Reviewed,
UniProtKB/Swiss-Prot O96821 (CDC2H_PLAKH)
Last modified
June 16, 2009.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division control protein 2 homolog EC=2.7.11.22 EC=2.7.11.23 | ||
| Gene names |
| ||
| Organism | Plasmodium knowlesi (strain H) | ||
| Taxonomic identifier | 5851 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Plasmodium) |
Protein attributes
| Sequence length | 288 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. |
| Enzyme regulation | Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity. |
| Subunit structure | Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase subunit kinase activityInferred from electronic annotation. Source: EC cyclin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 288 | 288 | Cell division control protein 2 homolog | PRO_0000232670 | |||||
Regions | |||||||||
| Domain | 4 – 284 | 281 | Protein kinase | ||||||
| Nucleotide binding | 10 – 18 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 125 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 32 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 14 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 15 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 158 | 1 | Phosphothreonine; by CAK By similarity | ||||||
Sequences
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References
| [1] | "Characterisation of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei." Vinkenoog R., Speranca M.A., Ramesar J., Thomas A.W., del Portillo H.A., Janse C.J., Waters A.P. Mol. Biochem. Parasitol. 95:229-240(1998) [PubMed: 9803415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AJ224155 Genomic DNA. Translation: CAA11852.1. | |
| RefSeq | XP_002261323.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OB3 based on UniProtKB Q07785. |
| SMR | O96821. Positions 1-286. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 7321824. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDC2H_PLAKH | ||||||||
| Accession | Primary (citable) accession number: O96821 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

Clusters with


