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O96720

- KITH_ENCCU

UniProt

O96720 - KITH_ENCCU

Protein

Thymidine kinase

Gene

TK

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 3 (29 May 2013)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei107 – 1071Proton acceptorSequence Analysis
    Binding sitei139 – 1391Substrate; via amide nitrogenBy similarity
    Metal bindingi164 – 1641ZincBy similarity
    Metal bindingi167 – 1671ZincBy similarity
    Metal bindingi203 – 2031ZincBy similarity
    Metal bindingi206 – 2061ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 388ATPSequence Analysis
    Nucleotide bindingi63 – 653ATPBy similarity
    Nucleotide bindingi106 – 1094ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    Ordered Locus Names:ECU01_0740i
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome I

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU01_0740i.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Thymidine kinasePRO_0000174951Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU01_0740i.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076391.
    KOiK00857.
    OrthoDBiEOG7Z3FGM.

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O96720-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLAVLEWKS IKRRNAPTAE MTRGTLNFVT SPMNAGKTAN MLLRARHAAT    50
    LGRRVLLAKP LSDTRHESSV IRSRCGIEMK CDLCAGPEFS FTKDVLYGDV 100
    DILLVDEAQF LSSRQIDELR EVADVHGIPV WCYGLLTDFK KNLFEGSKRL 150
    VELCDKMIEL DIVCYFCKAD GRFHLKYANG KAVVEGPSID ISIPGDGKFV 200
    AVCHMCWTEK TSTSEEVQDP RVLCAKVIPV DR 232
    Length:232
    Mass (Da):25,958
    Last modified:May 29, 2013 - v3
    Checksum:i3017360E71AF9BBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391737 Genomic DNA. Translation: CAD24944.2.
    AJ006824 Genomic DNA. Translation: CAA07261.1.
    RefSeqiXP_965909.1. XM_960816.1.

    Genome annotation databases

    GeneIDi860249.
    KEGGiecu:ECU01_0740i.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391737 Genomic DNA. Translation: CAD24944.2 .
    AJ006824 Genomic DNA. Translation: CAA07261.1 .
    RefSeqi XP_965909.1. XM_960816.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU01_0740i.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 860249.
    KEGGi ecu:ECU01_0740i.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU01_0740i.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076391.
    KOi K00857.
    OrthoDBi EOG7Z3FGM.

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
      Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
      Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    3. "Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation."
      Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P., Cornman R.S., Evans J.D., Delbac F., Peyret P.
      BMC Genomics 10:607-607(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GB-M1.
    4. "Putative thymidine kinase of Encephalitozoon cuniculi (Microspora) from the chromosome I."
      Duffieux F., Peyret P., Roe B.A., Vivares C.P.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-232.

    Entry informationi

    Entry nameiKITH_ENCCU
    AccessioniPrimary (citable) accession number: O96720
    Secondary accession number(s): Q8SSL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 29, 2013
    Last modified: October 1, 2014
    This is version 69 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3