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Protein

Probable peptidyl-tRNA hydrolase 2

Gene

CG1307

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.By similarity

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidyl-tRNA hydrolase 2 (EC:3.1.1.29)
Short name:
PTH 2
Gene namesi
ORF Names:CG1307
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0026566. CG1307.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202821 – 186Probable peptidyl-tRNA hydrolase 2Add BLAST186

Proteomic databases

PaxDbiO97067.
PRIDEiO97067.

Expressioni

Gene expression databases

BgeeiFBgn0026566.
ExpressionAtlasiO97067. baseline.
GenevisibleiO97067. DM.

Interactioni

Protein-protein interaction databases

BioGridi66012. 18 interactors.
DIPiDIP-17218N.
IntActiO97067. 7 interactors.
STRINGi7227.FBpp0290838.

Structurei

3D structure databases

ProteinModelPortaliO97067.
SMRiO97067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family.Curated

Phylogenomic databases

eggNOGiKOG3282. Eukaryota.
COG1990. LUCA.
GeneTreeiENSGT00390000015991.
InParanoidiO97067.
KOiK04794.
OMAiQVAHGAV.
OrthoDBiEOG091G0WC2.
PhylomeDBiO97067.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.

Sequencei

Sequence statusi: Complete.

O97067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKLLDPTQ IINGLAVMLS FFVGYRYALK RGDAKDSVTE GAATPFSQES
60 70 80 90 100
SVSSGSEASV SDKGYGGLND NFKMVLVVRN DLKMGKGKIA AQCGHGAVGA
110 120 130 140 150
YQRAVVRTPR LLRSWENCGC AKIAVRVESE AELMAIKKEA ERQQLNTCLI
160 170 180
RDAGRTQIEA NSKTVLAVGP AAAADIDRVT GHLKLL
Length:186
Mass (Da):19,873
Last modified:February 28, 2003 - v2
Checksum:iF431CCF19F4D8707
GO

Sequence cautioni

The sequence AAD19814 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM52710 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001572 Genomic DNA. Translation: AAD19814.1. Sequence problems.
AE014297 Genomic DNA. Translation: AAN13366.1.
AY122198 mRNA. Translation: AAM52710.1. Different initiation.
RefSeqiNP_001287202.1. NM_001300273.1.
NP_649675.2. NM_141418.4.

Genome annotation databases

EnsemblMetazoaiFBtr0301623; FBpp0290838; FBgn0026566.
FBtr0339933; FBpp0308960; FBgn0026566.
FBtr0346140; FBpp0311968; FBgn0026566.
GeneIDi40814.
KEGGidme:Dmel_CG1307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001572 Genomic DNA. Translation: AAD19814.1. Sequence problems.
AE014297 Genomic DNA. Translation: AAN13366.1.
AY122198 mRNA. Translation: AAM52710.1. Different initiation.
RefSeqiNP_001287202.1. NM_001300273.1.
NP_649675.2. NM_141418.4.

3D structure databases

ProteinModelPortaliO97067.
SMRiO97067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66012. 18 interactors.
DIPiDIP-17218N.
IntActiO97067. 7 interactors.
STRINGi7227.FBpp0290838.

Proteomic databases

PaxDbiO97067.
PRIDEiO97067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0301623; FBpp0290838; FBgn0026566.
FBtr0339933; FBpp0308960; FBgn0026566.
FBtr0346140; FBpp0311968; FBgn0026566.
GeneIDi40814.
KEGGidme:Dmel_CG1307.

Organism-specific databases

FlyBaseiFBgn0026566. CG1307.

Phylogenomic databases

eggNOGiKOG3282. Eukaryota.
COG1990. LUCA.
GeneTreeiENSGT00390000015991.
InParanoidiO97067.
KOiK04794.
OMAiQVAHGAV.
OrthoDBiEOG091G0WC2.
PhylomeDBiO97067.

Miscellaneous databases

GenomeRNAii40814.
PROiO97067.

Gene expression databases

BgeeiFBgn0026566.
ExpressionAtlasiO97067. baseline.
GenevisibleiO97067. DM.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTH2_DROME
AccessioniPrimary (citable) accession number: O97067
Secondary accession number(s): Q8MR09, Q9VI42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 28, 2003
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.