O97111 (O97111_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LD29223p EMBL AAL28917.1

Submitted name:
PAR-6 EMBL AAD15927.1
Submitted name:
Par-6 EMBL AAF48757.1

Gene names

Name:	par-6 EMBL AAF48757.1 FlyBase FBgn0026192
ORF Names:	CG5884 FlyBase FBgn0026192, Dmel_CG5884 EMBL AAF48757.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain. RuleBase RU003354

Ontologies

Keywords
Technical term	3D-structure PDB 1RZX PDB 1RY4 PDB 1X8S Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apical protein localization Non-traceable author statement. Source: FlyBase asymmetric neuroblast division Inferred from genetic interaction. Source: FlyBase border follicle cell migration Inferred from mutant phenotype. Source: FlyBase cell adhesion Inferred from mutant phenotype. Source: FlyBase establishment of neuroblast polarity Inferred from mutant phenotype. Source: FlyBase establishment or maintenance of epithelial cell apical/basal polarity Non-traceable author statement. Source: FlyBase establishment or maintenance of polarity of embryonic epithelium Non-traceable author statement. Source: FlyBase morphogenesis of a polarized epithelium Traceable author statement. Source: FlyBase negative regulation of protein kinase activity Inferred from direct assay. Source: FlyBase oocyte axis specification Traceable author statement. Source: FlyBase phagocytosis, engulfment Inferred from mutant phenotype. Source: FlyBase regulation of cell shape Inferred from mutant phenotype. Source: FlyBase synapse assembly Inferred from mutant phenotype. Source: FlyBase zonula adherens assembly Non-traceable author statement. Source: FlyBase
Cellular component	apical cortex Inferred from direct assay. Source: FlyBase apical plasma membrane Traceable author statement. Source: FlyBase subapical complex Traceable author statement. Source: FlyBase
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O97111 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3097047D5348C84C	FASTA	351	38,520
	10 20 30 40 50 60 MSKNKINTTS ATAASDTNLI EVKSKFDAEF RRWSFKRNEA EQSFDKFASL IEQLHKLTNI 70 80 90 100 110 120 QFLILYIDPR DNDLLPINND DNFGRALKTA RPLLRVIVQR KDDLNEYSGF GTMKPRNLIG 130 140 150 160 170 180 SILMGHTPVK TKAPSISIPH DFRQVSAIID VDIVPETHRR VRLLKHGSDK PLGFYIRDGT 190 200 210 220 230 240 SVRVTASGLE KQPGIFISRL VPGGLAESTG LLAVNDEVIE VNGIEVAGKT LDQVTDMMVA 250 260 270 280 290 300 NSSNLIITVK PANQRTLTST HRGSFSRNSQ LSSGSHHTNN TNTSDEIEHD DQDDIVDLTG 310 320 330 340 350 VTLDESPTST SAGNHNHQPP LSSSPSSHHQ QAASNASTIM ASDVKDGVLH L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos." Hung T.-J., Kemphues K.J. Development 126:127-135(1999) [PubMed: 9834192] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition." Peterson F.C., Penkert R.R., Volkman B.F., Prehoda K.E. Mol. Cell 13:665-676(2004) [PubMed: 15023337] [Abstract] Cited for: STRUCTURE BY NMR OF 130-255.
[4]	"Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex." Penkert R.R., DiVittorio H.M., Prehoda K.E. Nat. Struct. Mol. Biol. 11:1122-1127(2004) [PubMed: 15475968] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 156-255.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[6]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL28917.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF070969 mRNA. Translation: AAD15927.1.
AE014298 Genomic DNA. Translation: AAF48757.1.
AY061369 mRNA. Translation: AAL28917.1.

RefSeq

NP_573238.1. NM_133010.4.

UniGene

Dm.3245.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RY4	NMR	-	A	130-255	[»]
1RZX	X-ray	2.10	A	156-253	[»]
1X8S	X-ray	2.50	A	156-255	[»]
2LC6	NMR	-	A	130-255	[»]
2LC7	NMR	-	A	156-255	[»]

ProteinModelPortal

O97111.

SMR

O97111. Positions 18-101, 130-255.

ModBase

Search...

Protein-protein interaction databases

IntAct

O97111. 11 interactions.

MINT

MINT-156165.

STRING

O97111.

Proteomic databases

PRIDE

O97111.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0074455; FBpp0074229; FBgn0026192.

GeneID

32752.

KEGG

dme:Dmel_CG5884.

UCSC

CG5884-RA. d. melanogaster.

Organism-specific databases

CTD

32752.

FlyBase

FBgn0026192. par-6.

Phylogenomic databases

eggNOG

inNOG04370.

GeneTree

EMGT00050000014401.

InParanoid

O97111.

OMA

LYIDPRD.

OrthoDB

EOG4JM659.

PhylomeDB

O97111.

Gene expression databases

ArrayExpress

O97111.

Bgee

O97111.

Family and domain databases

InterPro

IPR000270. OPR_PB1.
IPR001478. PDZ/DHR/GLGF.
[Graphical view]

KO

K06093.

Pfam

PF00564. PB1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00666. PB1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

780185.

Entry information

Entry name

O97111_DROME

Accession

Primary (citable) accession number: O97111

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)