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Protein
Submitted name:

Metabotropic glutamate GABA-like receptor

Gene

mgrl

Organism
Geodia cydonium (Sponge)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Metabotropic glutamate GABA-like receptorImported
Gene namesi
Name:mgrlImported
OrganismiGeodia cydonium (Sponge)Imported
Taxonomic identifieri6047 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHeteroscleromorphaTetractinellidaAstrophorinaGeodiidaeGeodia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei139 – 16224HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19522HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23420HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27622HelicalSequence analysisAdd
BLAST
Transmembranei318 – 34326HelicalSequence analysisAdd
BLAST
Transmembranei355 – 37723HelicalSequence analysisAdd
BLAST
Transmembranei383 – 40523HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 416280G_PROTEIN_RECEP_F3_4InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
IPR002457. GPCR_3_GABA_rcpt_B2.
IPR028082. Peripla_BP_I.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PTHR10519:SF40. PTHR10519:SF40. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O96954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAFAFALNK TFNDLKQQSA SGSGNLMEDS ITLTTKNSVF VERMFQHLQN
60 70 80 90 100
TSFAGLSGKT VQFDEDGIRE INVLDMVQYQ WNNSEIDRVI VGEIRVEESL
110 120 130 140 150
VTHYLPPFSH ENPGMWPDGI PNDGIPIENV VTVSVPLTVV YVALAVGGLV
160 170 180 190 200
FAIVCVFFTV IFRKRKLIRL SSPNLNYLIG LGAIILYFNV ITLVIPTTDT
210 220 230 240 250
VIAAILCNIN PWLTSLGYSL CYGTILAKTI RIWFIFNKPR VPSVTKSIVI
260 270 280 290 300
KDYALALFVV SLVVIDVIIL GIFAIVEGLR GELAVHRTSN KENIEDTIGP
310 320 330 340 350
TCEFHQYYLY ICKSKGQVAL FTVLFGYKGL LQVTALILAF NTRKVKVKGL
360 370 380 390 400
DDSKYIAAAI YVTSIVLAVA AISTYTLRDY VNIYPAVVGI GFLLGTTMIL
410 420 430 440 450
GLVFVPRMVG LYQDPQGDNI KISNSHGSHD VPRRDSAYSP DAEIRRLKQR
460 470 480 490 500
ISELEKNIQP SQMFPMGTTV SVSNPDYMAS SPSAAERYQN HQLHICASSH
510 520
DSTRDNPLTD TKRNVVRWSD DHSPQTPL
Length:528
Mass (Da):58,642
Last modified:May 1, 1999 - v1
Checksum:i0B99D8357FEAB3B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17211 mRNA. Translation: CAA76688.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17211 mRNA. Translation: CAA76688.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
IPR002457. GPCR_3_GABA_rcpt_B2.
IPR028082. Peripla_BP_I.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PTHR10519:SF40. PTHR10519:SF40. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Origin of neuronal-like receptors in Metazoa: cloning of a metabotropic glutamate/GABA-like receptor from the marine sponge Geodia cydonium."
    Perovic S., Krasko A., Prokic I., Muller I.M., Muller W.E.
    Cell Tissue Res. 296:395-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO96954_GEOCY
AccessioniPrimary (citable) accession number: O96954
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.