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O96014

- WNT11_HUMAN

UniProt

O96014 - WNT11_HUMAN

Protein

Protein Wnt-11

Gene

WNT11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. protein kinase activator activity Source: UniProtKB
    3. Ras GTPase activator activity Source: UniProtKB
    4. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. adrenal gland development Source: UniProtKB
    2. artery morphogenesis Source: Ensembl
    3. bone mineralization Source: Ensembl
    4. canonical Wnt signaling pathway Source: Ensembl
    5. cell fate commitment Source: RefGenome
    6. cellular response to retinoic acid Source: UniProtKB
    7. cloacal septation Source: UniProtKB
    8. embryonic skeletal system development Source: UniProtKB
    9. lung-associated mesenchyme development Source: UniProtKB
    10. mesonephric duct development Source: UniProtKB
    11. negative regulation of apoptotic process Source: UniProtKB
    12. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    13. negative regulation of cartilage development Source: UniProtKB
    14. negative regulation of cell death Source: UniProtKB
    15. negative regulation of cell growth Source: UniProtKB
    16. negative regulation of cell migration Source: UniProtKB
    17. negative regulation of fibroblast growth factor production Source: Ensembl
    18. negative regulation of mesenchymal cell proliferation Source: Ensembl
    19. negative regulation of transcription, DNA-templated Source: UniProtKB
    20. neuroendocrine cell differentiation Source: UniProtKB
    21. neuron differentiation Source: UniProtKB
    22. non-canonical Wnt signaling pathway Source: Ensembl
    23. osteoblast differentiation Source: Ensembl
    24. outflow tract morphogenesis Source: Ensembl
    25. palate development Source: BHF-UCL
    26. positive regulation of apoptotic process Source: Ensembl
    27. positive regulation of cell migration Source: UniProtKB
    28. positive regulation of gene expression Source: UniProtKB
    29. positive regulation of protein kinase activity Source: GOC
    30. positive regulation of protein kinase C signaling Source: UniProtKB
    31. positive regulation of Ras GTPase activity Source: UniProtKB
    32. positive regulation of stress fiber assembly Source: UniProtKB
    33. positive regulation of transcription, DNA-templated Source: UniProtKB
    34. positive regulation of transforming growth factor beta2 production Source: Ensembl
    35. protein localization to cell surface Source: UniProtKB
    36. protein phosphorylation Source: UniProtKB
    37. response to nutrient levels Source: Ensembl
    38. tight junction assembly Source: Ensembl
    39. ureteric bud morphogenesis Source: UniProtKB
    40. ventricular septum morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_172581. PCP/CE pathway.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-11
    Gene namesi
    Name:WNT11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:12776. WNT11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: Reactome
    3. extracellular space Source: RefGenome
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37378.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 354330Protein Wnt-11PRO_0000041465Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi80 ↔ 91By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi130 ↔ 138By similarity
    Disulfide bondi140 ↔ 157By similarity
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi209 ↔ 223By similarity
    Disulfide bondi211 ↔ 218By similarity
    Lipidationi215 – 2151O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi299 ↔ 314By similarity
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi329 ↔ 344By similarity
    Disulfide bondi331 ↔ 341By similarity
    Disulfide bondi336 ↔ 337By similarity

    Post-translational modificationi

    Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO96014.
    PRIDEiO96014.

    PTM databases

    PhosphoSiteiO96014.

    Expressioni

    Tissue specificityi

    Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.1 Publication

    Gene expression databases

    BgeeiO96014.
    CleanExiHS_WNT11.
    GenevestigatoriO96014.

    Organism-specific databases

    HPAiHPA050101.

    Interactioni

    Protein-protein interaction databases

    BioGridi113318. 1 interaction.
    IntActiO96014. 1 interaction.
    MINTiMINT-7003207.
    STRINGi9606.ENSP00000325526.

