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O96438

- O96438_CRIFA

UniProt

O96438 - O96438_CRIFA

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Protein
Submitted name:

Tryparedoxin

Gene
TryX, txnI
Organism
Crithidia fasciculata
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
TryparedoxinImported
Submitted name:
Tryparedoxin IImported
Gene namesi
Name:TryXImported
Synonyms:txnIImported
OrganismiCrithidia fasciculataImported
Taxonomic identifieri5656 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-actyl XImported

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EWXX-ray1.70A2-146[»]
1EZKX-ray1.90A2-146[»]
1O7UX-ray1.50A1-146[»]
1O85X-ray1.50A1-146[»]
1O8WX-ray1.70A1-146[»]
1O8XX-ray1.30A1-42[»]
A44-146[»]
1OKDNMR-A1-146[»]
1QK8X-ray1.40A1-146[»]

Miscellaneous databases

EvolutionaryTraceiO96438.

Family & Domainsi

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13905. Thioredoxin_8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O96438-1 [UniParc]FASTAAdd to Basket

« Hide

MSGLDKYLPG IEKLRRGDGE VEVKSLAGKL VFFYFSASWC PPCRGFTPQL    50
IEFYDKFHES KNFEVVFCTW DEEEDGFAGY FAKMPWLAVP FAQSEAVQKL 100
SKHFNVESIP TLIGVDADSG DVVTTRARAT LVKDPEGEQF PWKDAP 146
Length:146
Mass (Da):16,481
Last modified:May 1, 1999 - v1
Checksum:iC9663DE8FD803D43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055913 Genomic DNA. Translation: AAC72299.1.
AF084456 Genomic DNA. Translation: AAD20445.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055913 Genomic DNA. Translation: AAC72299.1 .
AF084456 Genomic DNA. Translation: AAD20445.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EWX X-ray 1.70 A 2-146 [» ]
1EZK X-ray 1.90 A 2-146 [» ]
1O7U X-ray 1.50 A 1-146 [» ]
1O85 X-ray 1.50 A 1-146 [» ]
1O8W X-ray 1.70 A 1-146 [» ]
1O8X X-ray 1.30 A 1-42 [» ]
A 44-146 [» ]
1OKD NMR - A 1-146 [» ]
1QK8 X-ray 1.40 A 1-146 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei O96438.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13905. Thioredoxin_8. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence, heterologous expression and functional characterization of a novel tryparedoxin from Crithidia fasciculata."
    Montemartini M., Kalisz H.M., Kiess M., Nogoceke E., Singh M., Steinert P., Flohe L.
    Biol. Chem. 379:1137-1142(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HS6Imported.
  2. "Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata."
    Tetaud E., Fairlamb A.H.
    Mol. Biochem. Parasitol. 96:111-123(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Guerrero S., Flohe L., Kalisz H.M., Montemartini M., Nogoceke E., Hecht H.-J., Steinert P., Singh M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HS6Imported.
  4. "Sequence, heterologous expression and functional characterization of tryparedoxin1 from Crithidia fasciculata."
    Guerrero S.A., Flohe L., Kalisz H.M., Montemartini M., Nogoceke E., Hecht H.J., Steinert P., Singh M.
    Eur. J. Biochem. 259:789-794(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HS6Imported.
  5. "The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I."
    Alphey M.S., Leonard G.A., Gourley D.G., Tetaud E., Fairlamb A.H., Hunter W.N.
    J. Biol. Chem. 274:25613-25622(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS).
  6. Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-146, N-ACTYL X AT SER-2.
  7. "NMR studies of the interaction of tryparedoxin with redox-inactive substrate homologues."
    Krumme D., Budde H., Hecht H.J., Menge U., Ohlenschlager O., Ross A., Wissing J., Wray V., Flohe L.
    Biochemistry 42:14720-14728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  8. "Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function."
    Alphey M.S., Gabrielsen M., Micossi E., Leonard G.A., McSweeney S.M., Ravelli R.B., Tetaud E., Fairlamb A.H., Bond C.S., Hunter W.N.
    J. Biol. Chem. 278:25919-25925(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 1-42 AND 44-146.

Entry informationi

Entry nameiO96438_CRIFA
AccessioniPrimary (citable) accession number: O96438
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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