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O96019

- ACL6A_HUMAN

UniProt

O96019 - ACL6A_HUMAN

Protein

Actin-like protein 6A

Gene

ACTL6A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.By similarity2 Publications

    GO - Molecular functioni

    1. chromatin binding Source: ProtInc
    2. protein binding Source: IntAct
    3. transcription coactivator activity Source: BHF-UCL

    GO - Biological processi

    1. ATP-dependent chromatin remodeling Source: UniProt
    2. chromatin organization Source: Reactome
    3. chromatin remodeling Source: BHF-UCL
    4. DNA recombination Source: UniProtKB-KW
    5. DNA repair Source: UniProtKB-KW
    6. histone H2A acetylation Source: UniProtKB
    7. histone H4 acetylation Source: UniProtKB
    8. nervous system development Source: UniProtKB-KW
    9. neural retina development Source: BHF-UCL
    10. regulation of growth Source: UniProtKB-KW
    11. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    12. signal transduction Source: ProtInc
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, Growth regulation, Neurogenesis, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.
    REACT_197820. HATs acetylate histones.
    SignaLinkiO96019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-like protein 6A
    Alternative name(s):
    53 kDa BRG1-associated factor A
    Actin-related protein Baf53a
    ArpNbeta
    BRG1-associated factor 53A
    Short name:
    BAF53A
    INO80 complex subunit K
    Gene namesi
    Name:ACTL6A
    Synonyms:BAF53, BAF53A, INO80K
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24124. ACTL6A.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Ino80 complex Source: UniProtKB
    2. npBAF complex Source: UniProtKB
    3. NuA4 histone acetyltransferase complex Source: UniProtKB
    4. nuclear chromatin Source: UniProt
    5. nucleoplasm Source: Reactome
    6. nucleus Source: UniProtKB
    7. plasma membrane Source: LIFEdb
    8. protein complex Source: UniProt
    9. SWI/SNF complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914203.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 429428Actin-like protein 6APRO_0000089133Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei233 – 2331Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO96019.
    PaxDbiO96019.
    PeptideAtlasiO96019.
    PRIDEiO96019.

    PTM databases

    PhosphoSiteiO96019.

    Miscellaneous databases

    PMAP-CutDBO96019.

    Expressioni

    Gene expression databases

    ArrayExpressiO96019.
    BgeeiO96019.
    CleanExiHS_ACTL6A.
    GenevestigatoriO96019.

    Organism-specific databases

    HPAiCAB012188.

    Interactioni

    Subunit structurei

    Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM/BAF190B, and TRRAP/PAF400, and which may also include a HAT activity related to, but distinct from, that of KAT5. ACTL6A interacts with SMARCA4/BRG1/BAF190A. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Interacts with PHF10/BAF45A By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YY1P254905EBI-355018,EBI-765538

    Protein-protein interaction databases

    BioGridi106601. 63 interactions.
    DIPiDIP-27565N.
    IntActiO96019. 52 interactions.
    MINTiMINT-1136373.
    STRINGi9606.ENSP00000397552.

    Structurei

    3D structure databases

    ProteinModelPortaliO96019.
    SMRiO96019. Positions 8-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Phylogenomic databases

    eggNOGiCOG5277.
    HOGENOMiHOG000233340.
    HOVERGENiHBG003771.
    InParanoidiO96019.
    KOiK11340.
    OMAiGYHQDFG.
    OrthoDBiEOG7JT6W3.
    PhylomeDBiO96019.
    TreeFamiTF312863.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR004001. Actin_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS00432. ACTINS_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O96019-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG    50
    STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLKN GMVEDWDSFQ 100
    AILDHTYKMH VKSEASLHPV LMSEAPWNTR AKREKLTELM FEHYNIPAFF 150
    LCKTAVLTAF ANGRSTGLIL DSGATHTTAI PVHDGYVLQQ GIVKSPLAGD 200
    FITMQCRELF QEMNIELVPP YMIASKEAVR EGSPANWKRK EKLPQVTRSW 250
    HNYMCNCVIQ DFQASVLQVS DSTYDEQVAA QMPTVHYEFP NGYNCDFGAE 300
    RLKIPEGLFD PSNVKGLSGN TMLGVSHVVT TSVGMCDIDI RPGLYGSVIV 350
    AGGNTLIQSF TDRLNRELSQ KTPPSMRLKL IANNTTVERR FSSWIGGSIL 400
    ASLGTFQQMW ISKQEYEEGG KQCVERKCP 429
    Length:429
    Mass (Da):47,461
    Last modified:May 1, 1999 - v1
    Checksum:iECD92D29BD1854E0
    GO
    Isoform 2 (identifier: O96019-2) [UniParc]FASTAAdd to Basket

    Also known as: HArpNbeta-s

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.

