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O96014 (WNT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-11
Gene names
Name:WNT11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas. Ref.2

Post-translational modification

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from expression pattern Ref.1. Source: UniProtKB

artery morphogenesis

Inferred from electronic annotation. Source: Ensembl

bone mineralization

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to retinoic acid

Inferred from sequence or structural similarity. Source: UniProtKB

cloacal septation

Inferred from expression pattern Ref.1. Source: UniProtKB

embryonic skeletal system development

Inferred from expression pattern Ref.1. Source: UniProtKB

lung-associated mesenchyme development

Inferred from expression pattern Ref.1. Source: UniProtKB

mesonephric duct development

Inferred from expression pattern Ref.1. Source: UniProtKB

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB

negative regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

negative regulation of cartilage development

Non-traceable author statement Ref.1. Source: UniProtKB

negative regulation of cell death

Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB

negative regulation of cell growth

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

negative regulation of cell migration

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

negative regulation of fibroblast growth factor production

Inferred from electronic annotation. Source: Ensembl

negative regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 20103596PubMed 20219091. Source: UniProtKB

neuroendocrine cell differentiation

Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

non-canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from mutant phenotype PubMed 18413325. Source: BHF-UCL

positive regulation of Ras GTPase activity

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB

positive regulation of gene expression

Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB

positive regulation of protein kinase C signaling

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

positive regulation of protein kinase activity

Inferred from mutant phenotype PubMed 20103596PubMed 20219091. Source: GOC

positive regulation of stress fiber assembly

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 19847889. Source: UniProtKB

positive regulation of transforming growth factor beta2 production

Inferred from electronic annotation. Source: Ensembl

protein localization to cell surface

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

protein phosphorylation

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

response to nutrient levels

Inferred from electronic annotation. Source: Ensembl

tight junction assembly

Inferred from electronic annotation. Source: Ensembl

ureteric bud morphogenesis

Inferred from expression pattern Ref.1. Source: UniProtKB

ventricular septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 20103596PubMed 20219091. Source: UniProtKB

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRas GTPase activator activity

Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB

frizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein kinase activator activity

Inferred from mutant phenotype PubMed 20103596PubMed 20219091. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay PubMed 19847889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 354330Protein Wnt-11
PRO_0000041465

Amino acid modifications

Lipidation801S-palmitoyl cysteine By similarity
Lipidation2151O-palmitoyl serine; by PORCN By similarity
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3041N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1211A → T in CAA74159. Ref.1
Sequence conflict1211A → T in CAA73223. Ref.1
Sequence conflict1561G → R in CAA74159. Ref.1
Sequence conflict1561G → R in CAA73223. Ref.1
Sequence conflict2711S → W in CAA74159. Ref.1
Sequence conflict2711S → W in CAA73223. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O96014 [UniParc].

Last modified May 10, 2002. Version 2.
Checksum: 0E29717C98541DBB

FASTA35439,179
        10         20         30         40         50         60 
MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG LVSAQVQLCR 

        70         80         90        100        110        120 
SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 

       130        140        150        160        170        180 
AISHAIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 

       190        200        210        220        230        240 
TGSQANKLMR LHNSEVGRQA LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR 

       250        260        270        280        290        300 
YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 

       310        320        330        340        350 
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung."
Lako M., Strachan T., Bullen P., Wilson D.I., Robson S.C., Lindsay S.
Gene 219:101-110(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Molecular cloning and characterization of human WNT11."
Kirikoshi H., Sekihara H., Katoh M.
Int. J. Mol. Med. 8:651-656(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13843 expand/collapse EMBL AC list , Y13844, Y13845, Y13846, Y13847 Genomic DNA. Translation: CAA74159.1.
Y12692 mRNA. Translation: CAA73223.1.
AB070218 mRNA. Translation: BAB72099.1.
AK313570 mRNA. Translation: BAG36343.1.
BC074790 mRNA. Translation: AAH74790.1.
BC074791 mRNA. Translation: AAH74791.1.
BC113386 mRNA. Translation: AAI13387.1.
BC113388 mRNA. Translation: AAI13389.1.
RefSeqNP_004617.2. NM_004626.2.
XP_005274288.1. XM_005274231.1.
UniGeneHs.108219.

3D structure databases

ProteinModelPortalO96014.
SMRO96014. Positions 60-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113318. 1 interaction.
IntActO96014. 1 interaction.
MINTMINT-7003207.
STRING9606.ENSP00000325526.

PTM databases

PhosphoSiteO96014.

Proteomic databases

PaxDbO96014.
PRIDEO96014.

Protocols and materials databases

DNASU7481.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322563; ENSP00000325526; ENSG00000085741.
GeneID7481.
KEGGhsa:7481.
UCSCuc001oxe.3. human.

Organism-specific databases

CTD7481.
GeneCardsGC11M075897.
HGNCHGNC:12776. WNT11.
HPAHPA050101.
MIM603699. gene.
neXtProtNX_O96014.
PharmGKBPA37378.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG273917.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidO96014.
KOK01384.
OMAMHTIVHA.
OrthoDBEOG7C8GJ8.
PhylomeDBO96014.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO96014.
CleanExHS_WNT11.
GenevestigatorO96014.

Family and domain databases

InterProIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiWNT11.
GenomeRNAi7481.
NextBio29304.
PROO96014.
SOURCESearch...

Entry information

Entry nameWNT11_HUMAN
AccessionPrimary (citable) accession number: O96014
Secondary accession number(s): B2R8Z6, Q14DE8, Q8WZ98
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM