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O96014

- WNT11_HUMAN

UniProt

O96014 - WNT11_HUMAN

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Protein

Protein Wnt-11

Gene
WNT11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. protein kinase activator activity Source: UniProtKB
  3. Ras GTPase activator activity Source: UniProtKB
  4. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. adrenal gland development Source: UniProtKB
  2. artery morphogenesis Source: Ensembl
  3. bone mineralization Source: Ensembl
  4. canonical Wnt signaling pathway Source: Ensembl
  5. cell fate commitment Source: RefGenome
  6. cellular response to retinoic acid Source: UniProtKB
  7. cloacal septation Source: UniProtKB
  8. embryonic skeletal system development Source: UniProtKB
  9. lung-associated mesenchyme development Source: UniProtKB
  10. mesonephric duct development Source: UniProtKB
  11. negative regulation of apoptotic process Source: UniProtKB
  12. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  13. negative regulation of cartilage development Source: UniProtKB
  14. negative regulation of cell death Source: UniProtKB
  15. negative regulation of cell growth Source: UniProtKB
  16. negative regulation of cell migration Source: UniProtKB
  17. negative regulation of fibroblast growth factor production Source: Ensembl
  18. negative regulation of mesenchymal cell proliferation Source: Ensembl
  19. negative regulation of transcription, DNA-templated Source: UniProtKB
  20. neuroendocrine cell differentiation Source: UniProtKB
  21. neuron differentiation Source: UniProtKB
  22. non-canonical Wnt signaling pathway Source: Ensembl
  23. osteoblast differentiation Source: Ensembl
  24. outflow tract morphogenesis Source: Ensembl
  25. palate development Source: BHF-UCL
  26. positive regulation of apoptotic process Source: Ensembl
  27. positive regulation of cell migration Source: UniProtKB
  28. positive regulation of gene expression Source: UniProtKB
  29. positive regulation of protein kinase activity Source: GOC
  30. positive regulation of protein kinase C signaling Source: UniProtKB
  31. positive regulation of Ras GTPase activity Source: UniProtKB
  32. positive regulation of stress fiber assembly Source: UniProtKB
  33. positive regulation of transcription, DNA-templated Source: UniProtKB
  34. positive regulation of transforming growth factor beta2 production Source: Ensembl
  35. protein localization to cell surface Source: UniProtKB
  36. protein phosphorylation Source: UniProtKB
  37. response to nutrient levels Source: Ensembl
  38. tight junction assembly Source: Ensembl
  39. ureteric bud morphogenesis Source: UniProtKB
  40. ventricular septum morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_172581. PCP/CE pathway.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:WNT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:12776. WNT11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: Reactome
  3. extracellular space Source: RefGenome
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 354330Protein Wnt-11PRO_0000041465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi80 ↔ 91 By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi130 ↔ 138 By similarity
Disulfide bondi140 ↔ 157 By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi209 ↔ 223 By similarity
Disulfide bondi211 ↔ 218 By similarity
Lipidationi215 – 2151O-palmitoyl serine; by PORCN By similarity
Disulfide bondi299 ↔ 314 By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi329 ↔ 344 By similarity
Disulfide bondi331 ↔ 341 By similarity
Disulfide bondi336 ↔ 337 By similarity

Post-translational modificationi

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO96014.
PRIDEiO96014.

PTM databases

PhosphoSiteiO96014.

Expressioni

Tissue specificityi

Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.1 Publication

Gene expression databases

BgeeiO96014.
CleanExiHS_WNT11.
GenevestigatoriO96014.

Organism-specific databases

HPAiHPA050101.

Interactioni

Protein-protein interaction databases

BioGridi113318. 1 interaction.
IntActiO96014. 1 interaction.
MINTiMINT-7003207.
STRINGi9606.ENSP00000325526.

