ID   TYSY_ASCSU              Reviewed;         294 AA.
AC   O96650;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Thymidylate synthase;
DE            Short=TSase;
DE            Short=TS;
DE            EC=2.1.1.45;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea;
OC   Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tian L., Tam J.W.O.;
RT   "Molecular cloning of thymidylate synthase from Ascaris suum.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF099672; AAC97507.1; -; mRNA.
DR   HSSP; P04818; 1HVY.
DR   BRENDA; 2.1.1.45; 649.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:EC.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   InterPro; IPR000398; Thymidylat_synth_C.
DR   Gene3D; G3DSA:3.30.572.10; Thymidylat_synth_C; 1.
DR   PANTHER; PTHR11549:SF2; Thymidylat_synth_C; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   ProDom; PD001180; Thymidylat_synth; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Nucleotide biosynthesis; Transferase.
FT   CHAIN         1    294       Thymidylate synthase.
FT                                /FTId=PRO_0000140904.
FT   ACT_SITE    176    176       By similarity.
SQ   SEQUENCE   294 AA;  33054 MW;  CDFD4556972A3C50 CRC64;
     MEGANVNEDE RKYLRQIKHI IDEGDKVIDR TGVGTLSLFG LHSTYSLRNG VIPLLTTKRV
     YWKGVVEELL WFIKGDTDAK RLSAKGVKIW DANGSREFLD SQGFKDRPEG DLGPIYGFQW
     RHFGAEYHGT DADYKGQGVD QLADVIEQIK NNPNSRRIIL NAWNVKDLHQ MALPPCHTLA
     QFAVKNGELS CQLYQRSGDM GLGVPFNLAS YGLLTHMIAH VCALKTGFLH HVLGDAHVYL
     NHIDALKEQL SRDPRPFPTV HFEGRIDSID DFTAESIILN GYNPMAPIKM PMAV
//