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Protein

Probable elongation factor 1-beta

Gene

eEF1beta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

GO - Molecular functioni

  • translation elongation factor activity Source: FlyBase

GO - Biological processi

  • translational elongation Source: FlyBase

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongation factor 1-beta
Short name:
EF-1-beta
Gene namesi
Name:eEF1betaImported
ORF Names:CG6341Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0028737 eEF1beta

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001550452 – 222Probable elongation factor 1-betaAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO96827
PRIDEiO96827

PTM databases

iPTMnetiO96827

Expressioni

Gene expression databases

BgeeiFBgn0028737
ExpressionAtlasiO96827 baseline and differential
GenevisibleiO96827 DM

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, beta' and gamma.

Protein-protein interaction databases

BioGridi69539, 9 interactors
DIPiDIP-20265N
IntActiO96827, 15 interactors
STRINGi7227.FBpp0305165

Structurei

3D structure databases

ProteinModelPortaliO96827
SMRiO96827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGiKOG1668 Eukaryota
COG2092 LUCA
GeneTreeiENSGT00390000011747
InParanoidiO96827
KOiK03232
OMAiPSQADVH
OrthoDBiEOG091G0P0Z
PhylomeDBiO96827

Family and domain databases

CDDicd00292 EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR036282 Glutathione-S-Trfase_C_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF54984 SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFGDVTTPQ GLKELNAFLA DNSYISGYTP SKADLSVFDA LGKAPSADNV
60 70 80 90 100
NVARWYRHIA SFEAAERAAW SGTPLPQLAG GKPTVAAAAK PAADDDDDVD
110 120 130 140 150
LFGSDDEEDE EAERIKQERV AAYAAKKSKK PALIAKSSVL LDVKPWDDET
160 170 180 190 200
DMKEMENNVR TIEMDGLLWG ASKLVPVGYG INKLQIMCVI EDDKVSIDLL
210 220
QEKIEEFEDF VQSVDIAAFN KI
Length:222
Mass (Da):24,247
Last modified:January 23, 2007 - v3
Checksum:i3218C4606FC44AB4
GO

Sequence cautioni

The sequence AAD46929 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57941.3
AL031863 Genomic DNA Translation: CAA21314.1
AF172636 mRNA Translation: AAD46929.2 Different initiation.
PIRiT13689
RefSeqiNP_001286506.1, NM_001299577.1
NP_524808.3, NM_080069.4
UniGeneiDm.1807

Genome annotation databases

EnsemblMetazoaiFBtr0332947; FBpp0305165; FBgn0028737
FBtr0345627; FBpp0311691; FBgn0028737
GeneIDi45249
KEGGidme:Dmel_CG6341

Similar proteinsi

Entry informationi

Entry nameiEF1B_DROME
AccessioniPrimary (citable) accession number: O96827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health