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Protein

Dynein light chain 2, cytoplasmic

Gene

Cdlc2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a non-catalytic accessory component of a dynein complex.By similarity

GO - Molecular functioni

  • ATPase activity, coupled Source: FlyBase
  • motor activity Source: UniProtKB-KW

GO - Biological processi

  • microtubule-based movement Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Gene namesi
Name:Cdlc2
ORF Names:CG5450
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0026141. Cdlc2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • dynein complex Source: FlyBase
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951351 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

PaxDbiO96860.
PRIDEiO96860.

Expressioni

Gene expression databases

BgeeiFBgn0026141.
ExpressionAtlasiO96860. baseline.
GenevisibleiO96860. DM.

Interactioni

Protein-protein interaction databases

BioGridi59568. 41 interactors.
DIPiDIP-17518N.
IntActiO96860. 12 interactors.
MINTiMINT-281035.
STRINGi7227.FBpp0077590.

Structurei

3D structure databases

ProteinModelPortaliO96860.
SMRiO96860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
InParanoidiO96860.
KOiK10418.
OMAiAIECATQ.
OrthoDBiEOG091G15JY.
PhylomeDBiO96860.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O96860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA FIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,358
Last modified:May 1, 1999 - v1
Checksum:i538C7661E0423A8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48847 mRNA. Translation: AAD00073.1.
AE014134 Genomic DNA. Translation: AAF51383.1.
AE014134 Genomic DNA. Translation: AAN10465.1.
AY069718 mRNA. Translation: AAL39863.1.
BT088986 mRNA. Translation: ACT88127.1.
RefSeqiNP_001245836.1. NM_001258907.2.
NP_477408.1. NM_058060.4.
NP_722698.1. NM_164412.2.
UniGeneiDm.1988.

Genome annotation databases

EnsemblMetazoaiFBtr0077924; FBpp0077590; FBgn0026141.
FBtr0077925; FBpp0077591; FBgn0026141.
FBtr0305553; FBpp0294004; FBgn0026141.
GeneIDi33319.
KEGGidme:Dmel_CG5450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48847 mRNA. Translation: AAD00073.1.
AE014134 Genomic DNA. Translation: AAF51383.1.
AE014134 Genomic DNA. Translation: AAN10465.1.
AY069718 mRNA. Translation: AAL39863.1.
BT088986 mRNA. Translation: ACT88127.1.
RefSeqiNP_001245836.1. NM_001258907.2.
NP_477408.1. NM_058060.4.
NP_722698.1. NM_164412.2.
UniGeneiDm.1988.

3D structure databases

ProteinModelPortaliO96860.
SMRiO96860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59568. 41 interactors.
DIPiDIP-17518N.
IntActiO96860. 12 interactors.
MINTiMINT-281035.
STRINGi7227.FBpp0077590.

Proteomic databases

PaxDbiO96860.
PRIDEiO96860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077924; FBpp0077590; FBgn0026141.
FBtr0077925; FBpp0077591; FBgn0026141.
FBtr0305553; FBpp0294004; FBgn0026141.
GeneIDi33319.
KEGGidme:Dmel_CG5450.

Organism-specific databases

CTDi33319.
FlyBaseiFBgn0026141. Cdlc2.

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
InParanoidiO96860.
KOiK10418.
OMAiAIECATQ.
OrthoDBiEOG091G15JY.
PhylomeDBiO96860.

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

GenomeRNAii33319.
PROiO96860.

Gene expression databases

BgeeiFBgn0026141.
ExpressionAtlasiO96860. baseline.
GenevisibleiO96860. DM.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYL2_DROME
AccessioniPrimary (citable) accession number: O96860
Secondary accession number(s): A4UZY5, C6SUZ4, Q541G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.