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Protein
Submitted name:

DNA repair endonuclease, putative

Gene

PF3D7_0206000

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • class I DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-EC
  • class III/IV DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-EC
  • damaged DNA binding Source: GeneDB
  • endonuclease activity Source: GeneDB

GO - Biological processi

  • DNA repair Source: GeneDB

Keywordsi

Molecular functionEndonucleaseImported, Hydrolase, LyaseImported, Nuclease

Names & Taxonomyi

Protein namesi
Submitted name:
DNA repair endonuclease, putativeImported
Submitted name:
DNA repair protein RAD2, putativeImported (EC:4.2.99.18Imported)
Gene namesi
ORF Names:PF3D7_0206000Imported, PFB0265cImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0206000.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 126XPGNInterPro annotationAdd BLAST126
Domaini1220 – 1289XPGIInterPro annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili393 – 413Sequence analysisAdd BLAST21
Coiled coili1183 – 1210Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000284253.
InParanoidiO96154.
KOiK10846.
OMAiFLRICKL.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiView protein in InterPro
IPR036279. 5-3_exonuclease_C_sf.
IPR008918. HhH2.
IPR029060. PIN-like_dom_sf.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
PANTHERiPTHR11081. PTHR11081. 6 hits.
PfamiView protein in Pfam
PF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
PRINTSiPR00853. XPGRADSUPER.
SMARTiView protein in SMART
SM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
SUPFAMiSSF47807. SSF47807. 2 hits.
SSF88723. SSF88723. 3 hits.
PROSITEiView protein in PROSITE
PS00841. XPG_1. 1 hit.

Sequencei

Sequence statusi: Complete.

O96154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVKGLWSIV SPVGVRVNPE IFTGKRIAID VSIWLYELTY ANNVKDLRNK
60 70 80 90 100
SFDNMSIFND LWIDFSENIS SEIKTDNIKK AHLYFFFLRI CKLLYYNIRP
110 120 130 140 150
IFIFDGNPPE LKRKTIFQRN IKKRNYEEKF KKTAEKLVYN YYQRTLLNSM
160 170 180 190 200
KSKNKKNDNS NNIEDKTNTP NKTNTQNKSN TQNKSNTPNK INADISKSSL
210 220 230 240 250
IQIYDDIKEK DKSLNSLVEH VGNVPVSVKD VLTICNDDLS KIKNKIFMIT
260 270 280 290 300
DFGPVLFLGE QDGDMGTVEN INKLDNRNKD ENNLSYSINY NKVQDVNNNN
310 320 330 340 350
DDDKDKDKEN INEVRRDQKN YVYKNKENIN NIYLDDDDEK EDIQNKNGVY
360 370 380 390 400
NNDDIDEQII RKKHMARKKY YESIPKTFKG FLCMRRPVDI IDISNYNTEM
410 420 430 440 450
LEISETLKVH ENKFKQHLNV LDENNSTPVV NMNLLKNINY KKNDDLIEGG
460 470 480 490 500
EKKSFINLIN VDSCYSSSNS RLENDENIER GKINMFITND EKSININNYN
510 520 530 540 550
NNNNNNNNNN NDNNMDNNDV IIEHNKNNMN IYDNKYNVEC SSEKINDNGI
560 570 580 590 600
SNKNINILEL PNNLDTSNIF LEGKDEYKVY YVNKEEIRIP LFKEINKEIF
610 620 630 640 650
EKLPLKLQYQ ILQDIKEEWY TDNRIKAIKS KDDMDVFSQV QLETYVRMIK
660 670 680 690 700
TDFEIEKLKI KMAENIQSVE GELLINKDLS KNTDNINIKD YNVLQKKKSK
710 720 730 740 750
KKKKKFLNDI LNTYNFTTES KYQDLYVKGE ESKEDIKNQI DFVTQECYRN
760 770 780 790 800
NDIIRDTHDK SDIFKNIKID NNKKYEIYNL ELEQEEINEK KNYNKNNNDS
810 820 830 840 850
NKTFFLKIEN EFKKDLLLDD SQIFGDSLLA DIKEYNYTAD NLDNNNENKS
860 870 880 890 900
LYEDGENFIT RNEPITNEYE EKNNIIYISD EQKYNEEDII FKDKIKEKEK
910 920 930 940 950
NNDTSSDDFE NCSVQEKIYV NEKIEEYNNK NDDKSSSSSS IILEEIKYKK
960 970 980 990 1000
EKKDELVSPN LCVLLDEFEH SNDLENNYIS VSSDDMKTNV SKNNITGVKE
1010 1020 1030 1040 1050
NKVDKTNVEY DKKGDDGVIE ISFEDSHKLE ESKFDDNNNI YDNDDELEKN
1060 1070 1080 1090 1100
LSKDYISDVD KNHVNNIYNI ERGEDERENE FVENKIQSTE SHKSNEFICT
1110 1120 1130 1140 1150
ENKSLRKQYM SKEDISNVRI LKSDDINNLS KQNYFEILLD KKQVMDNFQM
1160 1170 1180 1190 1200
NIEQNNDKLK EDKLDEGAYF EYLEDNKIID SYIKETNKEN EELIKEYKKL
1210 1220 1230 1240 1250
KKNNIEINDE MNDDIKLLLN FFGIPYIQSP CEAEAQCSYL NNKNYCDAII
1260 1270 1280 1290 1300
SDDSDVLVFS GKTVIKNFFN KKKTVEVYEK KAIEEKLGLY QEELINISLL
1310 1320 1330 1340 1350
CGCDYTIGVH GIGIVNALEI IKAFPNFEDL KILKDIVSNP FRKIDKNMYN
1360 1370 1380 1390 1400
EEIQQFLNTH KNYKLNWIFP NNFPDREVYK CFKYPKVCTD IKKFEWHVPD
1410 1420 1430 1440 1450
IKSITKFLHK TTNISEEKVL NVLNPILQKY NVNVRTYQSK IEDFFPLLEK
1460 1470 1480 1490 1500
KRKTVDDLID HIRANNKQKR QKNKTVHLDS KISPLIDINP AGIIKSKRMS
1510
SALDHIKRRK SSKKKK
Length:1,516
Mass (Da):178,731
Last modified:May 1, 1999 - v1
Checksum:i7AD7B4AEB58DAD87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001362 Genomic DNA. Translation: AAC71842.1.
LN999943 Genomic DNA. Translation: CZT98073.1.
PIRiE71619.
RefSeqiXP_001349570.1. XM_001349534.1.

Genome annotation databases

EnsemblProtistsiCZT98073; CZT98073; PF3D7_0206000.
GeneDBiPF3D7_0206000.1:pep.
GeneIDi812652.
KEGGipfa:PFB0265c.

Similar proteinsi

Entry informationi

Entry nameiO96154_PLAF7
AccessioniPrimary (citable) accession number: O96154
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: December 20, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported