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Protein

Tropomyosin

Gene
N/A
Organism
Chironomus kiiensis (Midge)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Allergen: Chi k 10
OrganismiChironomus kiiensis (Midge)
Taxonomic identifieri84408 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraChironomoideaChironomidaeChironominaeChironomus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei200. Chi k 10.
3191. Chi k 10.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285TropomyosinPRO_0000205683Add
BLAST

Proteomic databases

PRIDEiO96764.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO96764.
SMRiO96764. Positions 1-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 285285By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O96764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIKKKMQA MKLEKDNALD RALLCENQAR DANLRAEKAE EEARTLQKKI
60 70 80 90 100
QTIENDLDQT QGQETLVNGK LEGKEKALQN AESEVAALNR RIQLLGEDLD
110 120 130 140 150
RSEERLASAT AKLSEASAAA DESERARKIL ENRSLADEER MDALENQLKE
160 170 180 190 200
ARFLAEEADK KYDEVARKLA MVEADLERAE ERAEAGEAKI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKANQREEE YKNQIKTLTT RLKEAEARAE FAERSVQKLQ
260 270 280
KEVDRLEDEL VSEKEKYREI GDDLDTAFVE LILKE
Length:285
Mass (Da):32,533
Last modified:September 30, 2000 - v2
Checksum:iDCA3FE9C05809FF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012184 mRNA. Translation: CAA09938.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012184 mRNA. Translation: CAA09938.2.

3D structure databases

ProteinModelPortaliO96764.
SMRiO96764. Positions 1-281.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei200. Chi k 10.
3191. Chi k 10.0101.

Proteomic databases

PRIDEiO96764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of Chironomus kiiensis tropomyosin gene."
    Yong T.S.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTPM_CHIKI
AccessioniPrimary (citable) accession number: O96764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2004
Last sequence update: September 30, 2000
Last modified: September 30, 2014
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.