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O96764 (TPM_CHIKI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 28, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin
Alternative name(s):
Allergen=Chi k 10
OrganismChironomus kiiensis (Midge)
Taxonomic identifier84408 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraChironomoideaChironomidaeChironominaeChironomus

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Subunit structure

Homodimer By similarity.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   DiseaseAllergen
   DomainCoiled coil
Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Tropomyosin
PRO_0000205683

Regions

Coiled coil1 – 285285 By similarity

Sequences

Sequence LengthMass (Da)Tools
O96764 [UniParc].

Last modified October 1, 2000. Version 2.
Checksum: DCA3FE9C05809FF4

FASTA28532,533
        10         20         30         40         50         60 
MDAIKKKMQA MKLEKDNALD RALLCENQAR DANLRAEKAE EEARTLQKKI QTIENDLDQT 

        70         80         90        100        110        120 
QGQETLVNGK LEGKEKALQN AESEVAALNR RIQLLGEDLD RSEERLASAT AKLSEASAAA 

       130        140        150        160        170        180 
DESERARKIL ENRSLADEER MDALENQLKE ARFLAEEADK KYDEVARKLA MVEADLERAE 

       190        200        210        220        230        240 
ERAEAGEAKI VELEEELRVV GNNLKSLEVS EEKANQREEE YKNQIKTLTT RLKEAEARAE 

       250        260        270        280 
FAERSVQKLQ KEVDRLEDEL VSEKEKYREI GDDLDTAFVE LILKE 

« Hide

References

[1]"Cloning of Chironomus kiiensis tropomyosin gene."
Yong T.S.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ012184 mRNA. Translation: CAA09938.2.

3D structure databases

ProteinModelPortalO96764.
SMRO96764. Positions 1-281.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome200. Chi k 10.
3191. Chi k 10.0101.

Proteomic databases

PRIDEO96764.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM_CHIKI
AccessionPrimary (citable) accession number: O96764
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2000
Last modified: November 28, 2012
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries