O96014 (WNT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-11

Gene names

Name:

WNT11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas. Ref.2
Post-translational modification	Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface By similarity.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adrenal gland development Inferred from expression pattern Ref.1. Source: UniProtKB anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome artery morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome bone mineralization Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB cloacal septation Inferred from expression pattern Ref.1. Source: UniProtKB embryonic skeletal system development Inferred from expression pattern Ref.1. Source: UniProtKB endoderm development Inferred from Biological aspect of Ancestor. Source: RefGenome lung-associated mesenchyme development Inferred from expression pattern Ref.1. Source: UniProtKB mesonephric duct development Inferred from expression pattern Ref.1. Source: UniProtKB negative regulation of apoptotic process Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB negative regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB negative regulation of cartilage development Non-traceable author statement Ref.1. Source: UniProtKB negative regulation of cell growth Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB negative regulation of cell migration Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB negative regulation of fibroblast growth factor production Inferred from electronic annotation. Source: Compara negative regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 20103596PubMed 20219091. Source: UniProtKB neuroendocrine cell differentiation Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB non-canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome outflow tract morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome palate development Inferred from mutant phenotype PubMed 18413325. Source: BHF-UCL positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from mutant phenotype PubMed 20219091. Source: UniProtKB positive regulation of protein kinase C signaling cascade Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB positive regulation of stress fiber assembly Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 19847889. Source: UniProtKB positive regulation of transforming growth factor beta2 production Inferred from Biological aspect of Ancestor. Source: RefGenome protein localization to cell surface Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB protein phosphorylation Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB tight junction assembly Inferred from Biological aspect of Ancestor. Source: RefGenome ureteric bud morphogenesis Inferred from expression pattern Ref.1. Source: UniProtKB ventricular septum morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from direct assay PubMed 20103596PubMed 20219091. Source: UniProtKB extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome Ras GTPase activator activity Inferred from mutant phenotype PubMed 20103596. Source: UniProtKB protein kinase activator activity Inferred from mutant phenotype PubMed 20103596PubMed 20219091. Source: UniProtKB transcription regulatory region DNA binding Inferred from direct assay PubMed 19847889. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 354	330	Protein Wnt-11		PRO_0000041465
Amino acid modifications
	Lipidation	80	1	S-palmitoyl cysteine By similarity
	Lipidation	215	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	160	1	N-linked (GlcNAc...) Potential
	Glycosylation	300	1	N-linked (GlcNAc...) Potential
	Glycosylation	304	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	121	1	A → T in CAA74159. Ref.1
	Sequence conflict	121	1	A → T in CAA73223. Ref.1
	Sequence conflict	156	1	G → R in CAA74159. Ref.1
	Sequence conflict	156	1	G → R in CAA73223. Ref.1
	Sequence conflict	271	1	S → W in CAA74159. Ref.1
	Sequence conflict	271	1	S → W in CAA73223. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O96014 [UniParc]. Last modified May 10, 2002. Version 2. Checksum: 0E29717C98541DBB	FASTA	354	39,179
	10 20 30 40 50 60 MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG LVSAQVQLCR 70 80 90 100 110 120 SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 130 140 150 160 170 180 AISHAIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 190 200 210 220 230 240 TGSQANKLMR LHNSEVGRQA LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR 250 260 270 280 290 300 YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 310 320 330 340 350 KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung." Lako M., Strachan T., Bullen P., Wilson D.I., Robson S.C., Lindsay S. Gene 219:101-110(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Molecular cloning and characterization of human WNT11." Kirikoshi H., Sekihara H., Katoh M. Int. J. Mol. Med. 8:651-656(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13843 , Y13844, Y13845, Y13846, Y13847 Genomic DNA. Translation: CAA74159.1. Y12692 mRNA. Translation: CAA73223.1. AB070218 mRNA. Translation: BAB72099.1. AK313570 mRNA. Translation: BAG36343.1. BC074790 mRNA. Translation: AAH74790.1. BC074791 mRNA. Translation: AAH74791.1. BC113386 mRNA. Translation: AAI13387.1. BC113388 mRNA. Translation: AAI13389.1.
IPI	IPI00014069.
RefSeq	NP_004617.2. NM_004626.2.
UniGene	Hs.108219.
3D structure databases
ProteinModelPortal	O96014.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000325526.
PTM databases
PhosphoSite	O96014.
Proteomic databases
PaxDb	O96014.
PRIDE	O96014.
Protocols and materials databases
DNASU	7481.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322563; ENSP00000325526; ENSG00000085741.
GeneID	7481.
KEGG	hsa:7481.
UCSC	uc001oxe.3. human.
Organism-specific databases
CTD	7481.
GeneCards	GC11M075897.
HGNC	HGNC:12776. WNT11.
HPA	HPA050101.
MIM	603699. gene.
neXtProt	NX_O96014.
PharmGKB	PA37378.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG273917.
HOGENOM	HOG000039529.
HOVERGEN	HBG001595.
InParanoid	O96014.
KO	K01384.
OMA	ELIYLQS.
OrthoDB	EOG4FR0RT.
PhylomeDB	O96014.
Enzyme and pathway databases
Pathway_Interaction_DB	wnt_calcium_pathway. Noncanonical Wnt signaling pathway. wnt_signaling_pathway. Wnt signaling.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O96014.
Bgee	O96014.
CleanEx	HS_WNT11.
Genevestigator	O96014.
GermOnline	ENSG00000085741. Homo sapiens.
Family and domain databases
InterPro	IPR005817. Wnt. IPR026536. Wnt-11. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF7. PTHR12027:SF7. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7481.
NextBio	29304.
SOURCE	Search...

Entry information

Entry name

WNT11_HUMAN

Accession

Primary (citable) accession number: O96014
Secondary accession number(s): B2R8Z6, Q14DE8, Q8WZ98

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 10, 2002
Last modified:	April 3, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.