Reviewed, UniProtKB/Swiss-Prot O96650 (TYSY_ASCSU)

Names and origin

Protein names	Recommended name:     Thymidylate synthase       Short name=TSase       Short name=TS     EC=2.1.1.45
Organism	Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifier	6253 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Ascaridida › Ascaridoidea › Ascarididae › Ascaris

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Thymidylate synthase		PRO_0000140904
Sites
	Active site	176	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O96650-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: CDFD4556972A3C50	FASTA	294	33,054
	10 20 30 40 50 60 MEGANVNEDE RKYLRQIKHI IDEGDKVIDR TGVGTLSLFG LHSTYSLRNG VIPLLTTKRV 70 80 90 100 110 120 YWKGVVEELL WFIKGDTDAK RLSAKGVKIW DANGSREFLD SQGFKDRPEG DLGPIYGFQW 130 140 150 160 170 180 RHFGAEYHGT DADYKGQGVD QLADVIEQIK NNPNSRRIIL NAWNVKDLHQ MALPPCHTLA 190 200 210 220 230 240 QFAVKNGELS CQLYQRSGDM GLGVPFNLAS YGLLTHMIAH VCALKTGFLH HVLGDAHVYL 250 260 270 280 290 NHIDALKEQL SRDPRPFPTV HFEGRIDSID DFTAESIILN GYNPMAPIKM PMAV

References

[1]	"Molecular cloning of thymidylate synthase from Ascaris suum." Tian L., Tam J.W.O. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF099672 mRNA. Translation: AAC97507.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.1.1.45. 649.
Family and domain databases
InterPro	IPR000398. Thymidylat_synth_C. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_ASCSU

Accession

Primary (citable) accession number: O96650

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)