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Protein

G1/S-specific cyclin-E2

Gene

CCNE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the late G1 and early S phase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-1538133 G0 and Early G1
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
SignaLinkiO96020
SIGNORiO96020

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E2
Gene namesi
Name:CCNE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000175305.16
HGNCiHGNC:1590 CCNE2
MIMi603775 gene
neXtProtiNX_O96020

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi392T → A: Increase of steady state level. 1 Publication1

Organism-specific databases

DisGeNETi9134
OpenTargetsiENSG00000175305
PharmGKBiPA26155

Chemistry databases

ChEMBLiCHEMBL2094126

Polymorphism and mutation databases

BioMutaiCCNE2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804611 – 404G1/S-specific cyclin-E2Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei392PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO96020
PaxDbiO96020
PeptideAtlasiO96020
PRIDEiO96020

PTM databases

iPTMnetiO96020
PhosphoSitePlusiO96020

Expressioni

Tissue specificityi

According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

Inductioni

Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.

Gene expression databases

BgeeiENSG00000175305
CleanExiHS_CCNE2
ExpressionAtlasiO96020 baseline and differential
GenevisibleiO96020 HS

Organism-specific databases

HPAiCAB007825
CAB019374

Interactioni

Subunit structurei

Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114582, 14 interactors
DIPiDIP-31733N
IntActiO96020, 11 interactors
MINTiO96020
STRINGi9606.ENSP00000309181

Chemistry databases

BindingDBiO96020

Structurei

3D structure databases

ProteinModelPortaliO96020
SMRiO96020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiKOG0655 Eukaryota
ENOG410XS2J LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000231743
HOVERGENiHBG050834
InParanoidiO96020
KOiK06626
OMAiISPCIII
OrthoDBiEOG091G0DAW
PhylomeDBiO96020
TreeFamiTF101005

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR028858 Cyclin_E
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF70 PTHR10177:SF70, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O96020-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH
60 70 80 90 100
QYEIRNCWPP VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS
110 120 130 140 150
PLPDLSWGCS KEVWLNMLKK ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL
160 170 180 190 200
EVCEVYTLHR ETFYLAQDFF DRFMLTQKDI NKNMLQLIGI TSLFIASKLE
210 220 230 240 250
EIYAPKLQEF AYVTDGACSE EDILRMELII LKALKWELCP VTIISWLNLF
260 270 280 290 300
LQVDALKDAP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILTAAA
310 320 330 340 350
LCHFTSIEVV KKASGLEWDS ISECVDWMVP FVNVVKSTSP VKLKTFKKIP
360 370 380 390 400
MEDRHNIQTH TNYLAMLEEV NYINTFRKGG QLSPVCNGGI MTPPKSTEKP

PGKH
Length:404
Mass (Da):46,757
Last modified:May 1, 1999 - v1
Checksum:iD7DC9BEEF3FD62EC
GO
Isoform Short (identifier: O96020-2) [UniParc]FASTAAdd to basket
Also known as: SV

The sequence of this isoform differs from the canonical sequence as follows:
     167-211: Missing.

Show »
Length:359
Mass (Da):41,465
Checksum:i2A774B409828EC47
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021347387N → S1 PublicationCorresponds to variant dbSNP:rs28399585Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001256167 – 211Missing in isoform Short. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106690 mRNA Translation: AAD08816.1
AF112857 mRNA Translation: AAD08819.1
AF091433 mRNA Translation: AAC80528.1
AF102778 mRNA Translation: AAC78145.1
AY850195 Genomic DNA Translation: AAV97813.1
CCDSiCCDS6264.1 [O96020-1]
RefSeqiNP_477097.1, NM_057749.2 [O96020-1]
XP_016869446.1, XM_017013957.1 [O96020-1]
XP_016869447.1, XM_017013958.1 [O96020-1]
XP_016869448.1, XM_017013959.1 [O96020-1]
UniGeneiHs.521693

Genome annotation databases

EnsembliENST00000308108; ENSP00000309181; ENSG00000175305 [O96020-1]
ENST00000520509; ENSP00000429089; ENSG00000175305 [O96020-1]
GeneIDi9134
KEGGihsa:9134
UCSCiuc003yhc.4 human [O96020-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCNE2_HUMAN
AccessioniPrimary (citable) accession number: O96020
Secondary accession number(s): O95439
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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