    Structurei

    3D structure databases

    ProteinModelPortaliO96014.
    SMRiO96014. Positions 74-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG273917.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiO96014.
    KOiK01384.
    OMAiELIYLQS.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiO96014.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026536. Wnt-11.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF7. PTHR12027:SF7. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O96014-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG    50
    LVSAQVQLCR SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY 100
    LLDLERGTRE SAFVYALSAA AISHAIARAC TSGDLPGCSC GPVPGEPPGP 150
    GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA 200
    LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR 250
    PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 300
    KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER 350
    YVCK 354
    Length:354
    Mass (Da):39,179
    Last modified:May 10, 2002 - v2
    Checksum:i0E29717C98541DBB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211A → T in CAA74159. (PubMed:9757009)Curated
    Sequence conflicti121 – 1211A → T in CAA73223. (PubMed:9757009)Curated
    Sequence conflicti156 – 1561G → R in CAA74159. (PubMed:9757009)Curated
    Sequence conflicti156 – 1561G → R in CAA73223. (PubMed:9757009)Curated
    Sequence conflicti271 – 2711S → W in CAA74159. (PubMed:9757009)Curated
    Sequence conflicti271 – 2711S → W in CAA73223. (PubMed:9757009)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13843
    , Y13844, Y13845, Y13846, Y13847 Genomic DNA. Translation: CAA74159.1.
    Y12692 mRNA. Translation: CAA73223.1.
    AB070218 mRNA. Translation: BAB72099.1.
    AK313570 mRNA. Translation: BAG36343.1.
    BC074790 mRNA. Translation: AAH74790.1.
    BC074791 mRNA. Translation: AAH74791.1.
    BC113386 mRNA. Translation: AAI13387.1.
    BC113388 mRNA. Translation: AAI13389.1.
    CCDSiCCDS8242.1.
    RefSeqiNP_004617.2. NM_004626.2.
    XP_005274288.1. XM_005274231.1.
    UniGeneiHs.108219.

    Genome annotation databases

    EnsembliENST00000322563; ENSP00000325526; ENSG00000085741.
    GeneIDi7481.
    KEGGihsa:7481.
    UCSCiuc001oxe.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13843
    , Y13844 , Y13845 , Y13846 , Y13847 Genomic DNA. Translation: CAA74159.1 .
    Y12692 mRNA. Translation: CAA73223.1 .
    AB070218 mRNA. Translation: BAB72099.1 .
    AK313570 mRNA. Translation: BAG36343.1 .
    BC074790 mRNA. Translation: AAH74790.1 .
    BC074791 mRNA. Translation: AAH74791.1 .
    BC113386 mRNA. Translation: AAI13387.1 .
    BC113388 mRNA. Translation: AAI13389.1 .
    CCDSi CCDS8242.1.
    RefSeqi NP_004617.2. NM_004626.2.
    XP_005274288.1. XM_005274231.1.
    UniGenei Hs.108219.

    3D structure databases

    ProteinModelPortali O96014.
    SMRi O96014. Positions 74-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113318. 1 interaction.
    IntActi O96014. 1 interaction.
    MINTi MINT-7003207.
    STRINGi 9606.ENSP00000325526.

    PTM databases

    PhosphoSitei O96014.

    Proteomic databases

    PaxDbi O96014.
    PRIDEi O96014.

    Protocols and materials databases

    DNASUi 7481.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322563 ; ENSP00000325526 ; ENSG00000085741 .
    GeneIDi 7481.
    KEGGi hsa:7481.
    UCSCi uc001oxe.3. human.

    Organism-specific databases

    CTDi 7481.
    GeneCardsi GC11M075897.
    HGNCi HGNC:12776. WNT11.
    HPAi HPA050101.
    MIMi 603699. gene.
    neXtProti NX_O96014.
    PharmGKBi PA37378.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG273917.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi O96014.
    KOi K01384.
    OMAi ELIYLQS.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi O96014.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_172581. PCP/CE pathway.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GeneWikii WNT11.
    GenomeRNAii 7481.
    NextBioi 29304.
    PROi O96014.
    SOURCEi Search...

    Gene expression databases

    Bgeei O96014.
    CleanExi HS_WNT11.
    Genevestigatori O96014.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026536. Wnt-11.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF7. PTHR12027:SF7. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung."
      Lako M., Strachan T., Bullen P., Wilson D.I., Robson S.C., Lindsay S.
      Gene 219:101-110(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Molecular cloning and characterization of human WNT11."
      Kirikoshi H., Sekihara H., Katoh M.
      Int. J. Mol. Med. 8:651-656(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Fetal brain.

    Entry informationi

    Entry nameiWNT11_HUMAN
    AccessioniPrimary (citable) accession number: O96014
    Secondary accession number(s): B2R8Z6, Q14DE8, Q8WZ98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3