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Protein

Protein Wnt-11

Gene

WNT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • GTPase activator activity Source: UniProtKB
  • protein kinase activator activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • adrenal gland development Source: UniProtKB
  • artery morphogenesis Source: Ensembl
  • bicellular tight junction assembly Source: Ensembl
  • bone mineralization Source: Ensembl
  • canonical Wnt signaling pathway Source: Ensembl
  • cell fate commitment Source: GO_Central
  • cellular response to retinoic acid Source: UniProtKB
  • cloacal septation Source: UniProtKB
  • embryonic skeletal system development Source: UniProtKB
  • lung-associated mesenchyme development Source: UniProtKB
  • mesonephric duct development Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of cartilage development Source: UniProtKB
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of fibroblast growth factor production Source: Ensembl
  • negative regulation of mesenchymal cell proliferation Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neuroendocrine cell differentiation Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • non-canonical Wnt signaling pathway Source: Ensembl
  • osteoblast differentiation Source: Ensembl
  • outflow tract morphogenesis Source: Ensembl
  • palate development Source: BHF-UCL
  • positive regulation of apoptotic process Source: Ensembl
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of protein kinase activity Source: GOC
  • positive regulation of protein kinase C signaling Source: UniProtKB
  • positive regulation of stress fiber assembly Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transforming growth factor beta2 production Source: Ensembl
  • protein localization to cell surface Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • response to nutrient levels Source: Ensembl
  • ureteric bud morphogenesis Source: UniProtKB
  • ventricular septum morphogenesis Source: Ensembl
  • Wnt signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_263982. Ca2+ pathway.
REACT_264199. PCP/CE pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:WNT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12776. WNT11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37378.

Polymorphism and mutation databases

BioMutaiWNT11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 354330Protein Wnt-11PRO_0000041465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi80 ↔ 91By similarity
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 138By similarity
Disulfide bondi140 ↔ 157By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi209 ↔ 223By similarity
Disulfide bondi211 ↔ 218By similarity
Lipidationi215 – 2151O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi299 ↔ 314By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi329 ↔ 344By similarity
Disulfide bondi331 ↔ 341By similarity
Disulfide bondi336 ↔ 337By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiO96014.
PRIDEiO96014.

PTM databases

PhosphoSiteiO96014.

Expressioni

Tissue specificityi

Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.1 Publication

Gene expression databases

BgeeiO96014.
CleanExiHS_WNT11.
ExpressionAtlasiO96014. baseline and differential.
GenevisibleiO96014. HS.

Organism-specific databases

HPAiHPA050101.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-8058160,EBI-10172290
KRTAP10-9P604113EBI-8058160,EBI-10172052
MDFIQ997503EBI-8058160,EBI-724076

Protein-protein interaction databases

BioGridi113318. 3 interactions.
IntActiO96014. 4 interactions.
MINTiMINT-7003207.
STRINGi9606.ENSP00000325526.

Structurei

3D structure databases

ProteinModelPortaliO96014.
SMRiO96014. Positions 74-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO96014.
KOiK01384.
OMAiELIYLQS.
OrthoDBiEOG7C8GJ8.
PhylomeDBiO96014.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG
60 70 80 90 100
LVSAQVQLCR SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY
110 120 130 140 150
LLDLERGTRE SAFVYALSAA AISHAIARAC TSGDLPGCSC GPVPGEPPGP
160 170 180 190 200
GNRWGGCADN LSYGLLMGAK FSDAPMKVKK TGSQANKLMR LHNSEVGRQA
210 220 230 240 250
LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR YLSATKVVHR
260 270 280 290 300
PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN
310 320 330 340 350
KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER

