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O96559

- APY_CIMLE

UniProt

O96559 - APY_CIMLE

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Protein

Apyrase

Gene
APY
Organism
Cimex lectularius (Bed bug) (Acanthia lectularia)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits platlet aggregation by the calcium-dependent hydrolysis of ATP and ADP.1 Publication

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.1 Publication

Cofactori

Calcium.1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-dependent ATPase activity Source: UniProtKB
  3. calcium ion binding Source: InterPro
  4. nucleoside-diphosphatase activity Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. metabolic process Source: GOC
  3. negative regulation of blood coagulation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apyrase (EC:3.6.1.5)
Gene namesi
Name:APY
OrganismiCimex lectularius (Bed bug) (Acanthia lectularia)
Taxonomic identifieri79782 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraCimicomorphaCimicidaeCimex

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 35351 PublicationAdd
BLAST
Chaini36 – 364329Apyrase1 PublicationPRO_0000234527Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO96559.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 288Poly-Leu

Sequence similaritiesi

Belongs to the apyrase family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR009283. Apyrase.
[Graphical view]
PANTHERiPTHR13023. PTHR13023. 1 hit.
PfamiPF06079. Apyrase. 1 hit.
[Graphical view]
SUPFAMiSSF101887. SSF101887. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96559-1 [UniParc]FASTAAdd to Basket

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MRSSYRVGNP IRFQPTNVVG LLLLSLVLSF MLVQSYELGH ASGETNANSK    50
YPLTTPVEEN LKVRFKIGVI SDDDKNAVSK DESNTWVSTY LTGTLEWEKS 100
TDKITVQWDK GNEKKVKSKY SYGGRGMELS ELVTFNGNLL TFDDRTGLVY 150
ILKDDKVYPW VVLADGDGKN SKGFKSEWAT EKAGNLYVGS SGKEWTTKEG 200
TIENYNPMWV KMINKNGEVT SLNWQTNYEK IRSSMNITFP GYMWHEAACW 250
SDKYNKWFFL PRALSQEAYD SKKFETQGAN VIISCDDKFE KCEPTQIQGK 300
TEDKRGFSNF KFVPTSEDKI IVGLKTVEAD DTTETYFTAF DLEGKVLLEE 350
TKIDDHKYEG VDFV 364
Length:364
Mass (Da):41,474
Last modified:May 1, 1999 - v1
Checksum:iC398CB6D29A882DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085499 mRNA. Translation: AAD09177.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085499 mRNA. Translation: AAD09177.1 .

3D structure databases

ProteinModelPortali O96559.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR009283. Apyrase.
[Graphical view ]
PANTHERi PTHR13023. PTHR13023. 1 hit.
Pfami PF06079. Apyrase. 1 hit.
[Graphical view ]
SUPFAMi SSF101887. SSF101887. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius. A new type of nucleotide-binding enzyme."
    Valenzuela J.G., Charlab R., Galperin M.Y., Ribeiro J.M.C.
    J. Biol. Chem. 273:30583-30590(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 36-85; 263-284 AND 326-345, FUNCTION, CATALYTIC ACTIVITY, COFACTOR.
    Tissue: Salivary gland.

Entry informationi

Entry nameiAPY_CIMLE
AccessioniPrimary (citable) accession number: O96559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3