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Protein

Small ubiquitin-related modifier

Gene

smt3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: FlyBase
  • cellular response to transforming growth factor beta stimulus Source: FlyBase
  • central nervous system projection neuron axonogenesis Source: FlyBase
  • dendritic spine morphogenesis Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • lipid homeostasis Source: FlyBase
  • mitotic spindle organization Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of MAP kinase activity Source: FlyBase
  • positive regulation of MyD88-dependent toll-like receptor signaling pathway Source: FlyBase
  • positive regulation of protein localization to plasma membrane Source: FlyBase
  • positive regulation of Ras protein signal transduction Source: FlyBase
  • protein desumoylation Source: FlyBase
  • protein import into nucleus Source: FlyBase
  • protein sumoylation Source: FlyBase
  • pupariation Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • syncytial blastoderm mitotic cell cycle Source: FlyBase
  • tricarboxylic acid cycle Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-3065679. SUMO is proteolytically processed.
R-DME-3108214. SUMOylation of DNA damage response and repair proteins.
R-DME-3232118. SUMOylation of transcription factors.
R-DME-4551638. SUMOylation of chromatin organization proteins.
R-DME-4570464. SUMOylation of RNA binding proteins.
R-DME-4615885. SUMOylation of DNA replication proteins.
R-DME-5696395. Formation of Incision Complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifierUniRule annotation
Short name:
SUMOUniRule annotation
Gene namesi
Name:smt3Imported
Synonyms:Smt3Imported
ORF Names:CG4494Imported, Dmel_CG4494Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0264922. smt3.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

  • condensed chromosome outer kinetochore Source: FlyBase
  • condensed nuclear chromosome Source: FlyBase
  • condensed nuclear chromosome, centromeric region Source: FlyBase
  • midbody Source: FlyBase
  • nucleolus Source: FlyBase
  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiFBgn0026170.

Interactioni

Protein-protein interaction databases

MINTiMINT-866614.
STRINGi7227.FBpp0078984.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K1FNMR-A1-88[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 88Ubiquitin-likeInterPro annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.UniRule annotation
Contains 1 ubiquitin-like domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
KOiK12160.
OMAiLMQAYCD.
OrthoDBiEOG091G10ZQ.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiIPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O97102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEKKGGET EHINLKVLGQ DNAVVQFKIK KHTPLRKLMN AYCDRAGLSM
60 70 80 90
QVVRFRFDGQ PINENDTPTS LEMEEGDTIE VYQQQTGGAP
Length:90
Mass (Da):10,124
Last modified:May 1, 1999 - v1
Checksum:iE49DA04C24A13CA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei90Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053083 mRNA. Translation: AAD19219.1.
AF218862 mRNA. Translation: AAF31702.1.
AE014134 Genomic DNA. Translation: AAF52470.1.
AY061090 mRNA. Translation: AAL28638.1.
AE014134 Genomic DNA. Translation: ALI30198.1.
KX531939 mRNA. Translation: ANY27749.1.
RefSeqiNP_001303312.1. NM_001316383.1.
NP_477411.1. NM_058063.4.
UniGeneiDm.6873.

Genome annotation databases

EnsemblMetazoaiFBtr0079356; FBpp0078984; FBgn0264922.
FBtr0346716; FBpp0312327; FBgn0264922.
GeneIDi33981.
KEGGidme:Dmel_CG4494.
UCSCiCG4494-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053083 mRNA. Translation: AAD19219.1.
AF218862 mRNA. Translation: AAF31702.1.
AE014134 Genomic DNA. Translation: AAF52470.1.
AY061090 mRNA. Translation: AAL28638.1.
AE014134 Genomic DNA. Translation: ALI30198.1.
KX531939 mRNA. Translation: ANY27749.1.
RefSeqiNP_001303312.1. NM_001316383.1.
NP_477411.1. NM_058063.4.
UniGeneiDm.6873.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K1FNMR-A1-88[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-866614.
STRINGi7227.FBpp0078984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079356; FBpp0078984; FBgn0264922.
FBtr0346716; FBpp0312327; FBgn0264922.
GeneIDi33981.
KEGGidme:Dmel_CG4494.
UCSCiCG4494-RA. d. melanogaster.

Organism-specific databases

CTDi33981.
FlyBaseiFBgn0264922. smt3.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
KOiK12160.
OMAiLMQAYCD.
OrthoDBiEOG091G10ZQ.

Enzyme and pathway databases

ReactomeiR-DME-3065679. SUMO is proteolytically processed.
R-DME-3108214. SUMOylation of DNA damage response and repair proteins.
R-DME-3232118. SUMOylation of transcription factors.
R-DME-4551638. SUMOylation of chromatin organization proteins.
R-DME-4570464. SUMOylation of RNA binding proteins.
R-DME-4615885. SUMOylation of DNA replication proteins.
R-DME-5696395. Formation of Incision Complex in GG-NER.

Miscellaneous databases

ChiTaRSismt3. fly.
GenomeRNAii33981.

Gene expression databases

BgeeiFBgn0026170.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiIPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO97102_DROME
AccessioniPrimary (citable) accession number: O97102
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.