O96046 (O96046_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cortactin EMBL BAA34397.1

Gene names

Name:	Cortactin FlyBase FBgn0025865
Synonyms:	DCortactin EMBL BAA34397.1
ORF Names:	CG3637 FlyBase FBgn0025865

Organism

Drosophila melanogaster (Fruit fly) EMBL BAA34397.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH3 domain. RuleBase RU003338

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338
Gene Ontology (GO)
Biological process	border follicle cell migration Inferred from mutant phenotype. Source: FlyBase female germline ring canal formation Inferred from mutant phenotype. Source: FlyBase positive regulation of receptor-mediated endocytosis Inferred from genetic interaction. Source: FlyBase regulation of cell shape Inferred from mutant phenotype. Source: FlyBase
Cellular component	protein complex Inferred from physical interaction. Source: FlyBase sperm individualization complex Inferred from direct assay. Source: FlyBase
Molecular function	proline-rich region binding Inferred from genetic interaction. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O96046 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: DD78CE63948F09CA	FASTA	559	61,075
	10 20 30 40 50 60 MWKASAGHQI QATSAASAED DDWETDPDFV NDVSEQEQRW GSKTIDGSGR TAGTIDMDKL 70 80 90 100 110 120 REETEQADLD KKKQLLKDQN AGYGYGGKFG VEKDRMDKSA VGHDYQGKVG KHASQKDYSD 130 140 150 160 170 180 GFGGKFGVQE DRKDKSAVGW DHVEKVEKHA SQKDYATGFG GKFGVQSDRV DKSAVGWDHI 190 200 210 220 230 240 EKVEKHESQK DYSKGFGGKF GVQEDRKDKS AVGWDHKEAP QKHASQVDHK VKPVIEGAKP 250 260 270 280 290 300 SNLRAKFENL AKNSEEESRK RAEEQKRLRE AKDKRDREEA AKKTVAENTP RTSTEAPPPK 310 320 330 340 350 360 GSRAAIQTGR TGGIGNAISA FNQMQSPVSE TPPARKEPII IPKAQPVKIE VEAKEEPTAS 370 380 390 400 410 420 TTSAAVAPTP TVVPAREPET APVAKATAPP PDVVPQIEVE TVDTPPRSEP QSPVYVPTPQ 430 440 450 460 470 480 PEVLAQVQVQ PEPQPQADPE PVVEEEPLYQ NQAEIKAASP LPPTNGTVSE AVAPSGTATV 490 500 510 520 530 540 PEEAIYANSD NLADYLEDTG IHAIALYDYQ AADDDEISFD PDDVITHIEK IDDGWWRGLC 550 KNRYGLFPAN YVQVVGQNS

References

[1]	"Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse." Katsube T., Takahisa M., Ueda R., Hashimoto N., Kobayashi M., Togashi S. J. Biol. Chem. 273:29672-29677(1998) [PubMed: 9792678] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton-S EMBL BAA34397.1.
[2]	Katsube T., Togashi S. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton-S EMBL BAB01490.1.
[3]	"Characterization of the gene encoding Drosophila Cortactin." Takanori K., Hashimoto N., Sasaki Y., Yamashita A., Takahisa M., Ueda R., Togashi S. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton-S EMBL BAB01490.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009998 mRNA. Translation: BAA34397.1. AB030177 Genomic DNA. Translation: BAB01490.1.
3D structure databases
HSSP	HSSP built from PDB template 1JO8 based on UniProtKB P15891.
ProteinModelPortal	O96046.
SMR	O96046. Positions 498-554.
ModBase	Search...
Protein-protein interaction databases
STRING	O96046.
Proteomic databases
PRIDE	O96046.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0025865. Cortactin.
Phylogenomic databases
eggNOG	inNOG04326.
InParanoid	O96046.
OrthoDB	EOG4J9KF3.
Gene expression databases
ArrayExpress	O96046.
Bgee	O96046.
Family and domain databases
InterPro	IPR015503. Cortactin. IPR003134. Hs1_Cortactin. IPR000108. p67phox. IPR001452. SH3_domain. [Graphical view]
PANTHER	PTHR10829:SF4. Cortactin. 1 hit.
Pfam	PF02218. HS1_rep. 4 hits. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS51090. CORTACTIN. 4 hits. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O96046_DROME

Accession

Primary (citable) accession number: O96046

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	November 16, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)