YVCK
Length:354
Mass (Da):39,179
Last modified:May 10, 2002 - v2
Checksum:i0E29717C98541DBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211A → T in CAA74159 (PubMed:9757009).Curated
Sequence conflicti121 – 1211A → T in CAA73223 (PubMed:9757009).Curated
Sequence conflicti156 – 1561G → R in CAA74159 (PubMed:9757009).Curated
Sequence conflicti156 – 1561G → R in CAA73223 (PubMed:9757009).Curated
Sequence conflicti271 – 2711S → W in CAA74159 (PubMed:9757009).Curated
Sequence conflicti271 – 2711S → W in CAA73223 (PubMed:9757009).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13843
, Y13844, Y13845, Y13846, Y13847 Genomic DNA. Translation: CAA74159.1.
Y12692 mRNA. Translation: CAA73223.1.
AB070218 mRNA. Translation: BAB72099.1.
AK313570 mRNA. Translation: BAG36343.1.
BC074790 mRNA. Translation: AAH74790.1.
BC074791 mRNA. Translation: AAH74791.1.
BC113386 mRNA. Translation: AAI13387.1.
BC113388 mRNA. Translation: AAI13389.1.
CCDSiCCDS8242.1.
RefSeqiNP_004617.2. NM_004626.2.
XP_005274288.1. XM_005274231.1.
UniGeneiHs.108219.

Genome annotation databases

EnsembliENST00000322563; ENSP00000325526; ENSG00000085741.
GeneIDi7481.
KEGGihsa:7481.
UCSCiuc001oxe.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13843
, Y13844, Y13845, Y13846, Y13847 Genomic DNA. Translation: CAA74159.1.
Y12692 mRNA. Translation: CAA73223.1.
AB070218 mRNA. Translation: BAB72099.1.
AK313570 mRNA. Translation: BAG36343.1.
BC074790 mRNA. Translation: AAH74790.1.
BC074791 mRNA. Translation: AAH74791.1.
BC113386 mRNA. Translation: AAI13387.1.
BC113388 mRNA. Translation: AAI13389.1.
CCDSiCCDS8242.1.
RefSeqiNP_004617.2. NM_004626.2.
XP_005274288.1. XM_005274231.1.
UniGeneiHs.108219.

3D structure databases

ProteinModelPortaliO96014.
SMRiO96014. Positions 74-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113318. 3 interactions.
IntActiO96014. 4 interactions.
MINTiMINT-7003207.
STRINGi9606.ENSP00000325526.

PTM databases

PhosphoSiteiO96014.

Polymorphism and mutation databases

BioMutaiWNT11.

Proteomic databases

PaxDbiO96014.
PRIDEiO96014.

Protocols and materials databases

DNASUi7481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322563; ENSP00000325526; ENSG00000085741.
GeneIDi7481.
KEGGihsa:7481.
UCSCiuc001oxe.3. human.

Organism-specific databases

CTDi7481.
GeneCardsiGC11M075897.
HGNCiHGNC:12776. WNT11.
HPAiHPA050101.
MIMi603699. gene.
neXtProtiNX_O96014.
PharmGKBiPA37378.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG273917.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO96014.
KOiK01384.
OMAiELIYLQS.
OrthoDBiEOG7C8GJ8.
PhylomeDBiO96014.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_263982. Ca2+ pathway.
REACT_264199. PCP/CE pathway.

Miscellaneous databases

GeneWikiiWNT11.
GenomeRNAii7481.
NextBioi29304.
PROiO96014.
SOURCEiSearch...

Gene expression databases

BgeeiO96014.
CleanExiHS_WNT11.
ExpressionAtlasiO96014. baseline and differential.
GenevisibleiO96014. HS.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026536. Wnt-11.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF7. PTHR12027:SF7. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung."
    Lako M., Strachan T., Bullen P., Wilson D.I., Robson S.C., Lindsay S.
    Gene 219:101-110(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Molecular cloning and characterization of human WNT11."
    Kirikoshi H., Sekihara H., Katoh M.
    Int. J. Mol. Med. 8:651-656(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Fetal brain.

Entry informationi

Entry nameiWNT11_HUMAN
AccessioniPrimary (citable) accession number: O96014
Secondary accession number(s): B2R8Z6, Q14DE8, Q8WZ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: July 22, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.