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Protein

Carbamate kinase

Gene

CBK

Organism
Trichomonas vaginalis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + NH3 + CO2 = ADP + carbamoyl phosphate.

Pathwayi: carbamoyl phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Carbamate kinase (CBK)
This subpathway is part of the pathway carbamoyl phosphate degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate, the pathway carbamoyl phosphate degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.2.2. 6459.
UniPathwayiUPA00996; UER00366.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamate kinase (EC:2.7.2.2)
Gene namesi
Name:CBK
OrganismiTrichomonas vaginalis
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Carbamate kinasePRO_0000185153Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi5722.O96432.

Structurei

3D structure databases

ProteinModelPortaliO96432.
SMRiO96432. Positions 2-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbamate kinase family.Curated

Phylogenomic databases

eggNOGiENOG410IZE4. Eukaryota.
COG0549. LUCA.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.

Sequencei

Sequence statusi: Complete.

O96432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVVALGGN ALLQRGMKGT FQDQQAACRL AMSQIVKIVK DGNELVMTHG
60 70 80 90 100
NGPQCGAIFL QNVAGEQEKV PAMPLHVCGA ETQGFLGELL QQELDGALRA
110 120 130 140 150
EGIKKNVVSI VTQSFVDPKD PAFQNPTKPI GPFYSKEEAE FLRNERGYNM
160 170 180 190 200
VEDAGRGYRM IVPSPVPQKF VEKEAIKTLV NSGFIVVCSG GGGIPVILDE
210 220 230 240 250
QENRIEGVDA VIDKDLGASV LAAATNADAF MILTDVPEAL LNYRKENETA
260 270 280 290 300
IRQATVAEME KYIEEGHFIK GSMLPKVQAC LRFVKSTGKP ALITALDCAL
310
QALKGERGTK IVPN
Length:314
Mass (Da):33,927
Last modified:May 1, 1999 - v1
Checksum:i4E00507941CF340C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050082 Genomic DNA. Translation: AAD02507.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050082 Genomic DNA. Translation: AAD02507.1.

3D structure databases

ProteinModelPortaliO96432.
SMRiO96432. Positions 2-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5722.O96432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IZE4. Eukaryota.
COG0549. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00996; UER00366.
BRENDAi2.7.2.2. 6459.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Trichomonas vaginalis: characterization, expression, and phylogenetic analysis of a carbamate kinase gene sequence."
    Minotto L., Edwards M.R., Bagnara A.S.
    Exp. Parasitol. 95:54-62(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY, CHARACTERIZATION.
    Strain: WAA38.

Entry informationi

Entry nameiCBK_TRIVA
AccessioniPrimary (citable) accession number: O96432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.