    Show »
    Length:387
    Mass (Da):43,236
    Checksum:i5FF2B5B41C15C03A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921M → T in CAB66543. (PubMed:11230166)Curated
    Sequence conflicti210 – 2101F → L in CAB66543. (PubMed:11230166)Curated
    Sequence conflicti254 – 2541M → T in CAB66543. (PubMed:11230166)Curated
    Sequence conflicti320 – 3201N → K in CAB66543. (PubMed:11230166)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_000150Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041474 mRNA. Translation: AAC94991.1.
    AB015907 mRNA. Translation: BAA74577.1.
    AB060168 mRNA. Translation: BAB87844.1.
    AB061315 mRNA. Translation: BAB87848.1.
    AL136608 mRNA. Translation: CAB66543.1.
    AK021756 mRNA. Translation: BAG51043.1.
    CH471052 Genomic DNA. Translation: EAW78401.1.
    CH471052 Genomic DNA. Translation: EAW78397.1.
    CH471052 Genomic DNA. Translation: EAW78399.1.
    BC000949 mRNA. Translation: AAH00949.1.
    BC001391 mRNA. Translation: AAH01391.1.
    BC036371 mRNA. Translation: AAH36371.1.
    CCDSiCCDS3231.1. [O96019-1]
    CCDS43174.1. [O96019-2]
    RefSeqiNP_004292.1. NM_004301.3. [O96019-1]
    NP_817126.1. NM_177989.2. [O96019-2]
    NP_829888.1. NM_178042.2. [O96019-2]
    UniGeneiHs.435326.

    Genome annotation databases

    EnsembliENST00000392662; ENSP00000376430; ENSG00000136518. [O96019-2]
    ENST00000429709; ENSP00000397552; ENSG00000136518. [O96019-1]
    ENST00000450518; ENSP00000394014; ENSG00000136518. [O96019-2]
    GeneIDi86.
    KEGGihsa:86.
    UCSCiuc003fjw.3. human. [O96019-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041474 mRNA. Translation: AAC94991.1 .
    AB015907 mRNA. Translation: BAA74577.1 .
    AB060168 mRNA. Translation: BAB87844.1 .
    AB061315 mRNA. Translation: BAB87848.1 .
    AL136608 mRNA. Translation: CAB66543.1 .
    AK021756 mRNA. Translation: BAG51043.1 .
    CH471052 Genomic DNA. Translation: EAW78401.1 .
    CH471052 Genomic DNA. Translation: EAW78397.1 .
    CH471052 Genomic DNA. Translation: EAW78399.1 .
    BC000949 mRNA. Translation: AAH00949.1 .
    BC001391 mRNA. Translation: AAH01391.1 .
    BC036371 mRNA. Translation: AAH36371.1 .
    CCDSi CCDS3231.1. [O96019-1 ]
    CCDS43174.1. [O96019-2 ]
    RefSeqi NP_004292.1. NM_004301.3. [O96019-1 ]
    NP_817126.1. NM_177989.2. [O96019-2 ]
    NP_829888.1. NM_178042.2. [O96019-2 ]
    UniGenei Hs.435326.

    3D structure databases

    ProteinModelPortali O96019.
    SMRi O96019. Positions 8-428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106601. 63 interactions.
    DIPi DIP-27565N.
    IntActi O96019. 52 interactions.
    MINTi MINT-1136373.
    STRINGi 9606.ENSP00000397552.

    PTM databases

    PhosphoSitei O96019.

    Proteomic databases

    MaxQBi O96019.
    PaxDbi O96019.
    PeptideAtlasi O96019.
    PRIDEi O96019.

