Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable elongation factor 1-beta

Gene

Ef1beta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: FlyBase
  • translation elongation factor activity Source: FlyBase

GO - Biological processi

  • translational elongation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongation factor 1-beta
Short name:
EF-1-beta
Gene namesi
Name:Ef1beta
ORF Names:CG6341
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0028737. Ef1beta.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: FlyBase
  • eukaryotic translation elongation factor 1 complex Source: FlyBase
  • lipid particle Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 222221Probable elongation factor 1-betaPRO_0000155045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO96827.
PRIDEiO96827.

PTM databases

iPTMnetiO96827.

Expressioni

Gene expression databases

BgeeiFBgn0028737.
GenevisibleiO96827. DM.

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, beta' and gamma.

Protein-protein interaction databases

BioGridi69539. 8 interactions.
DIPiDIP-20265N.
IntActiO96827. 15 interactions.
MINTiMINT-321736.
STRINGi7227.FBpp0305165.

Structurei

3D structure databases

ProteinModelPortaliO96827.
SMRiO96827. Positions 133-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGiKOG1668. Eukaryota.
COG2092. LUCA.
GeneTreeiENSGT00390000011747.
InParanoidiO96827.
KOiK03232.
OMAiMEKNVRT.
OrthoDBiEOG091G0P0Z.
PhylomeDBiO96827.

Family and domain databases

CDDicd00292. EF1B. 1 hit.
Gene3Di1.20.1050.10. 1 hit.
3.30.70.60. 1 hit.
InterProiIPR018940. EF-1_beta_acid_region_euk.
IPR014038. EF1B_bsu/dsu_GNE.
IPR010987. Glutathione-S-Trfase_C-like.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
IPR001326. Transl_elong_EF1B_B/D_CS.
[Graphical view]
PfamiPF10587. EF-1_beta_acid. 1 hit.
PF00736. EF1_GNE. 1 hit.
[Graphical view]
SMARTiSM01182. EF-1_beta_acid. 1 hit.
SM00888. EF1_GNE. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF54984. SSF54984. 1 hit.
PROSITEiPS00824. EF1BD_1. 1 hit.
PS00825. EF1BD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFGDVTTPQ GLKELNAFLA DNSYISGYTP SKADLSVFDA LGKAPSADNV
60 70 80 90 100
NVARWYRHIA SFEAAERAAW SGTPLPQLAG GKPTVAAAAK PAADDDDDVD
110 120 130 140 150
LFGSDDEEDE EAERIKQERV AAYAAKKSKK PALIAKSSVL LDVKPWDDET
160 170 180 190 200
DMKEMENNVR TIEMDGLLWG ASKLVPVGYG INKLQIMCVI EDDKVSIDLL
210 220
QEKIEEFEDF VQSVDIAAFN KI
Length:222
Mass (Da):24,247
Last modified:January 23, 2007 - v3
Checksum:i3218C4606FC44AB4
GO

Sequence cautioni

The sequence AAD46929 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57941.3.
AL031863 Genomic DNA. Translation: CAA21314.1.
AF172636 mRNA. Translation: AAD46929.2. Different initiation.
PIRiT13689.
RefSeqiNP_001286506.1. NM_001299577.1.
NP_524808.3. NM_080069.4.
UniGeneiDm.1807.

Genome annotation databases

EnsemblMetazoaiFBtr0332947; FBpp0305165; FBgn0028737.
FBtr0345627; FBpp0311691; FBgn0028737.
GeneIDi45249.
KEGGidme:Dmel_CG6341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57941.3.
AL031863 Genomic DNA. Translation: CAA21314.1.
AF172636 mRNA. Translation: AAD46929.2. Different initiation.
PIRiT13689.
RefSeqiNP_001286506.1. NM_001299577.1.
NP_524808.3. NM_080069.4.
UniGeneiDm.1807.

3D structure databases

ProteinModelPortaliO96827.
SMRiO96827. Positions 133-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69539. 8 interactions.
DIPiDIP-20265N.
IntActiO96827. 15 interactions.
MINTiMINT-321736.
STRINGi7227.FBpp0305165.

PTM databases

iPTMnetiO96827.

Proteomic databases

PaxDbiO96827.
PRIDEiO96827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0332947; FBpp0305165; FBgn0028737.
FBtr0345627; FBpp0311691; FBgn0028737.
GeneIDi45249.
KEGGidme:Dmel_CG6341.

Organism-specific databases

CTDi45249.
FlyBaseiFBgn0028737. Ef1beta.

Phylogenomic databases

eggNOGiKOG1668. Eukaryota.
COG2092. LUCA.
GeneTreeiENSGT00390000011747.
InParanoidiO96827.
KOiK03232.
OMAiMEKNVRT.
OrthoDBiEOG091G0P0Z.
PhylomeDBiO96827.

Miscellaneous databases

ChiTaRSiEf1beta. fly.
GenomeRNAii45249.
PROiO96827.

Gene expression databases

BgeeiFBgn0028737.
GenevisibleiO96827. DM.

Family and domain databases

CDDicd00292. EF1B. 1 hit.
Gene3Di1.20.1050.10. 1 hit.
3.30.70.60. 1 hit.
InterProiIPR018940. EF-1_beta_acid_region_euk.
IPR014038. EF1B_bsu/dsu_GNE.
IPR010987. Glutathione-S-Trfase_C-like.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
IPR001326. Transl_elong_EF1B_B/D_CS.
[Graphical view]
PfamiPF10587. EF-1_beta_acid. 1 hit.
PF00736. EF1_GNE. 1 hit.
[Graphical view]
SMARTiSM01182. EF-1_beta_acid. 1 hit.
SM00888. EF1_GNE. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF54984. SSF54984. 1 hit.
PROSITEiPS00824. EF1BD_1. 1 hit.
PS00825. EF1BD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEF1B_DROME
AccessioniPrimary (citable) accession number: O96827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.