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Protein

Apyrase

Gene

APY

Organism
Cimex lectularius (Bed bug) (Acanthia lectularia)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits platlet aggregation by the calcium-dependent hydrolysis of ATP and ADP.1 Publication

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.1 Publication

Cofactori

Ca2+1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of blood coagulation Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apyrase (EC:3.6.1.5)
Gene namesi
Name:APYImported
OrganismiCimex lectularius (Bed bug) (Acanthia lectularia)
Taxonomic identifieri79782 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraHeteropteraPanheteropteraCimicomorphaCimicidaeCimex

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 351 PublicationAdd BLAST35
ChainiPRO_000023452736 – 364Apyrase1 PublicationAdd BLAST329

Structurei

3D structure databases

ProteinModelPortaliO96559
SMRiO96559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 28Poly-LeuSequence analysis8

Sequence similaritiesi

Belongs to the apyrase family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.120.10.100, 1 hit
InterProiView protein in InterPro
IPR009283 Apyrase
IPR036258 Apyrase_sf
PANTHERiPTHR13023 PTHR13023, 1 hit
PfamiView protein in Pfam
PF06079 Apyrase, 1 hit
SUPFAMiSSF101887 SSF101887, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSYRVGNP IRFQPTNVVG LLLLSLVLSF MLVQSYELGH ASGETNANSK
60 70 80 90 100
YPLTTPVEEN LKVRFKIGVI SDDDKNAVSK DESNTWVSTY LTGTLEWEKS
110 120 130 140 150
TDKITVQWDK GNEKKVKSKY SYGGRGMELS ELVTFNGNLL TFDDRTGLVY
160 170 180 190 200
ILKDDKVYPW VVLADGDGKN SKGFKSEWAT EKAGNLYVGS SGKEWTTKEG
210 220 230 240 250
TIENYNPMWV KMINKNGEVT SLNWQTNYEK IRSSMNITFP GYMWHEAACW
260 270 280 290 300
SDKYNKWFFL PRALSQEAYD SKKFETQGAN VIISCDDKFE KCEPTQIQGK
310 320 330 340 350
TEDKRGFSNF KFVPTSEDKI IVGLKTVEAD DTTETYFTAF DLEGKVLLEE
360
TKIDDHKYEG VDFV
Length:364
Mass (Da):41,474
Last modified:May 1, 1999 - v1
Checksum:iC398CB6D29A882DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085499 mRNA Translation: AAD09177.1
RefSeqiNP_001303629.1, NM_001316700.1

Genome annotation databases

GeneIDi106669828

Similar proteinsi

Entry informationi

Entry nameiAPY_CIMLE
AccessioniPrimary (citable) accession number: O96559
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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