O96571 (DDC_DROLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aromatic-L-amino-acid decarboxylase
Short name=AADC
EC=4.1.1.28

Alternative name(s):
DOPA decarboxylase
Short name=DDC

Gene names

Name:

Ddc

Organism

Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)

Taxonomic identifier

7225 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Scaptodrosophila › victoria group

Protein attributes

Sequence length	403 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Catalytic activity	L-dopa = dopamine + CO2. 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.
Cofactor	Pyridoxal phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Biological process	Catecholamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological_process	catecholamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	aromatic-L-amino-acid decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 403	›403	Aromatic-L-amino-acid decarboxylase		PRO_0000146946
Sites
	Binding site	8	1	Substrate By similarity
	Binding site	118	1	Substrate By similarity
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	O96571 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 558EB9B284D5D283	FASTA	403	45,134
	10 20 30 40 50 60 KFHAYFPTAN SYPAIVADML SGAIACIGFT WIASPACTEL EVAMLDWLGK MLELPAEFLA 70 80 90 100 110 120 CSGGKGGGVI QGTASEATLV ALLGAKAKKM KEVRETHPDW DDHTIISKLV GYSSAQAHSS 130 140 150 160 170 180 VERAGLLGGV KLRSVPADEQ NRLRGEALEK AIEQDLADGL IPFYAVVTLG TTNSCAFDRL 190 200 210 220 230 240 DECGPVANKH NVWVHVDAAY AGSAFICPEY RHLMKGIETA DSFNFNPHKW MLVNFDCSAM 250 260 270 280 290 300 WLKDPSWVVN AFNVDPLYLK HDMQGSAPDY RHWQIPIGRR FRALKLWFVL RLYGVENLQA 310 320 330 340 350 360 HIRRHCTYAQ QFAELCVQDS RFELAAEVNM GLVCFRLKGS NERNEALLKR INGRGKIHLV 370 380 390 400 PAKIRDVYFL RMAVCSRFTR PEDMEYSWQE VSAAADEEEQ QQK

References

[1]	"A compact gene cluster in Drosophila: the unrelated Cs gene is compressed between duplicated amd and Ddc." Tatarenkov A., Saez A.G., Ayala F.J. Gene 231:111-120(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Beirut.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091329 Genomic DNA. Translation: AAC67585.1.
3D structure databases
ProteinModelPortal	O96571.
SMR	O96571. Positions 1-397.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0025671. Dleb\Ddc.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR010977. Aromatic_deC. IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR021115. Pyridoxal-P_BS. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
PRINTS	PR00800. YHDCRBOXLASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DDC_DROLE

Accession

Primary (citable) accession number: O96571

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project