O96833 (O96833_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
EG:23E12.2 protein EMBL CAA21413.1

Gene names

Name:	RhoGAP1A FlyBase FBgn0025836
Synonyms:	EG:23E12.2 EMBL CAA21413.1
ORF Names:	CG40494 FlyBase FBgn0025836

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	658 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS000219 Contains 1 PH domain. SAAS SAAS000198 Contains 1 Rho-GAP domain. SAAS SAAS000198

Ontologies

Keywords
Molecular function	GTPase activation SAAS SAAS000198
Gene Ontology (GO)
Biological process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O96833 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 5675FC5D1A8E1A14	FASTA	658	75,067
	10 20 30 40 50 60 MQYKKAIHAT LTTSQPVIRE EEENTIFFKI DELYDLHTGF LSDLKTIVSH EGGDVLIGEP 70 80 90 100 110 120 FRRLAEMFDL YSAFLHNYKN AIETVKKCSA NNPQFKKIVS TIVLNLQTEQ SLTLEDLLHK 130 140 150 160 170 180 PVARVQINAL VFNDLLRETP NAHPDHQPLR QAQKIIQMFL NQFNVVNQRL PIESNRNLRR 190 200 210 220 230 240 MVRNSFIVEL VDGHRKLRHL FLFNDVIACA KYKALGRDRI DYELKWFIPL KDVSIYEEAD 250 260 270 280 290 300 PAVELKESSP ANISQVKRNL RSVRDQLAME VANSGSGGFR SGDKYRRKLA DLESQLVLAT 310 320 330 340 350 360 PNLVLRLGNK ANNKTITFFL SSDFERTQWI DSILSLKQKC NLPGANTINS LEVTAFIVAM 370 380 390 400 410 420 QKGMKTEMGS YLMRNTNDES LLVGDLYMGV HGLEGLEQAN DLYICVEVDS YGHYFRKATT 430 440 450 460 470 480 KKICRSQTPL WNESFMLELE GSQNVRILLY EAKERPLLKA KHILKVGVKS ACIREVERRG 490 500 510 520 530 540 MLEVGCYRVS GSASDLAKLK KAFESGEYMA LMDAYEAEQL LREVDIHSVT GILKTFLREL 550 560 570 580 590 600 PEALFTDQLY PRFFDTFSAF SNNNESTRIN ELLKVFEELP QANKASITSI LDHLIRVHEK 610 620 630 640 650 ETDNKMSLHN LAMVFGPTLL RPGQTQVKQK DPLAASTVDV MAQAGILYCF LQARIKKD

References

[1]	"Sequencing the distal X chromosome of Drosophila melanogaster." Madueno E., de Pablos B., Modolell J. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Benos P. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL031884 Genomic DNA. Translation: CAA21413.1.
3D structure databases
HSSP	HSSP built from PDB template 1F7C based on UniProtKB Q98935.
ProteinModelPortal	O96833.
SMR	O96833. Positions 3-164, 173-239, 383-653.
ModBase	Search...
Protein-protein interaction databases
STRING	O96833.
Proteomic databases
PRIDE	O96833.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0025836. RhoGAP1A.
Phylogenomic databases
InParanoid	O96833.
OrthoDB	EOG4PZGNH.
Gene expression databases
ArrayExpress	O96833.
Bgee	O96833.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR000219. DH-domain. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 2 hits. G3DSA:1.10.555.10. RhoGAP. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit.
Pfam	PF00168. C2. 1 hit. PF00620. RhoGAP. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00233. PH. 1 hit. SM00324. RhoGAP. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF48065. DH-domain. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O96833_DROME

Accession

Primary (citable) accession number: O96833

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	July 27, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)