ID   CDC2H_PLAKH             Reviewed;         288 AA.
AC   O96821;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Cell division control protein 2 homolog;
DE            EC=2.7.11.22;
DE            EC=2.7.11.23;
GN   Name=CRK2;
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=99020256; PubMed=9803415; DOI=10.1016/S0166-6851(98)00104-2;
RA   Vinkenoog R., Speranca M.A., Ramesar J., Thomas A.W.,
RA   del Portillo H.A., Janse C.J., Waters A.P.;
RT   "Characterisation of the Cdc2-related kinase 2 gene from Plasmodium
RT   knowlesi and P. berghei.";
RL   Mol. Biochem. Parasitol. 95:229-240(1998).
CC   -!- FUNCTION: Plays a key role in the control of the eukaryotic cell
CC       cycle. It is required in higher cells for entry into S-phase and
CC       mitosis. Component of the kinase complex that phosphorylates the
CC       repetitive C-terminus of RNA polymerase II (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- CATALYTIC ACTIVITY: ATP + [DNA-directed RNA polymerase] = ADP +
CC       [DNA-directed RNA polymerase] phosphate.
CC   -!- ENZYME REGULATION: Phosphorylation at Thr-14 or Tyr-15 inactivates
CC       the enzyme, while phosphorylation at Thr-158 activates it (By
CC       similarity).
CC   -!- SUBUNIT: Forms a stable but non-covalent complex with a regulatory
CC       subunit and with a cyclin (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. CDC2/CDKX subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AJ224155; CAA11852.1; -; Genomic_DNA.
DR   RefSeq; XP_002261323.1; -.
DR   HSSP; Q07785; 1OB3.
DR   SMR; O96821; 1-286.
DR   GeneID; 7321824; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
DR   GO; GO:0008353; F:RNA polymerase subunit kinase activity; IEA:EC.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    288       Cell division control protein 2 homolog.
FT                                /FTId=PRO_0000232670.
FT   DOMAIN        4    284       Protein kinase.
FT   NP_BIND      10     18       ATP (By similarity).
FT   ACT_SITE    125    125       Proton acceptor (By similarity).
FT   BINDING      32     32       ATP (By similarity).
FT   MOD_RES      14     14       Phosphothreonine (By similarity).
FT   MOD_RES      15     15       Phosphotyrosine (By similarity).
FT   MOD_RES     158    158       Phosphothreonine; by CAK (By similarity).
SQ   SEQUENCE   288 AA;  32946 MW;  02B0F83D5187AC68 CRC64;
     MEKYHGLEKI GEGTYGVVYK AQNNYGETFA LKKIRLEKED EGIPSTAIRE ISILKELKHS
     NIVKLYDVIH TKKRLILVFE HLDQDLKKLL DVCDGGLESV TAKSFLLQLL SGIAYCHEHR
     VLHRDLKPQN LLINREGELK IADFGLARAF GIPVRKYTHE VVTLWYRAPD ILMGSKKYST
     PIDIWSVGCI FAEMVNGRPL FPGVSETDQL MRIFRILGTP NSANWPSVTE LPKYDPDFIV
     YEPLPWETFL KGLDDTGIDL LSKMLRLDPN QRITAKEALQ HAYFKESS
//