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O96438

- O96438_CRIFA

UniProt

O96438 - O96438_CRIFA

Protein
Submitted name:

Tryparedoxin

Gene

TryX

Organism
Crithidia fasciculata
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Submitted name:
    TryparedoxinImported
    Submitted name:
    Tryparedoxin IImported
    Gene namesi
    Name:TryXImported
    Synonyms:txnIImported
    OrganismiCrithidia fasciculataImported
    Taxonomic identifieri5656 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-actyl XImported

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EWXX-ray1.70A2-146[»]
    1EZKX-ray1.90A2-146[»]
    1O7UX-ray1.50A1-146[»]
    1O85X-ray1.50A1-146[»]
    1O8WX-ray1.70A1-146[»]
    1O8XX-ray1.30A1-42[»]
    A44-146[»]
    1OKDNMR-A1-146[»]
    1QK8X-ray1.40A1-146[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO96438.

    Family & Domainsi

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13905. Thioredoxin_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O96438-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGLDKYLPG IEKLRRGDGE VEVKSLAGKL VFFYFSASWC PPCRGFTPQL    50
    IEFYDKFHES KNFEVVFCTW DEEEDGFAGY FAKMPWLAVP FAQSEAVQKL 100
    SKHFNVESIP TLIGVDADSG DVVTTRARAT LVKDPEGEQF PWKDAP 146
    Length:146
    Mass (Da):16,481
    Last modified:May 1, 1999 - v1
    Checksum:iC9663DE8FD803D43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055913 Genomic DNA. Translation: AAC72299.1.
    AF084456 Genomic DNA. Translation: AAD20445.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055913 Genomic DNA. Translation: AAC72299.1 .
    AF084456 Genomic DNA. Translation: AAD20445.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EWX X-ray 1.70 A 2-146 [» ]
    1EZK X-ray 1.90 A 2-146 [» ]
    1O7U X-ray 1.50 A 1-146 [» ]
    1O85 X-ray 1.50 A 1-146 [» ]
    1O8W X-ray 1.70 A 1-146 [» ]
    1O8X X-ray 1.30 A 1-42 [» ]
    A 44-146 [» ]
    1OKD NMR - A 1-146 [» ]
    1QK8 X-ray 1.40 A 1-146 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei O96438.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13905. Thioredoxin_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, heterologous expression and functional characterization of a novel tryparedoxin from Crithidia fasciculata."
      Montemartini M., Kalisz H.M., Kiess M., Nogoceke E., Singh M., Steinert P., Flohe L.
      Biol. Chem. 379:1137-1142(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HS6Imported.
    2. "Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata."
      Tetaud E., Fairlamb A.H.
      Mol. Biochem. Parasitol. 96:111-123(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Guerrero S., Flohe L., Kalisz H.M., Montemartini M., Nogoceke E., Hecht H.-J., Steinert P., Singh M.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HS6Imported.
    4. "Sequence, heterologous expression and functional characterization of tryparedoxin1 from Crithidia fasciculata."
      Guerrero S.A., Flohe L., Kalisz H.M., Montemartini M., Nogoceke E., Hecht H.J., Steinert P., Singh M.
      Eur. J. Biochem. 259:789-794(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HS6Imported.
    5. "The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I."
      Alphey M.S., Leonard G.A., Gourley D.G., Tetaud E., Fairlamb A.H., Hunter W.N.
      J. Biol. Chem. 274:25613-25622(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS).
    6. Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-146.
    7. "NMR studies of the interaction of tryparedoxin with redox-inactive substrate homologues."
      Krumme D., Budde H., Hecht H.J., Menge U., Ohlenschlager O., Ross A., Wissing J., Wray V., Flohe L.
      Biochemistry 42:14720-14728(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    8. "Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function."
      Alphey M.S., Gabrielsen M., Micossi E., Leonard G.A., McSweeney S.M., Ravelli R.B., Tetaud E., Fairlamb A.H., Bond C.S., Hunter W.N.
      J. Biol. Chem. 278:25919-25925(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 1-42 AND 44-146.

    Entry informationi

    Entry nameiO96438_CRIFA
    AccessioniPrimary (citable) accession number: O96438
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3