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O96720 (KITH_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
Ordered Locus Names:ECU01_0740i
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Thymidine kinase
PRO_0000174951

Regions

Nucleotide binding31 – 388ATP Potential
Nucleotide binding63 – 653ATP By similarity
Nucleotide binding106 – 1094ATP By similarity

Sites

Active site1071Proton acceptor Potential
Metal binding1641Zinc By similarity
Metal binding1671Zinc By similarity
Metal binding2031Zinc By similarity
Metal binding2061Zinc By similarity
Binding site1391Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
O96720 [UniParc].

Last modified May 29, 2013. Version 3.
Checksum: 3017360E71AF9BBA

FASTA23225,958
        10         20         30         40         50         60 
MDLAVLEWKS IKRRNAPTAE MTRGTLNFVT SPMNAGKTAN MLLRARHAAT LGRRVLLAKP 

        70         80         90        100        110        120 
LSDTRHESSV IRSRCGIEMK CDLCAGPEFS FTKDVLYGDV DILLVDEAQF LSSRQIDELR 

       130        140        150        160        170        180 
EVADVHGIPV WCYGLLTDFK KNLFEGSKRL VELCDKMIEL DIVCYFCKAD GRFHLKYANG 

       190        200        210        220        230 
KAVVEGPSID ISIPGDGKFV AVCHMCWTEK TSTSEEVQDP RVLCAKVIPV DR 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[3]"Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation."
Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P., Cornman R.S., Evans J.D., Delbac F., Peyret P.
BMC Genomics 10:607-607(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: GB-M1.
[4]"Putative thymidine kinase of Encephalitozoon cuniculi (Microspora) from the chromosome I."
Duffieux F., Peyret P., Roe B.A., Vivares C.P.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-232.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL391737 Genomic DNA. Translation: CAD24944.2.
AJ006824 Genomic DNA. Translation: CAA07261.1.
RefSeqXP_965909.1. XM_960816.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU01_0740i.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID860249.
KEGGecu:ECU01_0740i.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU01_0740i.

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076391.
KOK00857.
OrthoDBEOG7Z3FGM.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_ENCCU
AccessionPrimary (citable) accession number: O96720
Secondary accession number(s): Q8SSL4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 29, 2013
Last modified: July 9, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families