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Protein

Dynein light chain 2, cytoplasmic

Gene

Cdlc2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a non-catalytic accessory component of a dynein complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-6798695. Neutrophil degranulation.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Gene namesi
Name:Cdlc2
ORF Names:CG5450
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0026141. Cdlc2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoplasmic dynein complex Source: GO_Central
  • dynein complex Source: FlyBase
  • microtubule Source: UniProtKB-KW
  • myosin complex Source: GO_Central

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951351 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

PaxDbiO96860.
PRIDEiO96860.

Expressioni

Gene expression databases

BgeeiFBgn0026141.
ExpressionAtlasiO96860. differential.
GenevisibleiO96860. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi59568. 41 interactors.
DIPiDIP-17518N.
IntActiO96860. 12 interactors.
MINTiMINT-281035.
STRINGi7227.FBpp0077590.

Structurei

3D structure databases

ProteinModelPortaliO96860.
SMRiO96860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
InParanoidiO96860.
KOiK10418.
OMAiQAIMSDR.
OrthoDBiEOG091G15JY.
PhylomeDBiO96860.

Family and domain databases

InterProiView protein in InterPro
IPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiView protein in Pfam
PF01221. Dynein_light. 1 hit.
SMARTiView protein in SMART
SM01375. Dynein_light. 1 hit.
PROSITEiView protein in PROSITE
PS01239. DYNEIN_LIGHT_1. 1 hit.

Sequencei

Sequence statusi: Complete.

O96860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA FIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,358
Last modified:May 1, 1999 - v1
Checksum:i538C7661E0423A8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48847 mRNA. Translation: AAD00073.1.
AE014134 Genomic DNA. Translation: AAF51383.1.
AE014134 Genomic DNA. Translation: AAN10465.1.
AY069718 mRNA. Translation: AAL39863.1.
BT088986 mRNA. Translation: ACT88127.1.
RefSeqiNP_001245836.1. NM_001258907.2.
NP_477408.1. NM_058060.4.
NP_722698.1. NM_164412.2.
UniGeneiDm.1988.

Genome annotation databases

EnsemblMetazoaiFBtr0077924; FBpp0077590; FBgn0026141.
FBtr0077925; FBpp0077591; FBgn0026141.
FBtr0305553; FBpp0294004; FBgn0026141.
GeneIDi33319.
KEGGidme:Dmel_CG5450.

Similar proteinsi

Entry informationi

Entry nameiDYL2_DROME
AccessioniPrimary (citable) accession number: O96860
Secondary accession number(s): A4UZY5, C6SUZ4, Q541G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families