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Protein
Submitted name:

RE17884p

Gene

TfAP-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • adult feeding behavior Source: FlyBase
  • adult locomotory behavior Source: FlyBase
  • imaginal disc-derived leg joint morphogenesis Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • imaginal disc-derived male genitalia development Source: FlyBase
  • inter-male aggressive behavior Source: FlyBase
  • male courtship behavior Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • proboscis development Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-8864260. Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.
R-DME-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-DME-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
R-DME-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.

Names & Taxonomyi

Protein namesi
Submitted name:
RE17884pImported
Submitted name:
Transcription factor AP-2Imported
Submitted name:
Transcription factor AP-2, isoform BImported
Gene namesi
Name:TfAP-2Imported
Synonyms:AP-2Imported
ORF Names:CG7807Imported, Dmel_CG7807Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261953. TfAP-2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0261953.

Interactioni

Protein-protein interaction databases

MINTiMINT-335312.
STRINGi7227.FBpp0305656.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 434TF_AP-2InterPro annotationAdd BLAST194

Phylogenomic databases

eggNOGiKOG3811. Eukaryota.
ENOG410XR9E. LUCA.
GeneTreeiENSGT00550000074577.
OrthoDBiEOG091G0PR6.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01748. AP2TNSCPFCT.

Sequencei

Sequence statusi: Complete.

O96378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHILHRTNDH QFEDQKFMME RLSGHGSLGL SSGSAAYTTH SGGHTGRSGP
60 70 80 90 100
ATGHSGHSST HGSAATMHHQ SLQSDFQPPY FPPPFHHSTQ SPPQQQNHGA
110 120 130 140 150
LEYLGTDPYG QPLSSLHHAP LHHYNQLAGL RSTQDQLGIH RTHREAELQG
160 170 180 190 200
HVTQLSHGFP YTDRRSDYGS AISAGAAHGT RLGHEHESLA LHQALQNAVD
210 220 230 240 250
DVQAPALDDN VAFMSDLPLI KSMKSGKEAG NIGSGSPSEV FCAVPGRLSL
260 270 280 290 300
LSSTSKYKVT IAEVQRRLSP PECLNASLLG GVLRRAKSKN GGRLLREKLE
310 320 330 340 350
KIGLNLPAGR RKAANVTLLT SLVEGEATHL AKDFHFVCET EFPARQLAEY
360 370 380 390 400
IVRHQTEPQD SYRRKELILH SQQITKELMQ ILSQDRTTHF GTRSQHLLEP
410 420 430 440 450
SMQRHLTHFS LITHGFGSPA IMAVLHAFQT FLNESLNYLE KLYPSNGGGM
460
VSSSLDKSKI DNEKK
Length:465
Mass (Da):51,123
Last modified:May 1, 1999 - v1
Checksum:i39B3097EEDBC2502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033030 mRNA. Translation: AAC64676.1.
AY071140 mRNA. Translation: AAL48762.1.
AE014296 Genomic DNA. Translation: AAN12183.1.
RefSeqiNP_649336.1. NM_141079.3.
UniGeneiDm.3243.

Genome annotation databases

EnsemblMetazoaiFBtr0078418; FBpp0078072; FBgn0261953.
GeneIDi40398.
UCSCiCG7807-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033030 mRNA. Translation: AAC64676.1.
AY071140 mRNA. Translation: AAL48762.1.
AE014296 Genomic DNA. Translation: AAN12183.1.
RefSeqiNP_649336.1. NM_141079.3.
UniGeneiDm.3243.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-335312.
STRINGi7227.FBpp0305656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078418; FBpp0078072; FBgn0261953.
GeneIDi40398.
UCSCiCG7807-RB. d. melanogaster.

Organism-specific databases

CTDi40398.
FlyBaseiFBgn0261953. TfAP-2.

Phylogenomic databases

eggNOGiKOG3811. Eukaryota.
ENOG410XR9E. LUCA.
GeneTreeiENSGT00550000074577.
OrthoDBiEOG091G0PR6.

Enzyme and pathway databases

ReactomeiR-DME-8864260. Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.
R-DME-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-DME-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
R-DME-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.

Miscellaneous databases

GenomeRNAii40398.

Gene expression databases

BgeeiFBgn0261953.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01748. AP2TNSCPFCT.
ProtoNetiSearch...

Entry informationi

Entry nameiO96378_DROME
AccessioniPrimary (citable) accession number: O96378
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.