29-kDa galactose-binding lectin - Lumbricus terrestris (Common earthworm)

Preferred order of sections

Names and origin

Protein names	Submitted name: 29-kDa galactose-binding lectin EMBL BAA36393.1
Organism	Lumbricus terrestris (Common earthworm) EMBL BAA36393.1
Taxonomic identifier	6398 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Annelida › Clitellata › Oligochaeta › Haplotaxida › Lumbricina › Lumbricidae › Lumbricinae › Lumbricus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Lectin EMBL BAA36393.1
Technical term	3D-structure PDB 2ZQO PDB 2DRZ PDB 2DS0 PDB 2ZQN PDB 2DRY
Gene Ontology (GO)
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Region

146 – 150

5

Galactose binding PDB 2DRZ PDB 2DS0 PDB 2ZQN

Region

146 – 150

5

N-acetyl-D-galactosamine binding PDB 2ZQO

Region

161 – 164

4

Galactose binding PDB 2DRZ PDB 2DS0 PDB 2ZQN

Region

230 – 233

4

Galactose binding PDB 2ZQN

Region

230 – 233

4

N-acetyl-D-galactosamine binding PDB 2ZQO

Region

245 – 248

4

N-acetyl-D-galactosamine binding PDB 2ZQO

Sites

Binding site

164

1

N-acetyl-D-galactosamine PDB 2ZQO

Binding site

171

1

Galactose PDB 2DRZ PDB 2DS0 PDB 2ZQN

Binding site

171

1

N-acetyl-D-galactosamine PDB 2ZQO

Binding site

248

1

Galactose PDB 2ZQN

Binding site

252

1

Galactose PDB 2ZQN

Binding site

252

1

N-acetyl-D-galactosamine PDB 2ZQO

Sequences

Sequence

Length

Mass (Da)

Tools

O96048 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 43E62178F0FABF8C
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FASTA

260

29,008

        10         20         30         40         50         60 
MAGRPFLLVS KHSGHALSDP GSHGAPVIVN TRNENDPRQL WYEDASTGTI RNQANQLALH 

        70         80         90        100        110        120 
VGGDNILYLT PAEHGQDAQQ WKVGKDVVHH RNDKEKVFDL CRGSKDVGAQ VCAWKYHGGT 

       130        140        150        160        170        180 
NQQWEAVHLK PKFFYIKSEL NGKVLDIEGQ NPAPGSKIIT WDQKKGPTAV NQLWYTDQQG 

       190        200        210        220        230        240 
VIRSKLNDFA IDASHEQIET QPFDPNNPKR AWIVSGNTIA QLSDRDIVLD IIKSDKEAGA 

       250        260 
HICAWKQHGG PNQKFIIESE

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References

[1]	"Novel galactose-binding proteins in annelid: characterization of 29-kDa tandem-repeat-type lectins from the earthworm Lumbricus terrestris." Hirabayashi J., Dutta S.K., Kasai K. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sugar-complex structures of the C-half domain of the galactose-binding lectin EW29 from the earthworm Lumbricus terrestris." Suzuki R., Kuno A., Hasegawa T., Hirabayashi J., Kasai K.I., Momma M., Fujimoto Z. Acta Crystallogr. D Biol. Crystallogr. 65:49-57(2009) [PubMed: 19153466] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 131-260 IN COMPLEX WITH GALACTOSE AND N-ACETYL-D-GALACTOSAMINE.
[3]	"Tailoring a novel sialic acid-binding lectin from a ricin-B chain-like galactose-binding protein by natural evolution-mimicry." Yabe R., Suzuki R., Kuno A., Fujimoto Z., Jigami Y., Hirabayashi J. J. Biochem. 141:389-399(2007) [PubMed: 17234683] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 131-260 IN COMPLEX WITH GALACTOSE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB010783 mRNA. Translation: BAA36393.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DRY	X-ray	1.80	A/B	131-260	[»]
2DRZ	X-ray	2.19	A/B	131-260	[»]
2DS0	X-ray	1.80	A/B	131-260	[»]
2ZQN	X-ray	1.90	A/B	130-260	[»]
2ZQO	X-ray	1.80	A/B	131-260	[»]

ProteinModelPortal

O96048.

SMR

O96048. Positions 131-260.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR008997. Ricin_B-rel_lectin.
IPR000772. Ricin_B_lectin.
[Graphical view]

Pfam

PF00652. Ricin_B_lectin. 2 hits.
[Graphical view]

SMART

SM00458. RICIN. 2 hits.
[Graphical view]

SUPFAM

SSF50370. RicinB_like. 2 hits.

PROSITE

PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O96048_LUMTE

Accession

Primary (citable) accession number: O96048

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	September 21, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)