ID   TPM_CHIKI               Reviewed;         285 AA.
AC   O96764;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 2.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Tropomyosin {ECO:0000303|PubMed:15013982};
DE   AltName: Full=Allergen Chi k 10 {ECO:0000303|PubMed:15013982};
DE   AltName: Allergen=Chi k 10.0101 {ECO:0000305};
OS   Chironomus kiiensis (Midge).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Chironominae; Chironomus.
OX   NCBI_TaxID=84408;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=15013982; DOI=10.1128/cdli.11.2.320-324.2004;
RA   Jeong K.Y., Yum H.Y., Lee I.Y., Ree H.I., Hong C.S., Kim D.S., Yong T.S.;
RT   "Molecular cloning and characterization of tropomyosin, a major allergen of
RT   Chironomus kiiensis, a dominant species of nonbiting midges in Korea.";
RL   Clin. Diagn. Lab. Immunol. 11:320-324(2004).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction. {ECO:0000250|UniProtKB:Q22866}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:A2V735}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity. {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 81% of
CC       the 21 patients tested allergic to adult non-biting midge C.kiiensis.
CC       {ECO:0000269|PubMed:15013982}.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; AJ012184; CAA09938.2; -; mRNA.
DR   AlphaFoldDB; O96764; -.
DR   SMR; O96764; -.
DR   Allergome; 200; Chi k 10.
DR   Allergome; 3191; Chi k 10.0101.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006937; P:regulation of muscle contraction; ISS:UniProtKB.
DR   Gene3D; 1.20.5.170; -; 2.
DR   Gene3D; 1.20.5.340; -; 1.
DR   InterPro; IPR000533; Tropomyosin.
DR   PANTHER; PTHR19269; TROPOMYOSIN; 1.
DR   PANTHER; PTHR19269:SF45; TROPOMYOSIN-1, ISOFORMS 33_34; 1.
DR   Pfam; PF00261; Tropomyosin; 2.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   SUPFAM; SSF57997; Tropomyosin; 1.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Muscle protein; Repeat.
FT   CHAIN           1..285
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205683"
FT   COILED          1..273
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   285 AA;  32533 MW;  DCA3FE9C05809FF4 CRC64;
     MDAIKKKMQA MKLEKDNALD RALLCENQAR DANLRAEKAE EEARTLQKKI QTIENDLDQT
     QGQETLVNGK LEGKEKALQN AESEVAALNR RIQLLGEDLD RSEERLASAT AKLSEASAAA
     DESERARKIL ENRSLADEER MDALENQLKE ARFLAEEADK KYDEVARKLA MVEADLERAE
     ERAEAGEAKI VELEEELRVV GNNLKSLEVS EEKANQREEE YKNQIKTLTT RLKEAEARAE
     FAERSVQKLQ KEVDRLEDEL VSEKEKYREI GDDLDTAFVE LILKE
//