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Protein
Submitted name:

LD29223p

Gene

par-6

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • apical protein localization Source: FlyBase
  • asymmetric neuroblast division Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • branching involved in open tracheal system development Source: FlyBase
  • cell adhesion Source: FlyBase
  • epithelium development Source: FlyBase
  • establishment of neuroblast polarity Source: FlyBase
  • establishment or maintenance of epithelial cell apical/basal polarity Source: FlyBase
  • establishment or maintenance of neuroblast polarity Source: FlyBase
  • establishment or maintenance of polarity of embryonic epithelium Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • morphogenesis of a polarized epithelium Source: FlyBase
  • negative regulation of protein kinase activity Source: FlyBase
  • oocyte axis specification Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase
  • positive regulation of lamellipodium assembly Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • synapse assembly Source: FlyBase
  • terminal branching, open tracheal system Source: FlyBase
  • zonula adherens assembly Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-DME-4608870. Asymmetric localization of PCP proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
LD29223pImported
Submitted name:
PAR-6Imported
Submitted name:
Par-6, isoform AImported
Submitted name:
Par-6, isoform BImported
Gene namesi
Name:par-6Imported
ORF Names:CG5884Imported, Dmel_CG5884Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0026192. par-6.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: FlyBase
  • apical plasma membrane Source: FlyBase
  • cell cortex Source: FlyBase
  • muscle cell postsynaptic density Source: FlyBase
  • subapical complex Source: FlyBase
  • terminal bouton Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0026192.

Interactioni

Protein-protein interaction databases

DIPiDIP-17759N.
MINTiMINT-156165.
STRINGi7227.FBpp0074229.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RY4NMR-A130-255[»]
1RZXX-ray2.10A156-253[»]
1X8SX-ray2.50A156-255[»]
2LC6NMR-A130-255[»]
2LC7NMR-A156-255[»]
5I7ZX-ray1.80A158-253[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 101PB1InterPro annotationAdd BLAST83
Domaini160 – 253PDZ (DHR)InterPro annotationAdd BLAST94

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
KOiK06093.
OMAiIEDSGEP.
OrthoDBiEOG091G0FFH.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNKINTTS ATAASDTNLI EVKSKFDAEF RRWSFKRNEA EQSFDKFASL
60 70 80 90 100
IEQLHKLTNI QFLILYIDPR DNDLLPINND DNFGRALKTA RPLLRVIVQR
110 120 130 140 150
KDDLNEYSGF GTMKPRNLIG SILMGHTPVK TKAPSISIPH DFRQVSAIID
160 170 180 190 200
VDIVPETHRR VRLLKHGSDK PLGFYIRDGT SVRVTASGLE KQPGIFISRL
210 220 230 240 250
VPGGLAESTG LLAVNDEVIE VNGIEVAGKT LDQVTDMMVA NSSNLIITVK
260 270 280 290 300
PANQRTLTST HRGSFSRNSQ LSSGSHHTNN TNTSDEIEHD DQDDIVDLTG
310 320 330 340 350
VTLDESPTST SAGNHNHQPP LSSSPSSHHQ QAASNASTIM ASDVKDGVLH

L
Length:351
Mass (Da):38,520
Last modified:May 1, 1999 - v1
Checksum:i3097047D5348C84C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070969 mRNA. Translation: AAD15927.1.
AE014298 Genomic DNA. Translation: AAF48757.1.
AY061369 mRNA. Translation: AAL28917.1.
AE014298 Genomic DNA. Translation: AAN09592.1.
RefSeqiNP_573238.1. NM_133010.5.
NP_728094.1. NM_167575.2.
UniGeneiDm.3245.

Genome annotation databases

EnsemblMetazoaiFBtr0074455; FBpp0074229; FBgn0026192.
FBtr0074456; FBpp0074230; FBgn0026192.
GeneIDi32752.
KEGGidme:Dmel_CG5884.
UCSCiCG5884-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070969 mRNA. Translation: AAD15927.1.
AE014298 Genomic DNA. Translation: AAF48757.1.
AY061369 mRNA. Translation: AAL28917.1.
AE014298 Genomic DNA. Translation: AAN09592.1.
RefSeqiNP_573238.1. NM_133010.5.
NP_728094.1. NM_167575.2.
UniGeneiDm.3245.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RY4NMR-A130-255[»]
1RZXX-ray2.10A156-253[»]
1X8SX-ray2.50A156-255[»]
2LC6NMR-A130-255[»]
2LC7NMR-A156-255[»]
5I7ZX-ray1.80A158-253[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-17759N.
MINTiMINT-156165.
STRINGi7227.FBpp0074229.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074455; FBpp0074229; FBgn0026192.
FBtr0074456; FBpp0074230; FBgn0026192.
GeneIDi32752.
KEGGidme:Dmel_CG5884.
UCSCiCG5884-RA. d. melanogaster.

Organism-specific databases

CTDi32752.
FlyBaseiFBgn0026192. par-6.

Phylogenomic databases

eggNOGiKOG3606. Eukaryota.
ENOG410XRJ3. LUCA.
GeneTreeiENSGT00390000005255.
KOiK06093.
OMAiIEDSGEP.
OrthoDBiEOG091G0FFH.

Enzyme and pathway databases

ReactomeiR-DME-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-DME-4608870. Asymmetric localization of PCP proteins.

Miscellaneous databases

ChiTaRSipar-6. fly.
GenomeRNAii32752.

Gene expression databases

BgeeiFBgn0026192.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR000270. PB1_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO97111_DROME
AccessioniPrimary (citable) accession number: O97111
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.