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O96015

- DNAL4_HUMAN

UniProt

O96015 - DNAL4_HUMAN

Protein

Dynein light chain 4, axonemal

Gene

DNAL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity By similarity.By similarity

    GO - Molecular functioni

    1. motor activity Source: UniProtKB-KW

    GO - Biological processi

    1. microtubule-based process Source: InterPro
    2. neurotrophin TRK receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Motor protein

    Enzyme and pathway databases

    ReactomeiREACT_12435. Retrograde neurotrophin signalling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynein light chain 4, axonemal
    Gene namesi
    Name:DNAL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:2955. DNAL4.

    Subcellular locationi

    Cytoplasmcytoskeletoncilium axoneme By similarity

    GO - Cellular componenti

    1. cilium Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-KW
    3. dynein complex Source: UniProtKB-KW
    4. microtubule Source: UniProtKB-KW
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27426.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 105105Dynein light chain 4, axonemalPRO_0000195136Add
    BLAST

    Proteomic databases

    MaxQBiO96015.
    PaxDbiO96015.
    PRIDEiO96015.

    Expressioni

    Gene expression databases

    ArrayExpressiO96015.
    BgeeiO96015.
    CleanExiHS_DNAL4.
    GenevestigatoriO96015.

    Organism-specific databases

    HPAiHPA003647.

    Interactioni

    Subunit structurei

    Consists of at least two heavy chains and a number of intermediate and light chains.

    Protein-protein interaction databases

    BioGridi115430. 4 interactions.
    IntActiO96015. 4 interactions.
    MINTiMINT-1474007.
    STRINGi9606.ENSP00000216068.

    Structurei

    3D structure databases

    ProteinModelPortaliO96015.
    SMRiO96015. Positions 21-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dynein light chain family.Curated

    Phylogenomic databases

    eggNOGiNOG286480.
    HOGENOMiHOG000211145.
    HOVERGENiHBG104642.
    InParanoidiO96015.
    KOiK10412.
    OMAiTACEKYS.
    PhylomeDBiO96015.
    TreeFamiTF324136.

    Family and domain databases

    Gene3Di3.30.740.10. 1 hit.
    InterProiIPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view]
    PANTHERiPTHR11886. PTHR11886. 1 hit.
    PfamiPF01221. Dynein_light. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O96015-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN    50
    ESAAKMIKET MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC 100
    VWKCS 105
    Length:105
    Mass (Da):12,009
    Last modified:May 1, 1999 - v1
    Checksum:iD0AE8929DEB2AC06
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581K → N in CAG46992. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035366 mRNA. Translation: CAA23018.1.
    BT009847 mRNA. Translation: AAP88849.1.
    AY453399 mRNA. Translation: AAS47516.1.
    CR456487 mRNA. Translation: CAG30373.1.
    AK290566 mRNA. Translation: BAF83255.1.
    CR542177 mRNA. Translation: CAG46974.1.
    CR542195 mRNA. Translation: CAG46992.1.
    AL008583 Genomic DNA. Translation: CAA15429.1.
    CH471095 Genomic DNA. Translation: EAW60272.1.
    BC002968 mRNA. Translation: AAH02968.1.
    CCDSiCCDS13979.1.
    RefSeqiNP_005731.1. NM_005740.2.
    UniGeneiHs.632766.

    Genome annotation databases

    EnsembliENST00000216068; ENSP00000216068; ENSG00000100246.
    GeneIDi10126.
    KEGGihsa:10126.
    UCSCiuc003awj.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035366 mRNA. Translation: CAA23018.1 .
    BT009847 mRNA. Translation: AAP88849.1 .
    AY453399 mRNA. Translation: AAS47516.1 .
    CR456487 mRNA. Translation: CAG30373.1 .
    AK290566 mRNA. Translation: BAF83255.1 .
    CR542177 mRNA. Translation: CAG46974.1 .
    CR542195 mRNA. Translation: CAG46992.1 .
    AL008583 Genomic DNA. Translation: CAA15429.1 .
    CH471095 Genomic DNA. Translation: EAW60272.1 .
    BC002968 mRNA. Translation: AAH02968.1 .
    CCDSi CCDS13979.1.
    RefSeqi NP_005731.1. NM_005740.2.
    UniGenei Hs.632766.

    3D structure databases

    ProteinModelPortali O96015.
    SMRi O96015. Positions 21-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115430. 4 interactions.
    IntActi O96015. 4 interactions.
    MINTi MINT-1474007.
    STRINGi 9606.ENSP00000216068.

    Proteomic databases

    MaxQBi O96015.
    PaxDbi O96015.
    PRIDEi O96015.

    Protocols and materials databases

    DNASUi 10126.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216068 ; ENSP00000216068 ; ENSG00000100246 .
    GeneIDi 10126.
    KEGGi hsa:10126.
    UCSCi uc003awj.3. human.

    Organism-specific databases

    CTDi 10126.
    GeneCardsi GC22M039174.
    HGNCi HGNC:2955. DNAL4.
    HPAi HPA003647.
    MIMi 610565. gene.
    neXtProti NX_O96015.
    PharmGKBi PA27426.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286480.
    HOGENOMi HOG000211145.
    HOVERGENi HBG104642.
    InParanoidi O96015.
    KOi K10412.
    OMAi TACEKYS.
    PhylomeDBi O96015.
    TreeFami TF324136.

    Enzyme and pathway databases

    Reactomei REACT_12435. Retrograde neurotrophin signalling.

    Miscellaneous databases

    GeneWikii DNAL4.
    GenomeRNAii 10126.
    NextBioi 38303.
    PROi O96015.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O96015.
    Bgeei O96015.
    CleanExi HS_DNAL4.
    Genevestigatori O96015.

    Family and domain databases

    Gene3Di 3.30.740.10. 1 hit.
    InterProi IPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view ]
    PANTHERi PTHR11886. PTHR11886. 1 hit.
    Pfami PF01221. Dynein_light. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
      Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
      Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Identification of a human proliferation inducing gene."
      Kim J.W.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiDNAL4_HUMAN
    AccessioniPrimary (citable) accession number: O96015
    Secondary accession number(s): Q6FGB2, Q6FGD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3