Reviewed,
UniProtKB/Swiss-Prot O96018 (APBA3_HUMAN)
Last modified
November 24, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Amyloid beta A4 precursor protein-binding family A member 3 Alternative name(s): Neuron-specific X11L2 protein Neuronal Munc18-1-interacting protein 3 Short name=Mint-3 Adapter protein X11gamma | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 575 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. |
| Subunit structure | Binds to the cytoplasmic domain of amyloid protein (APP) in vivo. |
| Tissue specificity | Expressed in all the tissues examined with lower levels in brain and testis. |
| Domain | Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane. |
| Sequence similarities | Contains 2 PDZ (DHR) domains. Contains 1 PID domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | intracellular signaling cascade Non-traceable author statement. Source: UniProtKB protein transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | membrane Non-traceable author statement. Source: UniProtKB |
| Molecular function | protein binding Ref.1 Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 575 | 575 | Amyloid beta A4 precursor protein-binding family A member 3 | PRO_0000064620 | |||||||||||||||||||||
Regions | |||||||||||||||||||||||||
| Domain | 217 – 381 | 165 | PID | ||||||||||||||||||||||
| Domain | 394 – 480 | 87 | PDZ 1 | ||||||||||||||||||||||
| Domain | 485 – 560 | 76 | PDZ 2 | ||||||||||||||||||||||
| Compositional bias | 165 – 171 | 7 | Poly-Ser | ||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||
| Modified residue | 9 | 1 | Phosphoserine Ref.5 | ||||||||||||||||||||||
| Modified residue | 372 | 1 | Phosphoserine Ref.5 Ref.6 | ||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||
| Natural variant | 154 | 1 | W → L: dbSNP rs35932323. | VAR_050666 | |||||||||||||||||||||
| Natural variant | 276 | 1 | K → T: dbSNP rs3746119. | VAR_020134 | |||||||||||||||||||||
| Natural variant | 376 | 1 | C → R: dbSNP rs8102086. | VAR_047952 | |||||||||||||||||||||
| Natural variant | 527 | 1 | I → F: dbSNP rs1045236. | VAR_011822 | |||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||
| Sequence conflict | 505 | 1 | I → IVRPRPLAPGWGGRAALSTA PEQPPPLSRAPLFLPQ in AAC17979. Ref.4 | ||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||
| Beta strand | 393 – 398 | 6 | |||||||||||||||||||||||
| Beta strand | 407 – 411 | 5 | |||||||||||||||||||||||
| Beta strand | 415 – 418 | 4 | |||||||||||||||||||||||
| Beta strand | 421 – 426 | 6 | |||||||||||||||||||||||
| Helix | 433 – 435 | 3 | |||||||||||||||||||||||
| Beta strand | 443 – 449 | 7 | |||||||||||||||||||||||
| Helix | 457 – 466 | 10 | |||||||||||||||||||||||
| Turn | 467 – 469 | 3 | |||||||||||||||||||||||
| Beta strand | 470 – 477 | 8 | |||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "X11L2, a new member of X11 protein family interacts with Alzheimer's beta-amyloid precursor protein." Tanahashi H., Tabira T. Biochem. Biophys. Res. Commun. 255:663-667(1999) [PubMed: 10049767] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [4] | "Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2." Okamoto M., Suedhof T.C. Eur. J. Cell Biol. 77:161-165(1998) [PubMed: 9860131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 472-575. |
| [5] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-372, MASS SPECTROMETRY. |
| [6] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, MASS SPECTROMETRY. |
| [7] | "Solution structure of the PDZ domain of amyloid beta A4 precursor protein-binding family A member 3." RIKEN structural genomics initiative (RSGI) Submitted (APR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 387-569. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AB021638 mRNA. Translation: BAA74430.1. AC005954 Genomic DNA. Translation: AAC72275.1. BC086306 mRNA. Translation: AAH86306.1. AF029110 mRNA. Translation: AAC17979.1. | |||||||||||||||||||
| IPI | IPI00014073. | ||||||||||||||||||
| PIR | JG0181. | ||||||||||||||||||
| RefSeq | NP_004877.1. | ||||||||||||||||||
| UniGene | Hs.25527 Hs.465607 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| STRING | O96018. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | O96018. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | O96018. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000316757; ENSP00000315136; ENSG00000011132; Homo sapiens. [Genome view] | ||||||||||||||||||
| GeneID | 9546. | ||||||||||||||||||
| KEGG | hsa:9546. | ||||||||||||||||||
| UCSC | uc002lyp.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 9546. | ||||||||||||||||||
| GeneCards | GC19M003701. | ||||||||||||||||||
| H-InvDB | HIX0039924. | ||||||||||||||||||
| HGNC | HGNC:580. APBA3. | ||||||||||||||||||
| MIM | 604262. gene. | ||||||||||||||||||
| PharmGKB | PA24872. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | O96018. | ||||||||||||||||||
| HOVERGEN | O96018. | ||||||||||||||||||
| OMA | GAPCPLH | ||||||||||||||||||
| OrthoDB | EOG96HJW0 | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| Bgee | O96018. | ||||||||||||||||||
| CleanEx | HS_APBA3. | ||||||||||||||||||
| Genevestigator | O96018. | ||||||||||||||||||
| GermOnline | ENSG00000011132. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR001478. PDZ/DHR/GLGF. IPR011993. PH_type. IPR006020. PTB_PID. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:2.30.29.30. PH_type. 1 hit. | ||||||||||||||||||
| Pfam | PF00595. PDZ. 2 hits. PF00640. PID. 1 hit. [Graphical view] | ||||||||||||||||||
| SMART | SM00228. PDZ. 2 hits. SM00462. PTB. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS50106. PDZ. 2 hits. PS01179. PID. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 35799. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | APBA3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O96018 Secondary accession number(s): O60483 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