    Protocols and materials databases

    DNASUi 86.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392662 ; ENSP00000376430 ; ENSG00000136518 . [O96019-2 ]
    ENST00000429709 ; ENSP00000397552 ; ENSG00000136518 . [O96019-1 ]
    ENST00000450518 ; ENSP00000394014 ; ENSG00000136518 . [O96019-2 ]
    GeneIDi 86.
    KEGGi hsa:86.
    UCSCi uc003fjw.3. human. [O96019-1 ]

    Organism-specific databases

    CTDi 86.
    GeneCardsi GC03P179280.
    HGNCi HGNC:24124. ACTL6A.
    HPAi CAB012188.
    MIMi 604958. gene.
    neXtProti NX_O96019.
    PharmGKBi PA134914203.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5277.
    HOGENOMi HOG000233340.
    HOVERGENi HBG003771.
    InParanoidi O96019.
    KOi K11340.
    OMAi GYHQDFG.
    OrthoDBi EOG7JT6W3.
    PhylomeDBi O96019.
    TreeFami TF312863.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.
    REACT_197820. HATs acetylate histones.
    SignaLinki O96019.

    Miscellaneous databases

    ChiTaRSi ACTL6A. human.
    GeneWikii ACTL6A.
    GenomeRNAii 86.
    NextBioi 315.
    PMAP-CutDB O96019.
    PROi O96019.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O96019.
    Bgeei O96019.
    CleanExi HS_ACTL6A.
    Genevestigatori O96019.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR004001. Actin_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00432. ACTINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling."
      Zhao K., Wang W., Rando O.J., Xue Y., Swiderek K., Kuo A., Crabtree G.R.
      Cell 95:625-636(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN BAF COMPLEX.
    2. "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues."
      Harata M., Mochizuki R., Mizuno S.
      Biosci. Biotechnol. Biochem. 63:917-923(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Characterization of an alternative splicing product of hArpNbeta/BAF53."
      Harata M., Ohfuchi E.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta, Skin and Testis.
    8. Bienvenut W.V.
      Submitted (JAN-2010) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-24; 63-76; 113-130; 195-207 AND 380-389, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    9. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."
      Cai Y., Jin J., Tomomori-Sato C., Sato S., Sorokina I., Parmely T.J., Conaway R.C., Conaway J.W.
      J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 35-60; 63-76; 113-130; 154-164; 195-207; 304-315 AND 380-389, IDENTIFICATION IN NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis."
      Ikura T., Ogryzko V.V., Grigoriev M., Groisman R., Wang J., Horikoshi M., Scully R., Qin J., Nakatani Y.
      Cell 102:463-473(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    11. Cited for: IDENTIFICATION IN NUA4-LIKE COMPLEX.
    12. "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation."
      Park J., Wood M.A., Cole M.D.
      Mol. Cell. Biol. 22:1307-1316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BAF53 COMPLEX WITH RUVBL1; SMARCA2 AND TRRAP.
    13. "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome."
      Kitagawa H., Fujiki R., Yoshimura K., Mezaki Y., Uematsu Y., Matsui D., Ogawa S., Unno K., Okubo M., Tokita A., Nakagawa T., Ito T., Ishimi Y., Nagasawa H., Matsumoto T., Yanagisawa J., Kato S.
      Cell 113:905-917(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE WINAC COMPLEX, FUNCTION.
    14. "The highly conserved and multifunctional NuA4 HAT complex."
      Doyon Y., Cote J.
      Curr. Opin. Genet. Dev. 14:147-154(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON NUA4 COMPLEX.
    15. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."
      Doyon Y., Selleck W., Lane W.S., Tan S., Cote J.
      Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN NUA4 COMPLEX, IDENTIFICATION IN A NUA4-RELATED SRCAP-CONTAINING COMPLEX.
    16. Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."
      Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y.
      Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH THE INO80 COMPLEX.
    19. "Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex."
      Lange M., Kaynak B., Forster U.B., Toenjes M., Fischer J.J., Grimm C., Schlesinger J., Just S., Dunkel I., Krueger T., Mebus S., Lehrach H., Lurz R., Gobom J., Rottbauer W., Abdelilah-Seyfried S., Sperling S.
      Genes Dev. 22:2370-2384(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BAF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    20. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
      Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W.
      Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
      Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.
      J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX.
    24. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiACL6A_HUMAN
    AccessioniPrimary (citable) accession number: O96019
    Secondary accession number(s): B3KMN1
    , D3DNR9, Q8TAE5, Q9BVS8, Q9H0W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3