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Protein
Submitted name:

Tryparedoxin

Gene

TryX

Organism
Crithidia fasciculata
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
TryparedoxinImported
Submitted name:
Tryparedoxin IImported
Gene namesi
Name:TryXImported
Synonyms:txnIImported
OrganismiCrithidia fasciculataImported
Taxonomic identifieri5656 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 43Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EWXX-ray1.70A2-146[»]
1EZKX-ray1.90A2-146[»]
1O7UX-ray1.50A1-146[»]
1O85X-ray1.50A1-146[»]
1O8WX-ray1.70A1-146[»]
1O8XX-ray1.30A1-42[»]
A44-146[»]
1OKDNMR-A1-146[»]
1QK8X-ray1.40A1-146[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO96438.

Family & Domainsi

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13905. Thioredoxin_8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O96438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLDKYLPG IEKLRRGDGE VEVKSLAGKL VFFYFSASWC PPCRGFTPQL
60 70 80 90 100
IEFYDKFHES KNFEVVFCTW DEEEDGFAGY FAKMPWLAVP FAQSEAVQKL
110 120 130 140
SKHFNVESIP TLIGVDADSG DVVTTRARAT LVKDPEGEQF PWKDAP
Length:146
Mass (Da):16,481
Last modified:May 1, 1999 - v1
Checksum:iC9663DE8FD803D43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055913 Genomic DNA. Translation: AAC72299.1.
AF084456 Genomic DNA. Translation: AAD20445.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055913 Genomic DNA. Translation: AAC72299.1.
AF084456 Genomic DNA. Translation: AAD20445.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EWXX-ray1.70A2-146[»]
1EZKX-ray1.90A2-146[»]
1O7UX-ray1.50A1-146[»]
1O85X-ray1.50A1-146[»]
1O8WX-ray1.70A1-146[»]
1O8XX-ray1.30A1-42[»]
A44-146[»]
1OKDNMR-A1-146[»]
1QK8X-ray1.40A1-146[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO96438.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13905. Thioredoxin_8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence, heterologous expression and functional characterization of a novel tryparedoxin from Crithidia fasciculata."
    Montemartini M., Kalisz H.M., Kiess M., Nogoceke E., Singh M., Steinert P., Flohe L.
    Biol. Chem. 379:1137-1142(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HS6Imported.
  2. "Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata."
    Tetaud E., Fairlamb A.H.
    Mol. Biochem. Parasitol. 96:111-123(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Guerrero S., Flohe L., Kalisz H.M., Montemartini M., Nogoceke E., Hecht H.-J., Steinert P., Singh M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HS6Imported.
  4. "Sequence, heterologous expression and functional characterization of tryparedoxin1 from Crithidia fasciculata."
    Guerrero S.A., Flohe L., Kalisz H.M., Montemartini M., Nogoceke E., Hecht H.J., Steinert P., Singh M.
    Eur. J. Biochem. 259:789-794(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HS6Imported.
  5. "The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I."
    Alphey M.S., Leonard G.A., Gourley D.G., Tetaud E., Fairlamb A.H., Hunter W.N.
    J. Biol. Chem. 274:25613-25622(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS), ACTIVE SITE.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-146, ACTIVE SITE.
  7. "NMR studies of the interaction of tryparedoxin with redox-inactive substrate homologues."
    Krumme D., Budde H., Hecht H.J., Menge U., Ohlenschlager O., Ross A., Wissing J., Wray V., Flohe L.
    Biochemistry 42:14720-14728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, ACTIVE SITE.
  8. "Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function."
    Alphey M.S., Gabrielsen M., Micossi E., Leonard G.A., McSweeney S.M., Ravelli R.B., Tetaud E., Fairlamb A.H., Bond C.S., Hunter W.N.
    J. Biol. Chem. 278:25919-25925(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 1-42 AND 44-146, ACTIVE SITE.

Entry informationi

Entry nameiO96438_CRIFA
AccessioniPrimary (citable) accession number: O96438
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.