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O96015

- DNAL4_HUMAN

UniProt

O96015 - DNAL4_HUMAN

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Protein
Dynein light chain 4, axonemal
Gene
DNAL4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity By similarity.

GO - Molecular functioni

  1. motor activity Source: UniProtKB-KW

GO - Biological processi

  1. microtubule-based process Source: InterPro
  2. neurotrophin TRK receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Enzyme and pathway databases

ReactomeiREACT_12435. Retrograde neurotrophin signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 4, axonemal
Gene namesi
Name:DNAL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:2955. DNAL4.

Subcellular locationi

Cytoplasmcytoskeletoncilium axoneme By similarity

GO - Cellular componenti

  1. cilium Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. dynein complex Source: UniProtKB-KW
  4. microtubule Source: UniProtKB-KW
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Dynein light chain 4, axonemal
PRO_0000195136Add
BLAST

Proteomic databases

MaxQBiO96015.
PaxDbiO96015.
PRIDEiO96015.

Expressioni

Gene expression databases

ArrayExpressiO96015.
BgeeiO96015.
CleanExiHS_DNAL4.
GenevestigatoriO96015.

Organism-specific databases

HPAiHPA003647.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

BioGridi115430. 4 interactions.
IntActiO96015. 4 interactions.
MINTiMINT-1474007.
STRINGi9606.ENSP00000216068.

Structurei

3D structure databases

ProteinModelPortaliO96015.
SMRiO96015. Positions 21-94.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG286480.
HOGENOMiHOG000211145.
HOVERGENiHBG104642.
InParanoidiO96015.
KOiK10412.
OMAiTACEKYS.
PhylomeDBiO96015.
TreeFamiTF324136.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O96015-1 [UniParc]FASTAAdd to Basket

« Hide

MGETEGKKDE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN    50
ESAAKMIKET MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC 100
VWKCS 105
Length:105
Mass (Da):12,009
Last modified:May 1, 1999 - v1
Checksum:iD0AE8929DEB2AC06
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581K → N in CAG46992. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035366 mRNA. Translation: CAA23018.1.
BT009847 mRNA. Translation: AAP88849.1.
AY453399 mRNA. Translation: AAS47516.1.
CR456487 mRNA. Translation: CAG30373.1.
AK290566 mRNA. Translation: BAF83255.1.
CR542177 mRNA. Translation: CAG46974.1.
CR542195 mRNA. Translation: CAG46992.1.
AL008583 Genomic DNA. Translation: CAA15429.1.
CH471095 Genomic DNA. Translation: EAW60272.1.
BC002968 mRNA. Translation: AAH02968.1.
CCDSiCCDS13979.1.
RefSeqiNP_005731.1. NM_005740.2.
UniGeneiHs.632766.

Genome annotation databases

EnsembliENST00000216068; ENSP00000216068; ENSG00000100246.
GeneIDi10126.
KEGGihsa:10126.
UCSCiuc003awj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035366 mRNA. Translation: CAA23018.1 .
BT009847 mRNA. Translation: AAP88849.1 .
AY453399 mRNA. Translation: AAS47516.1 .
CR456487 mRNA. Translation: CAG30373.1 .
AK290566 mRNA. Translation: BAF83255.1 .
CR542177 mRNA. Translation: CAG46974.1 .
CR542195 mRNA. Translation: CAG46992.1 .
AL008583 Genomic DNA. Translation: CAA15429.1 .
CH471095 Genomic DNA. Translation: EAW60272.1 .
BC002968 mRNA. Translation: AAH02968.1 .
CCDSi CCDS13979.1.
RefSeqi NP_005731.1. NM_005740.2.
UniGenei Hs.632766.

3D structure databases

ProteinModelPortali O96015.
SMRi O96015. Positions 21-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115430. 4 interactions.
IntActi O96015. 4 interactions.
MINTi MINT-1474007.
STRINGi 9606.ENSP00000216068.

Proteomic databases

MaxQBi O96015.
PaxDbi O96015.
PRIDEi O96015.

Protocols and materials databases

DNASUi 10126.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216068 ; ENSP00000216068 ; ENSG00000100246 .
GeneIDi 10126.
KEGGi hsa:10126.
UCSCi uc003awj.3. human.

Organism-specific databases

CTDi 10126.
GeneCardsi GC22M039174.
HGNCi HGNC:2955. DNAL4.
HPAi HPA003647.
MIMi 610565. gene.
neXtProti NX_O96015.
PharmGKBi PA27426.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286480.
HOGENOMi HOG000211145.
HOVERGENi HBG104642.
InParanoidi O96015.
KOi K10412.
OMAi TACEKYS.
PhylomeDBi O96015.
TreeFami TF324136.

Enzyme and pathway databases

Reactomei REACT_12435. Retrograde neurotrophin signalling.

Miscellaneous databases

GeneWikii DNAL4.
GenomeRNAii 10126.
NextBioi 38303.
PROi O96015.
SOURCEi Search...

Gene expression databases

ArrayExpressi O96015.
Bgeei O96015.
CleanExi HS_DNAL4.
Genevestigatori O96015.

Family and domain databases

Gene3Di 3.30.740.10. 1 hit.
InterProi IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view ]
PANTHERi PTHR11886. PTHR11886. 1 hit.
Pfami PF01221. Dynein_light. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Identification of a human proliferation inducing gene."
    Kim J.W.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiDNAL4_HUMAN
AccessioniPrimary (citable) accession number: O96015
Secondary accession number(s): Q6FGB2, Q6FGD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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