O96363 (BGBP_HYPCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-1,3-glucan-binding protein
Short name=BGBP

Alternative name(s):
Beta-1,3-glucan recognition protein
Short name=BetaGRP
Gram negative bacteria-binding protein

Gene names

Name:

gnbp1

Organism

Hyphantria cunea (Fall webworm moth)

Taxonomic identifier

39466 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Noctuoidea › Arctiidae › Hyphantria

Protein attributes

Sequence length	481 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the recognition of invading micro-organisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade By similarity. UniProtKB Q76DI2
Subcellular location	Secreted By similarity UniProtKB Q76DI2.
Induction	By bacterial infection. Ref.1
Sequence similarities	Belongs to the insect beta-1,3-glucan binding protein family.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro innate immune response Inferred from electronic annotation. Source: UniProtKB-KW regulation of innate immune response Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	extracellular region Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	bacterial cell surface binding Inferred from sequence or structural similarity. Source: UniProtKB hydrolase activity, hydrolyzing O-glycosyl compounds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	‹1 – 18	›18	Potential
	Chain	19 – 481	463	Beta-1,3-glucan-binding protein		PRO_0000002820
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	O96363 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 49B2AC8C406929F6	FASTA	481	53,014
	10 20 30 40 50 60 RCARVCAVLF LFIQISYGQY QVPQVTVQAL KPRGFKASIP DSPSVSLFVF QGNINRAISK 70 80 90 100 110 120 SDIGTISGEI LKAKDGRWTF EDPNVELKVG DVVNYYVVVV SNRGGYIKDN LSFTVSALED 130 140 150 160 170 180 PSSTGTGTDP VPTPTTCRPT ATKLRSGVAC AGQTIFEENF NTFREDVWQI EQYIPVYSTE 190 200 210 220 230 240 FPFVSYQHLS QDPTVAVTGG NLRITPKLQQ RMPGFTDSSI YSGSLNIFSG CTAPAEACMK 250 260 270 280 290 300 DAWGASILPP VVSGRITSKA FAFTYGTVFV KAKLPQGDWI YPEILLEPFL KKYGSTHYSS 310 320 330 340 350 360 GVIKIASARG NRELTSGYTD YSNKMLFGGP VMNLQCYDTL LESKASSNGR QWGDDFHEYV 370 380 390 400 410 420 LRWAPERITL SVDGVEWARV EPTASGLSGR FPQTCSKLPR TFLAAGTKMA PFDDHFYLTL 430 440 450 460 470 480 GVAAGSITEF PDGVQTSGSR PKPWTNTGSK AMLHFWEDMD SWFATWNQPQ LLVDYVKVVA L

References

[1]

"Isolation and characterization of immune-related genes from the fall webworm, Hyphantria cunea, using PCR-based differential display and subtractive cloning." Shin S.W., Park S.-S., Park D.-S., Kim M.G., Kim S.C., Brey P.T., Park H.-Y. Insect Biochem. Mol. Biol. 28:827-837(1998) [PubMed: 9818384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION. Tissue: Larva.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF023916 mRNA. Translation: AAD09290.1.
3D structure databases
ProteinModelPortal	O96363.
ModBase	Search...
Protein family/group databases
CAZy	CBM39. Carbohydrate-Binding Module Family 39. GH16. Glycoside Hydrolase Family 16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008985. ConA-like_lec_gl. IPR013320. ConA-like_subgrp. IPR000757. Glyco_hydro_16. [Graphical view]
Gene3D	G3DSA:2.60.120.200. ConA_like_subgrp. 2 hits.
Pfam	PF00722. Glyco_hydro_16. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BGBP_HYPCU

Accession

Primary (citable) accession number: O96363

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	May 1, 1999
Last modified:	January 11, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)