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O96559

- APY_CIMLE

UniProt

O96559 - APY_CIMLE

Protein

Apyrase

Gene

APY

Organism
Cimex lectularius (Bed bug) (Acanthia lectularia)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Inhibits platlet aggregation by the calcium-dependent hydrolysis of ATP and ADP.1 Publication

    Catalytic activityi

    A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.1 Publication

    Cofactori

    Calcium.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-dependent ATPase activity Source: UniProtKB
    3. calcium ion binding Source: InterPro
    4. nucleoside-diphosphatase activity Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. metabolic process Source: GOC
    3. negative regulation of blood coagulation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Calcium, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apyrase (EC:3.6.1.5)
    Gene namesi
    Name:APYImported
    OrganismiCimex lectularius (Bed bug) (Acanthia lectularia)
    Taxonomic identifieri79782 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraCimicomorphaCimicidaeCimex

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 35351 PublicationAdd
    BLAST
    Chaini36 – 364329Apyrase1 PublicationPRO_0000234527Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO96559.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 288Poly-LeuSequence Analysis

    Sequence similaritiesi

    Belongs to the apyrase family.Sequence Analysis

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR009283. Apyrase.
    [Graphical view]
    PANTHERiPTHR13023. PTHR13023. 1 hit.
    PfamiPF06079. Apyrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF101887. SSF101887. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O96559-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSSYRVGNP IRFQPTNVVG LLLLSLVLSF MLVQSYELGH ASGETNANSK    50
    YPLTTPVEEN LKVRFKIGVI SDDDKNAVSK DESNTWVSTY LTGTLEWEKS 100
    TDKITVQWDK GNEKKVKSKY SYGGRGMELS ELVTFNGNLL TFDDRTGLVY 150
    ILKDDKVYPW VVLADGDGKN SKGFKSEWAT EKAGNLYVGS SGKEWTTKEG 200
    TIENYNPMWV KMINKNGEVT SLNWQTNYEK IRSSMNITFP GYMWHEAACW 250
    SDKYNKWFFL PRALSQEAYD SKKFETQGAN VIISCDDKFE KCEPTQIQGK 300
    TEDKRGFSNF KFVPTSEDKI IVGLKTVEAD DTTETYFTAF DLEGKVLLEE 350
    TKIDDHKYEG VDFV 364
    Length:364
    Mass (Da):41,474
    Last modified:May 1, 1999 - v1
    Checksum:iC398CB6D29A882DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085499 mRNA. Translation: AAD09177.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085499 mRNA. Translation: AAD09177.1 .

    3D structure databases

    ProteinModelPortali O96559.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR009283. Apyrase.
    [Graphical view ]
    PANTHERi PTHR13023. PTHR13023. 1 hit.
    Pfami PF06079. Apyrase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101887. SSF101887. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius. A new type of nucleotide-binding enzyme."
      Valenzuela J.G., Charlab R., Galperin M.Y., Ribeiro J.M.C.
      J. Biol. Chem. 273:30583-30590(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 36-85; 263-284 AND 326-345, FUNCTION, CATALYTIC ACTIVITY, COFACTOR.
      Tissue: Salivary glandImported.

    Entry informationi

    Entry nameiAPY_CIMLE
    AccessioniPrimary (citable) accession number: O96559
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3