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Protein

Beta-1,3-galactosyltransferase 4

Gene

B3GALT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in GM1/GD1B/GA1 ganglioside biosynthesis.1 Publication

Catalytic activityi

UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • protein glycosylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.62. 2681.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Chemistry

SwissLipidsiSLP:000000772.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 4 (EC:2.4.1.62)
Short name:
Beta-1,3-GalTase 4
Short name:
Beta3Gal-T4
Short name:
Beta3GalT4
Short name:
GalT4
Short name:
b3Gal-T4
Alternative name(s):
Gal-T2
Ganglioside galactosyltransferase
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
Gene namesi
Name:B3GALT4
Synonyms:GALT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:919. B3GALT4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 1911Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini20 – 378359LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25212.

Polymorphism and mutation databases

BioMutaiB3GALT4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Beta-1,3-galactosyltransferase 4PRO_0000219160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO96024.
PRIDEiO96024.

PTM databases

iPTMnetiO96024.
PhosphoSiteiO96024.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain, placenta, kidney, liver and lung.2 Publications

Gene expression databases

BgeeiO96024.
CleanExiHS_B3GALT4.
ExpressionAtlasiO96024. baseline and differential.
GenevisibleiO96024. HS.

Organism-specific databases

HPAiHPA043001.

Interactioni

Protein-protein interaction databases

BioGridi114248. 3 interactions.
IntActiO96024. 4 interactions.
MINTiMINT-1387639.
STRINGi9606.ENSP00000390784.

Structurei

3D structure databases

ProteinModelPortaliO96024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
HOGENOMiHOG000064523.
HOVERGENiHBG050651.
InParanoidiO96024.
KOiK00715.
OMAiPFCSWLQ.
OrthoDBiEOG76MK8S.
PhylomeDBiO96024.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O96024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLRLFRRLL LAALLLVIVW TLFGPSGLGE ELLSLSLASL LPAPASPGPP
60 70 80 90 100
LALPRLLIPN QEACSGPGAP PFLLILVCTA PENLNQRNAI RASWGGLREA
110 120 130 140 150
RGLRVQTLFL LGEPNAQHPV WGSQGSDLAS ESAAQGDILQ AAFQDSYRNL
160 170 180 190 200
TLKTLSGLNW AEKHCPMARY VLKTDDDVYV NVPELVSELV LRGGRWGQWE
210 220 230 240 250
RSTEPQREAE QEGGQVLHSE EVPLLYLGRV HWRVNPSRTP GGRHRVSEEQ
260 270 280 290 300
WPHTWGPFPP YASGTGYVLS ASAVQLILKV ASRAPLLPLE DVFVGVSARR
310 320 330 340 350
GGLAPTQCVK LAGATHYPLD RCCYGKFLLT SHRLDPWKMQ EAWKLVGGSD
360 370
GERTAPFCSW FQGVLGILRC RAIAWLQS
Length:378
Mass (Da):41,537
Last modified:May 1, 1999 - v1
Checksum:i4E55DFC72AE96213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15061 mRNA. Translation: CAA75345.1.
AL031228 Genomic DNA. Translation: CAA20230.1.
AB026730 mRNA. Translation: BAA88988.1.
BC032574 mRNA. Translation: AAH32574.1.
CCDSiCCDS34425.1.
RefSeqiNP_003773.1. NM_003782.3.
UniGeneiHs.534375.

Genome annotation databases

EnsembliENST00000383209; ENSP00000372696; ENSG00000206285.
ENST00000415322; ENSP00000394876; ENSG00000226936.
ENST00000419471; ENSP00000398660; ENSG00000235155.
ENST00000430971; ENSP00000414880; ENSG00000236802.
ENST00000451237; ENSP00000390784; ENSG00000235863.
GeneIDi8705.
KEGGihsa:8705.

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15061 mRNA. Translation: CAA75345.1.
AL031228 Genomic DNA. Translation: CAA20230.1.
AB026730 mRNA. Translation: BAA88988.1.
BC032574 mRNA. Translation: AAH32574.1.
CCDSiCCDS34425.1.
RefSeqiNP_003773.1. NM_003782.3.
UniGeneiHs.534375.

3D structure databases

ProteinModelPortaliO96024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114248. 3 interactions.
IntActiO96024. 4 interactions.
MINTiMINT-1387639.
STRINGi9606.ENSP00000390784.

Chemistry

SwissLipidsiSLP:000000772.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

iPTMnetiO96024.
PhosphoSiteiO96024.

Polymorphism and mutation databases

BioMutaiB3GALT4.

Proteomic databases

PaxDbiO96024.
PRIDEiO96024.

Protocols and materials databases

DNASUi8705.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383209; ENSP00000372696; ENSG00000206285.
ENST00000415322; ENSP00000394876; ENSG00000226936.
ENST00000419471; ENSP00000398660; ENSG00000235155.
ENST00000430971; ENSP00000414880; ENSG00000236802.
ENST00000451237; ENSP00000390784; ENSG00000235863.
GeneIDi8705.
KEGGihsa:8705.

Organism-specific databases

CTDi8705.
GeneCardsiB3GALT4.
HGNCiHGNC:919. B3GALT4.
HPAiHPA043001.
MIMi603095. gene.
neXtProtiNX_O96024.
PharmGKBiPA25212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
HOGENOMiHOG000064523.
HOVERGENiHBG050651.
InParanoidiO96024.
KOiK00715.
OMAiPFCSWLQ.
OrthoDBiEOG76MK8S.
PhylomeDBiO96024.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.62. 2681.

Miscellaneous databases

GeneWikiiB3GALT4.
GenomeRNAii8705.
PROiO96024.
SOURCEiSearch...

Gene expression databases

BgeeiO96024.
CleanExiHS_B3GALT4.
ExpressionAtlasiO96024. baseline and differential.
GenevisibleiO96024. HS.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 2 hits.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family."
    Amado M., Almeida R., Carneiro F., Levery S.B., Holmes E.H., Nomoto M., Hollingsworth M.A., Hassan H., Schwientek T., Nielsen P.A., Bennett E.P., Clausen H.
    J. Biol. Chem. 273:12770-12778(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "The beta 1,3-galactosyltransferase-4 (b3Gal-T4) gene is located in the centromeric segment of the human MHC class II region."
    Shiina T., Kikkawa E., Iwasaki H., Kaneko M., Narimatsu H., Sasaki K., Bahram S., Inoko H.
    Immunogenetics 51:75-78(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.

Entry informationi

Entry nameiB3GT4_HUMAN
AccessioniPrimary (citable) accession number: O96024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.