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Protein

Probable elongation factor 1-beta

Gene

eEF1beta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

GO - Molecular functioni

  • translation elongation factor activity Source: FlyBase

GO - Biological processi

  • translational elongation Source: FlyBase

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongation factor 1-beta
Short name:
EF-1-beta
Gene namesi
Name:eEF1betaImported
ORF Names:CG6341Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0028737. eEF1beta.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001550452 – 222Probable elongation factor 1-betaAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO96827.
PRIDEiO96827.

PTM databases

iPTMnetiO96827.

Expressioni

Gene expression databases

BgeeiFBgn0028737.
ExpressionAtlasiO96827. differential.
GenevisibleiO96827. DM.

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, beta' and gamma.

Protein-protein interaction databases

BioGridi69539. 9 interactors.
DIPiDIP-20265N.
IntActiO96827. 15 interactors.
MINTiMINT-321736.
STRINGi7227.FBpp0305165.

Structurei

3D structure databases

ProteinModelPortaliO96827.
SMRiO96827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGiKOG1668. Eukaryota.
COG2092. LUCA.
GeneTreeiENSGT00390000011747.
InParanoidiO96827.
KOiK03232.
OMAiPSQADVH.
OrthoDBiEOG091G0P0Z.
PhylomeDBiO96827.

Family and domain databases

CDDicd00292. EF1B. 1 hit.
Gene3Di3.30.70.60. 1 hit.
InterProiView protein in InterPro
IPR036219. eEF-1beta-like_sf.
IPR018940. EF-1_beta_acid_region_euk.
IPR014038. EF1B_bsu/dsu_GNE.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
IPR001326. Transl_elong_EF1B_B/D_CS.
PfamiView protein in Pfam
PF10587. EF-1_beta_acid. 1 hit.
PF00736. EF1_GNE. 1 hit.
SMARTiView protein in SMART
SM01182. EF-1_beta_acid. 1 hit.
SM00888. EF1_GNE. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF54984. SSF54984. 1 hit.
PROSITEiView protein in PROSITE
PS00824. EF1BD_1. 1 hit.
PS00825. EF1BD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFGDVTTPQ GLKELNAFLA DNSYISGYTP SKADLSVFDA LGKAPSADNV
60 70 80 90 100
NVARWYRHIA SFEAAERAAW SGTPLPQLAG GKPTVAAAAK PAADDDDDVD
110 120 130 140 150
LFGSDDEEDE EAERIKQERV AAYAAKKSKK PALIAKSSVL LDVKPWDDET
160 170 180 190 200
DMKEMENNVR TIEMDGLLWG ASKLVPVGYG INKLQIMCVI EDDKVSIDLL
210 220
QEKIEEFEDF VQSVDIAAFN KI
Length:222
Mass (Da):24,247
Last modified:January 23, 2007 - v3
Checksum:i3218C4606FC44AB4
GO

Sequence cautioni

O96827: The sequence AAD46929 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57941.3.
AL031863 Genomic DNA. Translation: CAA21314.1.
AF172636 mRNA. Translation: AAD46929.2. Different initiation.
PIRiT13689.
RefSeqiNP_001286506.1. NM_001299577.1.
NP_524808.3. NM_080069.4.
UniGeneiDm.1807.

Genome annotation databases

EnsemblMetazoaiFBtr0332947; FBpp0305165; FBgn0028737.
FBtr0345627; FBpp0311691; FBgn0028737.
GeneIDi45249.
KEGGidme:Dmel_CG6341.

Similar proteinsi

Entry informationi

Entry nameiEF1B_DROME
AccessioniPrimary (citable) accession number: O96827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families