 Genomic DNA. Translation: AAN09592.1.
RefSeqiNP_573238.1. NM_133010.5.
NP_728094.1. NM_167575.2.
UniGeneiDm.3245.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RY4NMR-A130-255[»]
1RZXX-ray2.10A156-253[»]
1X8SX-ray2.50A156-255[»]
2LC6NMR-A130-255[»]
2LC7NMR-A156-255[»]
5I7ZX-ray1.80A158-253[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-17759N.
MINTiMINT-156165.
STRINGi7227.FBpp0074229.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074455; FBpp0074229; FBgn0026192.
FBtr0074456; FBpp0074230; FBgn0026192.
GeneIDi32752.
KEGGidme:Dmel_CG5884.
UCSCiCG5884-RA. d. melanogaster.

Organism-specific databases

CTDi32752.
FlyBaseiFBgn0026192. par-6.

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
KOiK06093.
OMAiIEDSGEP.
OrthoDBiEOG73JKWB.

Enzyme and pathway databases

ReactomeiR-DME-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-DME-4608870. Asymmetric localization of PCP proteins.

Miscellaneous databases

ChiTaRSipar-6. fly.
GenomeRNAii32752.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos."
    Hung T.-J., Kemphues K.J.
    Development 126:127-135(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  6. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition."
    Peterson F.C., Penkert R.R., Volkman B.F., Prehoda K.E.
    Mol. Cell 13:665-676(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 130-255.
  9. "Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex."
    Penkert R.R., DiVittorio H.M., Prehoda K.E.
    Nat. Struct. Mol. Biol. 11:1122-1127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 156-255.
  10. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  15. "A conformational switch in the CRIB-PDZ module of Par-6."
    Whitney D.S., Peterson F.C., Volkman B.F.
    Structure 19:1711-1722(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 130-255.
  16. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  17. "Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42."
    Whitney D.S., Peterson F.C., Kittell A.W., Egner J.M., Prehoda K.E., Volkman B.F.
    Biochemistry 55:1455-1461(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 158-253.

Entry informationi

Entry nameiO97111_DROME
AccessioniPrimary (citable) accession number: O97111
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.