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Protein

Beta-1,3-galactosyltransferase 4

Gene

B3GALT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in GM1/GD1B/GA1 ganglioside biosynthesis.1 Publication

Catalytic activityi

UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • ganglioside biosynthetic process Source: BHF-UCL
  • protein glycosylation Source: UniProtKB-UniPathway

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.62. 2681.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Chemistry databases

SwissLipidsiSLP:000000772.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 4 (EC:2.4.1.621 Publication)
Short name:
Beta-1,3-GalTase 4
Short name:
Beta3Gal-T4
Short name:
Beta3GalT4
Short name:
GalT4
Short name:
b3Gal-T4
Alternative name(s):
Gal-T2
Ganglioside galactosyltransferase
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
Gene namesi
Name:B3GALT4
Synonyms:GALT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000235863.3.
HGNCiHGNC:919. B3GALT4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 19Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST11
Topological domaini20 – 378LumenalSequence analysisAdd BLAST359

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8705.
OpenTargetsiENSG00000235863.
PharmGKBiPA25212.

Polymorphism and mutation databases

BioMutaiB3GALT4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191601 – 378Beta-1,3-galactosyltransferase 4Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO96024.
PeptideAtlasiO96024.
PRIDEiO96024.

PTM databases

iPTMnetiO96024.
PhosphoSitePlusiO96024.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain, placenta, kidney, liver and lung.2 Publications

Gene expression databases

BgeeiENSG00000235863.
CleanExiHS_B3GALT4.
ExpressionAtlasiO96024. baseline and differential.
GenevisibleiO96024. HS.

Organism-specific databases

HPAiHPA043001.

Interactioni

Protein-protein interaction databases

BioGridi114248. 3 interactors.
IntActiO96024. 4 interactors.
MINTiMINT-1387639.
STRINGi9606.ENSP00000390784.

Structurei

3D structure databases

ProteinModelPortaliO96024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000064523.
HOVERGENiHBG050651.
InParanoidiO96024.
KOiK00715.
OMAiPFCSWLQ.
OrthoDBiEOG091G0AXM.
PhylomeDBiO96024.
TreeFamiTF318639.

Family and domain databases

InterProiView protein in InterPro
IPR002659. Glyco_trans_31.
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiView protein in Pfam
PF01762. Galactosyl_T. 1 hit.

Sequencei

Sequence statusi: Complete.

O96024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLRLFRRLL LAALLLVIVW TLFGPSGLGE ELLSLSLASL LPAPASPGPP
60 70 80 90 100
LALPRLLIPN QEACSGPGAP PFLLILVCTA PENLNQRNAI RASWGGLREA
110 120 130 140 150
RGLRVQTLFL LGEPNAQHPV WGSQGSDLAS ESAAQGDILQ AAFQDSYRNL
160 170 180 190 200
TLKTLSGLNW AEKHCPMARY VLKTDDDVYV NVPELVSELV LRGGRWGQWE
210 220 230 240 250
RSTEPQREAE QEGGQVLHSE EVPLLYLGRV HWRVNPSRTP GGRHRVSEEQ
260 270 280 290 300
WPHTWGPFPP YASGTGYVLS ASAVQLILKV ASRAPLLPLE DVFVGVSARR
310 320 330 340 350
GGLAPTQCVK LAGATHYPLD RCCYGKFLLT SHRLDPWKMQ EAWKLVGGSD
360 370
GERTAPFCSW FQGVLGILRC RAIAWLQS
Length:378
Mass (Da):41,537
Last modified:May 1, 1999 - v1
Checksum:i4E55DFC72AE96213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15061 mRNA. Translation: CAA75345.1.
AL031228 Genomic DNA. Translation: CAA20230.1.
AB026730 mRNA. Translation: BAA88988.1.
BC032574 mRNA. Translation: AAH32574.1.
CCDSiCCDS34425.1.
RefSeqiNP_003773.1. NM_003782.3.
UniGeneiHs.534375.

Genome annotation databases

EnsembliENST00000383209; ENSP00000372696; ENSG00000206285.
ENST00000415322; ENSP00000394876; ENSG00000226936.
ENST00000419471; ENSP00000398660; ENSG00000235155.
ENST00000430971; ENSP00000414880; ENSG00000236802.
ENST00000451237; ENSP00000390784; ENSG00000235863.
GeneIDi8705.
KEGGihsa:8705.

Similar proteinsi

Entry informationi

Entry nameiB3GT4_HUMAN
AccessioniPrimary (citable) accession number: O96024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families