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Protein

Dynein light chain 4, axonemal

Gene

DNAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-HSA-177504. Retrograde neurotrophin signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 4, axonemal
Gene namesi
Name:DNAL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100246.12.
HGNCiHGNC:2955. DNAL4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Involvement in diseasei

Mirror movements 3 (MRMV3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.
See also OMIM:616059

Organism-specific databases

DisGeNETi10126.
MalaCardsiDNAL4.
MIMi616059. phenotype.
OpenTargetsiENSG00000100246.
PharmGKBiPA27426.

Polymorphism and mutation databases

BioMutaiDNAL4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951361 – 105Dynein light chain 4, axonemalAdd BLAST105

Proteomic databases

EPDiO96015.
PaxDbiO96015.
PeptideAtlasiO96015.
PRIDEiO96015.

Expressioni

Gene expression databases

BgeeiENSG00000100246.
CleanExiHS_DNAL4.
ExpressionAtlasiO96015. baseline and differential.
GenevisibleiO96015. HS.

Organism-specific databases

HPAiHPA003647.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115430. 31 interactors.
IntActiO96015. 16 interactors.
MINTiMINT-1474007.
STRINGi9606.ENSP00000216068.

Structurei

3D structure databases

ProteinModelPortaliO96015.
SMRiO96015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOGENOMiHOG000211145.
HOVERGENiHBG104642.
InParanoidiO96015.
KOiK10412.
OMAiDMSEEMR.
OrthoDBiEOG091G0WT4.
PhylomeDBiO96015.
TreeFamiTF324136.

Family and domain databases

InterProiView protein in InterPro
IPR001372. Dynein_light_chain_typ-1/2.
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiView protein in Pfam
PF01221. Dynein_light. 1 hit.
SMARTiView protein in SMART
SM01375. Dynein_light. 1 hit.

Sequencei

Sequence statusi: Complete.

O96015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN
60 70 80 90 100
ESAAKMIKET MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC

VWKCS
Length:105
Mass (Da):12,009
Last modified:May 1, 1999 - v1
Checksum:iD0AE8929DEB2AC06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58K → N in CAG46992 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035366 mRNA. Translation: CAA23018.1.
BT009847 mRNA. Translation: AAP88849.1.
AY453399 mRNA. Translation: AAS47516.1.
CR456487 mRNA. Translation: CAG30373.1.
AK290566 mRNA. Translation: BAF83255.1.
CR542177 mRNA. Translation: CAG46974.1.
CR542195 mRNA. Translation: CAG46992.1.
AL008583 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW60272.1.
BC002968 mRNA. Translation: AAH02968.1.
CCDSiCCDS13979.1.
RefSeqiNP_005731.1. NM_005740.2.
UniGeneiHs.632766.

Genome annotation databases

EnsembliENST00000216068; ENSP00000216068; ENSG00000100246.
GeneIDi10126.
KEGGihsa:10126.
UCSCiuc003awj.4. human.

Similar proteinsi

Entry informationi

Entry nameiDNAL4_HUMAN
AccessioniPrimary (citable) accession number: O96015
Secondary accession number(s): Q6FGB2, Q6FGD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families