Structurei

3D structure databases

ProteinModelPortaliO96014.
SMRiO96014. Positions 74-283.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO96014.
KOiK01384.
OMAiELIYLQS.
OrthoDBiEOG7C8GJ8.
PhylomeDBiO96014.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96014-1 [UniParc]FASTAAdd to Basket

« Hide

MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG    50
LVSAQVQLCR SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY 100
LLDLERGTRE SAFVYALSAA AISHAIARAC TSGDLPGCSC GPVPGEPPGP 150
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA 200
LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR 250
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 300
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER 350
YVCK 354
Length:354
Mass (Da):39,179
Last modified:May 10, 2002 - v2
Checksum:i0E29717C98541DBB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211A → T in CAA74159. 1 Publication
Sequence conflicti121 – 1211A → T in CAA73223. 1 Publication
Sequence conflicti156 – 1561G → R in CAA74159. 1 Publication
Sequence conflicti156 – 1561G → R in CAA73223. 1 Publication
Sequence conflicti271 – 2711S → W in CAA74159. 1 Publication
Sequence conflicti271 – 2711S → W in CAA73223. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13843
, Y13844, Y13845, Y13846, Y13847 Genomic DNA. Translation: CAA74159.1.
Y12692 mRNA. Translation: CAA73223.1.
AB070218 mRNA. Translation: BAB72099.1.
AK313570 mRNA. Translation: BAG36343.1.
BC074790 mRNA. Translation: AAH74790.1.
BC074791 mRNA. Translation: AAH74791.1.
BC113386 mRNA. Translation: AAI13387.1.
BC113388 mRNA. Translation: AAI13389.1.
CCDSiCCDS8242.1.
RefSeqiNP_004617.2. NM_004626.2.
XP_005274288.1. XM_005274231.1.
UniGeneiHs.108219.

Genome annotation databases

EnsembliENST00000322563; ENSP00000325526; ENSG00000085741.
GeneIDi7481.
KEGGihsa:7481.
UCSCiuc001oxe.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13843
, Y13844 , Y13845 , Y13846 , Y13847 Genomic DNA. Translation: CAA74159.1 .
Y12692 mRNA. Translation: CAA73223.1 .
AB070218 mRNA. Translation: BAB72099.1 .
AK313570 mRNA. Translation: BAG36343.1 .
BC074790 mRNA. Translation: AAH74790.1 .
BC074791 mRNA. Translation: AAH74791.1 .
BC113386 mRNA. Translation: AAI13387.1 .
BC113388 mRNA. Translation: AAI13389.1 .
CCDSi CCDS8242.1.
RefSeqi NP_004617.2. NM_004626.2.
XP_005274288.1. XM_005274231.1.
UniGenei Hs.108219.

3D structure databases

ProteinModelPortali O96014.
SMRi O96014. Positions 74-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113318. 1 interaction.
IntActi O96014. 1 interaction.
MINTi MINT-7003207.
STRINGi 9606.ENSP00000325526.

PTM databases

PhosphoSitei O96014.

Proteomic databases

PaxDbi O96014.
PRIDEi O96014.

Protocols and materials databases

DNASUi 7481.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322563 ; ENSP00000325526 ; ENSG00000085741 .
GeneIDi 7481.
KEGGi hsa:7481.
UCSCi uc001oxe.3. human.

Organism-specific databases

CTDi 7481.
GeneCardsi GC11M075897.
HGNCi HGNC:12776. WNT11.
HPAi HPA050101.
MIMi 603699. gene.
neXtProti NX_O96014.
PharmGKBi PA37378.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG273917.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi O96014.
KOi K01384.
OMAi ELIYLQS.
OrthoDBi EOG7C8GJ8.
PhylomeDBi O96014.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_172581. PCP/CE pathway.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).

Miscellaneous databases

GeneWikii WNT11.
GenomeRNAii 7481.
NextBioi 29304.
PROi O96014.
SOURCEi Search...

Gene expression databases

Bgeei O96014.
CleanExi HS_WNT11.
Genevestigatori O96014.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung."
    Lako M., Strachan T., Bullen P., Wilson D.I., Robson S.C., Lindsay S.
    Gene 219:101-110(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Molecular cloning and characterization of human WNT11."
    Kirikoshi H., Sekihara H., Katoh M.
    Int. J. Mol. Med. 8:651-656(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Fetal brain.

Entry informationi

Entry nameiWNT11_HUMAN
AccessioniPrimary (citable) accession number: O96014
Secondary accession number(s): B2R8Z6, Q14DE8, Q8WZ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi