O96015 (DNAL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein light chain 4, axonemal

Gene names

Name:

DNAL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity By similarity.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme By similarity.
Sequence similarities	Belongs to the dynein light chain family.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Non-traceable author statement. Source: UniProtKB neurotrophin TRK receptor signaling pathway Traceable author statement. Source: Reactome
Cellular_component	axonemal dynein complex Non-traceable author statement. Source: UniProtKB cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	ATPase activity, coupled Non-traceable author statement. Source: UniProtKB microtubule motor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 105	105	Dynein light chain 4, axonemal		PRO_0000195136

Sequences

	Sequence		Length	Mass (Da)
	O96015 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: D0AE8929DEB2AC06	FASTA	105	12,009
	10 20 30 40 50 60 MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN ESAAKMIKET 70 80 90 100 MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC VWKCS

References

[1]	"Reevaluating human gene annotation: a second-generation analysis of chromosome 22." Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I. Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035366 mRNA. Translation: CAA23018.1. CR456487 mRNA. Translation: CAG30373.1. AL008583 Genomic DNA. Translation: CAA15429.1. BC002968 mRNA. Translation: AAH02968.1.
IPI	IPI00024734.
RefSeq	NP_005731.1. NM_005740.2.
UniGene	Hs.632766.
3D structure databases
ProteinModelPortal	O96015.
ModBase	Search...
Protein-protein interaction databases
IntAct	O96015. 4 interactions.
MINT	MINT-1474007.
STRING	9606.ENSP00000216068.
Proteomic databases
PaxDb	O96015.
PRIDE	O96015.
Protocols and materials databases
DNASU	10126.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216068; ENSP00000216068; ENSG00000100246.
GeneID	10126.
KEGG	hsa:10126.
UCSC	uc003awj.3. human.
Organism-specific databases
CTD	10126.
GeneCards	GC22M039174.
HGNC	HGNC:2955. DNAL4.
HPA	HPA003647.
MIM	610565. gene.
neXtProt	NX_O96015.
PharmGKB	PA27426.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286480.
HOGENOM	HOG000211145.
HOVERGEN	HBG104642.
InParanoid	O96015.
KO	K10412.
OMA	LIRHSDM.
OrthoDB	EOG4GF3GP.
PhylomeDB	O96015.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O96015.
Bgee	O96015.
CleanEx	HS_DNAL4.
Genevestigator	O96015.
GermOnline	ENSG00000100246. Homo sapiens.
Family and domain databases
Gene3D	3.30.740.10. 1 hit.
InterPro	IPR001372. Dynein_light_chain_typ-1/2. [Graphical view]
PANTHER	PTHR11886. PTHR11886. 1 hit.
Pfam	PF01221. Dynein_light. 1 hit. [Graphical view]
SUPFAM	SSF54648. Dynein_light_chain_typ-1/2. 1 hit.
PROSITE	PS01239. DYNEIN_LIGHT_1. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10126.
NextBio	38303.
SOURCE	Search...

Entry information

Entry name

DNAL4_HUMAN

Accession

Primary (citable) accession number: O96015

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.